主 题 : The Journey with 1,2,3-Triazole Ligands: Rational Design and Serendipity
报告人: 史晓东 教授
时 间 : 2023年10月11日(周三)16: 00-17: 30
地 点 : 霞光楼200号报告厅
邀请人:张万斌 教授

摘要

The research in Shi group focused on new synthetic methodology developed based on the mechanistic insight. One particular area is the application of functional 1,2,3-triazole (TA) as ligand in tuning transition metal reactivity for novel catalyst design and new transformations. These efforts have led to critical mechanistic insight on how 1,2,3-triazole regulates metal reactivity, offering unique reactivity for challenging chemical and material problems. Some recent results include triazole gold catalysis (TA-Au), triazole ruthenium metathesis catalyst library (TA-Ru), triazole as directing group in C-H activation (TA- Pd), new triazole-based metal complexes (Fe, Mn, Ni, Cu) etc.

The triazole gold catalysis led to the discovery of thermal stable gold catalysts and Lewis acid assisted TA-Au activation. More recently, the gold chemistry was further extended into redox catalysis and application of vinyl gold intermediates as nucleophiles using synergistic gold/iron dual catalyst to prevent out rapid protodeauration. The TA-Ru carbene complexes were proved as novel class of metathesis catalysts that tolerate higher temperature without decomposition, allowing C=C bond forming process as equilibrium for dynamic covalent chemistry (DCvC). These new catalytic systems have been applied into practical synthesis of important molecules toward biomedicinal and material applications.

简介

Education:
06/2002 - 04/2005 Postdoc, Dept. of Chemistry, Univ. of California, Berkeley Mentors: Dr. Paul Bartlett, Dr. Dean Toste
08/1998 - 05/2002 Ph.D. Dept. of Chemistry, Univ. of Maryland, College Park Mentor: Dr. Jeffery T. Davis
09/1994 – 07/1997 MS, Dept. of Chemistry, Nankai University, China
09/1990 – 07/1994 BS, Dept. of Chemistry, Nankai University, China

Professional Experience:
08/2023 – present Professor, Department of Chemistry and Biochemistry, Univ. of Maryland College Park
05/2015 – 08/2023 Professor and Associate Chair, Department of Chemistry, University of South Florida
08/2005 – 08/2015 Assistant, Associate and Full Professor, Department of Chemistry,  West Virginia University
04/2005 - 08/2005 Platform Research Scientist, General Electric Advanced Material