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【31st.May】Nanomaterials and Nanosystems: From Design to Application

2018-05-31


TOPIC:Nanomaterials and Nanosystems: From Design to Application

SPEAKER:Prof. Pik Kwan (Peggy) Lo,Department of Biology and Chemistry, City University of Hong Kong
TIME:May 31 (Thursday)10:00 am 
LOCATION:Room 410, Chemistry Building B (化学B楼410会议室)
INVITER:麦亦勇 特别研究员

Nanomaterials and Nanosystems: From Design to Application


Pik Kwan Lo

Department of Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong SAR China; 

Shenzhen Key Laboratory of Biochip Research, City University of Hong Kong, Shenzhen 518057, PR China

peggylo@cityu.edu.hk


Abstract:
Nanotechnology allows for the unique design and functionalization of materials and devices at the nanometer scale for a variety of applications in physics, biology, nanoelectronics, and materials science. 



We have devoted to the development of stimuli-responsive 2D/3D nanomaterials, which demonstrate their ability to respond in an autonomous manner upon being triggered by an external stimuli for targeted drug delivery, biosensing, diagnostics, and therapy, and to the use of multifunctional nanodiamonds as a platform for bioimaging, gene delivery and disease therapy. 


Our research also intends to develop DNA-mimetic polymers with specific nucleic acid sequences through solid-phase synthesis approach. Their potentials as novel antisense or antigene drug for gene therapy and as attractive building blocks in the area of nanoscience are also investigated accordingly. 
References
1. L. S. Liu, H. M. Leung, D. Y. Tam, T. W. Lo, S. W. Wong, P. K. Lo. “α-L-Threose Nucleic Acids as Biocompatible Antisense Oligonucleotides for Suppressing Gene Expression in Living Cells” ACS Applied Materials & Interfaces 2018, 10, 9736-9743.
2. Z. Dai, P. K. Lo. “Photo-switchable patterning of gold nanoparticles along 3D DNA nanotubes” Nanoscale 2018, 10, 5431-5435.
3. D. Y. Tam, H. M. Leung, M. S. Chan, P. K. Lo. “G-Quadruplex-Mediated Molecular Switching of Self-Assembled 3D DNA Nanocages” ChemNanoMat 2017, 3, 750-754. 
4. M. S. Chan, H. M. Leung, L. S. Liu, P. K. Lo. “Cancer-Cell-Specific Mitochondria-Targeted Drug Delivery by Dual-Ligand-Functionalized Nanodiamonds Circumvents Drug Resistance” ACS Applied Materials & Interfaces 2017, 9, 11780-11789. 
5. Z. Dai, H. M. Leung, P. K. Lo. “Stimuli-Responsive Self-Assembled DNA Nanomaterials for Biomedical Applications” Small 2017, 13, 1602881. 
6. Z. Dai, Q. Gao, M. C. Cheung, H. M. Leung, T. C. K. Lau, H. F. Sleiman, K. W. C. Lai, P. K. Lo. “A Highly Versatile Platform Based on Geometrically Well-Defined 3D DNA Nanostructures for Selective Recognition and Positioning of Multiplex Targets” Nanoscale 2016, 8, 18291-18295. 
7. M. S. Chan, D. Y. Tam, Z. Dai, L. S. Liu, J. W. Ho, M. L. Chan, D. Xu, M. S. Wong, C. Tin, P. K. Lo. “Mitochondrial Delivery of Therapeutic Agents By Amphiphilic DNA Nanocarriers” Small 2016, 12, 770-781. 
8. D. Y. Tam, Z. Dai, M. S. Chan, L. S. Liu, M. C. Cheung, F. Bolze, C. Tin, P. K. Lo. “A Reversible DNA Logic Gate Platform Operated by One- and Two-Photon Excitations” Angew. Chem. Int. Ed. 2016, 55, 164-168. 
9. Z. Dai, D. Y. Tam, H. Xu, M. S. Chan, L. S. Liu, F, Bolze, X. H. Sun, P. K. Lo. “Conformational Change of Self-Assembled DNA Nanotubes Induced by Two-Photon Excitation” Small 2015, 11, 4090-4096. 
10. M. S. Chan, P. K. Lo. “Nanoneedle-Assisted Delivery of Site-Selective Peptide-Functionalized DNA Nanocages for Mitochondria and Nucleus Targeting” Small 2014, 10, 1255-1260. 


 Biography




Prof. Dr. Pik Kwan Peggy LO羅璧君博士
Profile Weblink: http://www.cityu.edu.hk/chem/profile/drpkl.html


Dr. Peggy Lo obtained her B.Sc in 2004 and M.Phil. in 2006 from Hong Kong Baptist University. In 2010, she received her Ph.D. from McGill University in Canada under the supervision of Prof. Hanadi. F Sleiman. She then moved to the United States for her postdoctoral research at Harvard University with Professor Hongkun Park (A. Editor of Nano Letters) from 2010 to 2012. She has been an Assistant Professor at City University of Hong Kong since 2012 and will get promoted to Associate Professor with substantiation in July 2018. 


Dr Lo has published over 60 peer-reviewed research articles in the leading international journals in the past 12 years including Nature, Nature Nanotechnology, Nature Chemistry, JACS, Angew. Chem. Int. Ed., Small, Nanoscale, ACS Applied Materials & Interfaces, Chem. Commun., Adv. Healthcare Materials, etc. 


In 2016, she was selected to receive The President’s Awards which recognize her exemplary contributions to research and professional education that have helped CityU to achieve local and global distinction. She has served as one of the editorial board members in Scientific Reports in Chemical Biology division since 2016. 


Her research area is highly interdisciplinary and lies at the interface between chemistry, biology, nanotechnology and materials science. Her research interest lies in developing multifunctional nano-sized materials and applying them for biomedical and technological applications. 






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