题目：Molecular Gymnastics with Alkynes, Allenes and Light: Towards Atom Efficient Molecular Transformations
主讲人：Prof. Bernhard Breit, Freiburg University, Germany
简介：Bernhard Breit studied chemistry at the University of Kaiserslautern, Germany where he obtained his doctorate in 1993 with Professor Regitz. After postdoctoral training with Professor Trost at Stanford University, he worked in Marburg, Germany, with Professor R. W. Hoffmann to obtain his habilitation in 1998. In 1999 he was appointed as an Associate Professor at the University of Heidelberg, Germany. Since 2001 he has been a Full Professor of Organic Chemistry (Chair) at the Albert-Ludwigs-Universität Freiburg i. Brsg.
His research interests focus on the exploration and development of catalytic methods for organic synthesis, and its application in target oriented synthesis. He is author of more than 200 publications
摘要：Transformation of simple and readily accessible starting materials to branched allylic derivatives is an important topic in organic synthesis because of the versatility of the allylic moiety for further elaboration and the stereogenic center for asymmetric synthesis. In the last decades, significant progress toward this goal has been achieved, in particular with allylic substitution1 and allylic C-H oxidation chemistry. However, these methods require pre-installation of a leaving group or stoichiometric amounts of an oxidant, respectively.
As an alternative to these methods, we have developed a set of new reactions enabling the addition of pronucleophiles to alkynes and allenes furnishing branched allylic derivatives in a completely atom-economic fashion under neutral conditions. By choice of the right catalyst, a wide range of regio- and stereoselective C/O, C/N, C/S and C/C-bond-forming reactions could be achieved. Applications in target-oriented synthesis will also be presented. Furthermore, new C/C-bond forming reactions involving Metallo/Photoredox Catalysis will be presented.