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王 平

1,基本信息:
姓名: 王平
职称:特别研究员
电话:021-54743264
邮箱:wangp1[at]sjtu.edu.cn 

主页:scce.sjtu.edu.cn
通讯地址:上海市东川路800号 化学B楼228

2. 教育经历
1996-2000:  南京大学化学系,学士
2000-2005:  中国科学院上海有机化学研究所,博士,导师:俞飚 研究员

3. 工作经历
2005-2008:  美国伯纳姆医学研究所,博士后,导师: Peter H.Seegerber 教授
2008-2013:  纪念斯隆凯特琳癌症中心,博士后、资深研究科学家,导师: Samuel J.Danishefsky 教授
2013-2016.2:  波士顿WARP DRIVE BIO 生物技术公司,研究科学家
2016.3- :  上海交通大学化学化工学院,特别研究员

4. 研究方向
1)化学合成具有重要生理活性的糖蛋白、糖肽
2)糖类分子合成及其方法学研究
3)多肽合成方法学研究
5. 荣誉及奖励
中组部第十二批“千人计划”青年人才项目
6. 代表性论文
1. Ping Wang, Suwei Dong, Jaehung Shieh, Ronald C. Hendrickson, Malcolm A. Moore, Samuel J. Danishefsky*. Erythropoietin Derived by Chemical Synthesis. Science. 2013, 342, 1357-1360.
2. Rebecca M. Wilson, Suwei Dong, Ping Wang and Samuel J. Danishefsky*. The Winding Pathway to Erythropoietin: Success At Last, Angew. Chem. Int. Ed. 2013, 52.
3. Xiaoyu Yang, Ping Wang, Biao Yu*. Tacking the challenges in the Total Synthesis of Landomycin A. The Chemical Record. 2013, 13, 70-84.
4. Ping Wang, Suwei Dong, Karthik Iyer, John A. Brailsford, Steve D. Townsend, Qiang Zhang, Ronald C. Hendrickson, Jaehung Shieh, Malcolm A. Moore, Samuel J. Danishefsky*. At Last: Erythropoietin as a Single Glycoform. Angew. Chem. Int. Ed. 2012, 51, 11576–11584. (Cover of the Journal, Highlighted by Science, Nature, Angew. Chem. Int. Ed., Chemistry World, ChemistryViews, C&EN NEWS)
5. Ping Wang, Baptiste Aussedat, Yusuf Vohra and Samuel J. Danishefsky*. An Advance in the Chemical Synthesis of Homogeneous N-Linked Glycopolypeptides by Convergent Aspartylation. Angew. Chem. Int. Ed. 2012, 51, 11571–11575.
6. Rebecca M. Wilson, Jennifer L. Stockdill, Paul A. Vadola, Xiangyang Wu, Xuechen Li, Peter Park, Ping Wang and Samuel J. Danishefsky*. A Journey into History: Exploration of the Fascinating World of Isonitriles. Angew. Chem. Int. Ed. 2012, 51, 2–17.
7. Toshiaki K. Shibata, Fumiko Matsumura, Ping Wang, ShinYi Yu, Kai-Hooi Khoo, Kazuko Kitayama1, Tomoya O. Akama1, Kazuhiro Sugihara, Kyoko Kojima-Aikawa, Peter H. Seeberger, Minoru Fukuda, Atsushi Suzuki, Daisuke Aoki, and Michiko N. Fukuda*.  Identification of mono- and di-sulfated N-acetyl-lactosaminyl oligosaccharide structures as epitopes specifically recognized by humanized monoclonal antibody HMOCC-1 raised against ovarian cancer. J. Biol. Chem. 2012, 287, 6592-6602.
8. Ping Wang, Xuechen Li, Jianglong Zhu, Jin Chen, Yu Yuan, Xiangyang Wu,  Samuel J. Danishefsky*. Encouraging Progress in the Ѡ-Aspartylation of Complex Oligosaccharides as a General Route to β-N-Linked Glycopolypeptides. J. Am. Chem. Soc. 2011. 133, 1597-1602.
9. Ping Wang and Samuel J. Danishefsky*. A Promising General Solution to the Problem of Ligating Peptides and Glycopeptides. J. Am. Chem. Soc. 2010. 132, 17045-17051.
10. Xiangyang Wu, Jennifer L. Stockdill, Ping Wang and Samuel J. Danishefsky*. Total Synthesis of Cyclosporine: Access to N-Methylated Peptides via Isonitrile Coupling Reactions. J. Am. Chem. Soc. 2010. 132, 4098-4100. (Highlighted by C&EN NEWS)
11. Jin Chen, Ping Wang, Jianglong Zhu, Qian Wan and Samuel, J. Danishefsky*. A Program for Ligation at Threonine Sites: Application to the Controlled Total Synthesis of Glycopeptides. Tetrahedron, 2010, 66, 2277-2283. (Cover of the Journal)
12. Ping Wang, Jianglong Zhu, Yu Yuan and Samuel, J. Danishefsky*. Total Synthesis of the 2, 6-Sialylated Immunoglobulin G Glycopeptide Fragment in Homogeneous Form. J. Am. Chem. Soc. 2009, 131, 16669-16671.
13. Heeseob Lee, Ping Wang, Motohiro Kobayashi, Jun Nakayama, Peter H. Seeberger* and Minoru Fukuda*. Cholesterol -glucosyltransferase unique to Helicobacter pylori sequentially acts on donor and acceptor substrates:  Implication for the mode of actions by therapeutic inhibitors. Glycobiology. 2008, Jul; 18(7):549-58. Epub 2008 May 5.
14. Ping Wang, Heeseob Lee, Minoru Fukuda and Peter H. Seeberger*. One-pot synthesis of a pentasaccharide with antibiotic activity against Helicobacter pylori. Chem. Commun., 2007, 1963-1965.
15. Heeseob Lee, Motohiro Kobayashi, Ping Wang, Jun Nakayama, Peter H. Seeberger and Minoru Fukuda*. Expression cloning of cholesterol alpha -glucosyltransferase, a unique enzyme that can be inhibited by natural antibiotic gastric mucin O-glycans, from Helicobacter pylori. Biochem. Biophys. Res. Commun. 2006 Nov 3; 349(4): 1235-41. Epub 2006 Sep 1.
16. Ping Wang, Zhaojun Zhang and Biao Yu*. Total synthesis of CRM646-A, B. J .Org. Chem. 2005, 70(22), 8884-8889.
17. Biao Yu* and Ping Wang. Efficient synthesis of the Hexasaccharide Fragment of Landomycin A: Using Phenyl 2,3-O-Thionocarbonyl-1-thioglycosides as 2-Deoxy-β-glycosides Precursors. Org. Lett. 2002, 4, 1919-1922.

专利
1. Jeffrey V. Ravetch, Andrew Pincetic, Ping Wang, Samuel J. Danishefsky, Human DC-SIGN binding peptides derived from IgG1 Fc fragment. PCT Int. Appl. 2013, WO 2013095973 A1 20130627.
2. Samuel J. Danishefsky, Ping Wang, Suwei Dong, Malcolm A. Moore , Jaehung Shieh,  John A. Brailsford,. Homogenous and fully glycosylated human erythropoietin. PCT Int. Appl. (2013), WO 2013166053 A2 20131107.
7. 其他
    欢迎对有机合成,糖化学、多肽合成以及相关化学生物学感兴趣的同学报考本组硕士、博士研究生和从事博士后研究。

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