主题：Total Synthesis of Indole Alkaloids Enabled by Asymmetric Pictet-Spengler Reaction of Ketones

报告人：祝介平

时间：2023年9月7日（周四）15：30—17：00

地点：霞光楼200报告厅

邀请人：张万斌 教授

个人简介

Received BSc degree from Hangzhou Normal University and MSc degree from Lanzhou University (P. R. China) under the guidance of Professor Li Yulin. He got his Ph.D.from University Paris XI, France under the supervision of Professor H.-P. Husson and Pr. J. C.Quirion. After 18 months post-doctoral stay with Professor Sir D. H. R. Barton at Texas A &  M University in USA, he joined the “Institut de Chimie des Substances Naturelles”, CNRS, France as Chargé de Recherche and was promoted to Director of Research 2nd class in 2000 and then 1st class in 2006. He moved to Ecole Polytechnique Fédérale de Lausanne (Swiss Federal Institute of Technology Lausanne), Switzerland in September 2010 as professor of Chemistry. His group is involved in the development of synthetic methodology, catalytic enantioselective transformations and total synthesis of complex natural products.

报告摘要

The asymmetric Pictect-Spengler reaction (PSR) between tryptamine and aldehydes is now well-developed. Conversely, catalytic enantioselective PSR of ketone is essentially unexploited. In this presentation, we will present our work on the catalytic enantioselective PSR of tryptamine with 1,2-diones, a-ketoesters and a-ketoamide for the synthesis of enantioenriched 1,1-disubstituted tetrahydro-bcarboline (THBC) and their application in the total synthesis of monoterpene indole alkaloids.