【7th July】International Workshop on Chiral Chemistry and Materials
日期：2013-07-07
阅读：1226
活动主题：International Workshop on Chiral Chemistry and Materials
Organized by Institute of Chiral Chemistry and Technology (ICCT) of School of Chemistry and Chemical Engineering
Organized by Institute of Chiral Chemistry and Technology (ICCT) of School of Chemistry and Chemical Engineering
活动时间：2013年7月7日9:00-13:00
活动地点：交通大学闵行校区化工学院526室
Program
July 7
09:00-09:10 Opening remarks (Prof. Shunai Che, Prof. Yoshio Okamoto)
Chair: Prof. Zhaoguo Zhang
09:10-10:00 Prof. Yoshio Okamoto (Nagoya University and Harbin Engineering University)
10:00-10:50 Prof. Laurence A. Nafie (Department of Chemistry, Syracuse University)
10:50-11:10 Break
09:00-09:10 Opening remarks (Prof. Shunai Che, Prof. Yoshio Okamoto)
Chair: Prof. Zhaoguo Zhang
09:10-10:00 Prof. Yoshio Okamoto (Nagoya University and Harbin Engineering University)
10:00-10:50 Prof. Laurence A. Nafie (Department of Chemistry, Syracuse University)
10:50-11:10 Break
Chair: Prof. Changming Dong, Yongjian Zhang
11:10-11:20 Prof. Zhaoguo Zhang (ICCT, SJTU)
11:20-11:30 Prof. Yongjian Zhang (ICCT, SJTU)
11:30-11:40 Prof. Weidong Zhang (ICCT, SJTU)
11:40-11:50 Prof. Daxiang Cui (ICCT, SJTU)
11:50-12:00 Prof. Shouwu Guo (ICCT, SJTU)
12:00-12:10 Prof. Chuanliang Feng (ICCT, SJTU)
12:10-12:20 Prof. Xinyuan Zhu (ICCT, SJTU)
12:20-12:30 Prof. Changming Dong (ICCT, SJTU)
11:10-11:20 Prof. Zhaoguo Zhang (ICCT, SJTU)
11:20-11:30 Prof. Yongjian Zhang (ICCT, SJTU)
11:30-11:40 Prof. Weidong Zhang (ICCT, SJTU)
11:40-11:50 Prof. Daxiang Cui (ICCT, SJTU)
11:50-12:00 Prof. Shouwu Guo (ICCT, SJTU)
12:00-12:10 Prof. Chuanliang Feng (ICCT, SJTU)
12:10-12:20 Prof. Xinyuan Zhu (ICCT, SJTU)
12:20-12:30 Prof. Changming Dong (ICCT, SJTU)
12:30-12:40 Closing remarks (Prof. Wanbin Zhang, Prof. Laurence A. Nafie)
12:40-13:30 Lunch
Separation of Enantiomers by HPLC Using Helical Polymers
Yoshio Okamoto (Nagoya University and Harbin Engineering University)
Yoshio Okamoto (Nagoya University and Harbin Engineering University)
Separation of enantiomers is of importance to study and develop chiral compounds. One of practically useful enantioseparation methods is the separation by chromatography, particularly by HPLC using chiral stationary phases (CSPs). In this method, the development of efficient CSPs is the key. In my lecture, separation of enantiomers by HPLC using the helical polymers including polymethacrylates, poly(phenylacetylene)s and polysaccharide derivatives, which were investigated in my group, will be mainly discussed. Some of these CSPs have been most frequently used not only for analyzing optically active compounds but also for obtaining them.
Yoshio Okamoto简介
Distinguished Invited University Professor
(Professor Emeritus) of Nagoya University, Japan
Chair Professor of Harbin Engineering University, China
(Professor Emeritus) of Nagoya University, Japan
Chair Professor of Harbin Engineering University, China
#1E Omuramiyahigashi Mansion,
27 Miyahigashi-cho, Showa-ku, NAGOYA 466-0804, JAPAN
Tel/FAX: 81-52-753-7292
E-mail: okamotoy2012@gmail.com 该E-mail地址已受到防止垃圾邮件机器人的保护，您必须启用浏览器的Java Script才能看到。 , okamoto@apchem.nagoya-u.ac.jp 该E-mail地址已受到防止垃圾邮件机器人的保护，您必须启用浏览器的Java Script才能看到。
27 Miyahigashi-cho, Showa-ku, NAGOYA 466-0804, JAPAN
Tel/FAX: 81-52-753-7292
E-mail: okamotoy2012@gmail.com 该E-mail地址已受到防止垃圾邮件机器人的保护，您必须启用浏览器的Java Script才能看到。 , okamoto@apchem.nagoya-u.ac.jp 该E-mail地址已受到防止垃圾邮件机器人的保护，您必须启用浏览器的Java Script才能看到。
Education
March 1964
B.S. degree (Department of Polymer Science, Faculty of Science, Osaka University (Prof. S. Murahashi))
March 1966
M.S. degree (The same department (Prof. H. Yuki))
March 1969
Dr. degree (The same department (Prof. H. Yuki))
March 1964
B.S. degree (Department of Polymer Science, Faculty of Science, Osaka University (Prof. S. Murahashi))
March 1966
M.S. degree (The same department (Prof. H. Yuki))
March 1969
Dr. degree (The same department (Prof. H. Yuki))
Brief Professional History
April 1969-1983
Assistant Professor (Department of Chemistry, Faculty of Engineering Science, Osaka University)
(September 1970-August 1972)
Research Associate (University of Michigan, Prof. Overberger)
August 1983-1990
Associate Professor
March 1990-1997
Professor (Nagoya University, School of Engineering)
March 1997-March 2004
Professor (Nagoya University, Graduate School of Engineering)
April 1998-March 2000
Director of Venture Business Laboratory (Nagoya University)
April 2004-March 2009
Guest Professor (Nagoya University, EcoTopia Science Institute)
April 2004~
Emeritus Professor of Nagoya University
May 2004-May 2006
President, The Society of Polymer Science, Japan
June 2005-March 2011
Research Supervisor, JST-PREST \"Structure Control and Function\"
March 2006-September 2011
Associate Member of Science Council of Japan
June 2007-March 2009
Vice President of Chemical Union of Japan Science and Technology
August 2007~
Chair Professor of Harbin Engineering University
July 2009~
Distinguished Invited University Professor (Nagoya University)
April 1969-1983
Assistant Professor (Department of Chemistry, Faculty of Engineering Science, Osaka University)
(September 1970-August 1972)
Research Associate (University of Michigan, Prof. Overberger)
August 1983-1990
Associate Professor
March 1990-1997
Professor (Nagoya University, School of Engineering)
March 1997-March 2004
Professor (Nagoya University, Graduate School of Engineering)
April 1998-March 2000
Director of Venture Business Laboratory (Nagoya University)
April 2004-March 2009
Guest Professor (Nagoya University, EcoTopia Science Institute)
April 2004~
Emeritus Professor of Nagoya University
May 2004-May 2006
President, The Society of Polymer Science, Japan
June 2005-March 2011
Research Supervisor, JST-PREST \"Structure Control and Function\"
March 2006-September 2011
Associate Member of Science Council of Japan
June 2007-March 2009
Vice President of Chemical Union of Japan Science and Technology
August 2007~
Chair Professor of Harbin Engineering University
July 2009~
Distinguished Invited University Professor (Nagoya University)
Society Membership
The Chemical Society of Japan
The Society of Polymer Science, Japan (President: May, 2004-May, 2006)
The Pharmaceutical Society of Japan
The Japan Society for Analytical Chemistry
American Chemical Society
The Chemical Society of Japan
The Society of Polymer Science, Japan (President: May, 2004-May, 2006)
The Pharmaceutical Society of Japan
The Japan Society for Analytical Chemistry
American Chemical Society
Awards and Honors
* Award of the Society of Polymer Science, Japan (1982)
* Award of the Society of Fiber Science and Technology, Japan for Technical Development
(1987)
* The Chemical Society of Japan Award for Technical Development (1991)
* Loui Vuitton, \"Vinci of Excellence\" (1996)
* Award of The Chemical Society of Japan (1999)
* Molecular Chirality Award (1999)
* Chirality Medal (2001)
* Medal with Purple Ribbon (Japanese Government) (2002. Spring)
* Fujiwara Prize (2005)
* Thomson Scientific Research Front Award 2007 (2007)
* SPSJ Award for Outstanding Achievement of Polymer Science and Technology (2009)
* Ryoji Noyori Prize sponsored by Takasago International Corporation and administered by
the Society of Synthetic Organic Chemistry, Japan (2010)
* Honorary Member of SPSJ (2011)
* Honorary Professor of Beijing University of Chemical Technology (2011)
* University of Michigan and ACS \"Charles G. Overberger International Prize in Polymer
Science\" (2011)
* Award of the Society of Polymer Science, Japan (1982)
* Award of the Society of Fiber Science and Technology, Japan for Technical Development
(1987)
* The Chemical Society of Japan Award for Technical Development (1991)
* Loui Vuitton, \"Vinci of Excellence\" (1996)
* Award of The Chemical Society of Japan (1999)
* Molecular Chirality Award (1999)
* Chirality Medal (2001)
* Medal with Purple Ribbon (Japanese Government) (2002. Spring)
* Fujiwara Prize (2005)
* Thomson Scientific Research Front Award 2007 (2007)
* SPSJ Award for Outstanding Achievement of Polymer Science and Technology (2009)
* Ryoji Noyori Prize sponsored by Takasago International Corporation and administered by
the Society of Synthetic Organic Chemistry, Japan (2010)
* Honorary Member of SPSJ (2011)
* Honorary Professor of Beijing University of Chemical Technology (2011)
* University of Michigan and ACS \"Charles G. Overberger International Prize in Polymer
Science\" (2011)
Editor and Editorial Board
*Chirality (Editorial Board, 1989-)
*Polymer Journal (Associate Editor, 1994-2004)
*Reactive Polymer (Editorial Board, 1995-2005)
*Enantiomer (Associate Editor, 1995-2001)
*Polymer (Editorial Board, 2000-2003 )
*J. Polym. Sci. Part A. Polym. Chem. (Editorial Board, 2001- )
*Bulletin of the Chemical Society of Japan (Advisory Board, 2005.4-)
Main Research Subject
*Control of polymerization reactions
*Asymmetric polymerization
*Optically active polymers
*Optical resolution by chromatography
Publications
*484 Original papers
*151 Chapter books & Reviews
*Chirality (Editorial Board, 1989-)
*Polymer Journal (Associate Editor, 1994-2004)
*Reactive Polymer (Editorial Board, 1995-2005)
*Enantiomer (Associate Editor, 1995-2001)
*Polymer (Editorial Board, 2000-2003 )
*J. Polym. Sci. Part A. Polym. Chem. (Editorial Board, 2001- )
*Bulletin of the Chemical Society of Japan (Advisory Board, 2005.4-)
Main Research Subject
*Control of polymerization reactions
*Asymmetric polymerization
*Optically active polymers
*Optical resolution by chromatography
Publications
*484 Original papers
*151 Chapter books & Reviews
Patent Applied in Japan: 175
Patent Applied in US and EU: 65
Patent Applied in US and EU: 65
Enhanced Vibrational Optical Activity:
From Resonance ROA to VCD of Protein Fibrils
From Resonance ROA to VCD of Protein Fibrils
Laurence A. Nafie
Department of Chemistry, Syracuse University,
Syracuse, New York, USA, 13244
Department of Chemistry, Syracuse University,
Syracuse, New York, USA, 13244
Typical intensities of vibrational optical activity (VOA) are four of five orders of magnitude smaller that the parent Raman or infrared absorption intensity [1]. As a result, there is considerable interest in unusually large VOA intensities owing to their relative ease of measurement. After describing the basic principles of VCD and ROA measurement, calculation, and pharmaceutical application, the origins enhanced ROA and VCD spectra will be described. One area of particular interest and biomedical relevance is the VCD of amyloid fibril solutions and films. Intense VCD associated with the formation and growth of amyloid protein fibrils was first reported in 2007 [2] and is significant due to the association of protein fibrils with the development of many neurodegenerative diseases. An unexpected sign reversal of the enhanced VCD has been observed for insulin fibrils implying a complete reversal of the supramolecular structure during insulin fibril development. It was found that the sign of the VCD and hence fibril supramolecular chirality can be controlled by small changes in the pH of the incubating solution [3], and fibril chirality has been shown to spontaneously reverse by raising the pH after fibril formation [4]. These observations of pH control of fibril chirality have been extended to many other proteins, including prion proteins, and it has been found that the supramolecular chirality of VCD correlates directly to two major classes of fibril morphology, twisted-braided fibrils (normal chirality) and flat tape-like fibrils (reversed chirality) where such morphological differences are known to differ in their bio-toxicological effects.
[1] L. A. Nafie, Vibrational Optical Activity: Principles and Applications, Wiley, Chichester, 2011.
[2] S. Ma, X. Cao, M. Mak, A. Sadik, C. Walkner, T. B. Freedman, I. Lednev, R. K. Dukor and L. A. Nafie, J. Am. Chem. Soc. 129, 12364-12365 (2007).
[3] D. Kurouski, R. A. Lombardi, R. K. Dukor, I. K. Lednev and L. A. Nafie, Chem Comm. 46, 7154-7156 (2010).
[4] D. Kurouski, R. K. Dukor, X. Lu, L. A. Nafie and Igor K. Lednev, Chem Comm. 48, 2837-2839 (2012).
[2] S. Ma, X. Cao, M. Mak, A. Sadik, C. Walkner, T. B. Freedman, I. Lednev, R. K. Dukor and L. A. Nafie, J. Am. Chem. Soc. 129, 12364-12365 (2007).
[3] D. Kurouski, R. A. Lombardi, R. K. Dukor, I. K. Lednev and L. A. Nafie, Chem Comm. 46, 7154-7156 (2010).
[4] D. Kurouski, R. K. Dukor, X. Lu, L. A. Nafie and Igor K. Lednev, Chem Comm. 48, 2837-2839 (2012).
Laurence A. Nafie
Emeritus Distinguished Professor
Department of Chemistry, Syracuse University
Syracuse, New York, 13244-4100
Email: LNAFIE@SYR.EDU 该E-mail地址已受到防止垃圾邮件机器人的保护，您必须启用浏览器的Java Script才能看到。
Website: http://chemistry.syr.edu/faculty/nafie.html
Emeritus Distinguished Professor
Department of Chemistry, Syracuse University
Syracuse, New York, 13244-4100
Email: LNAFIE@SYR.EDU 该E-mail地址已受到防止垃圾邮件机器人的保护，您必须启用浏览器的Java Script才能看到。
Website: http://chemistry.syr.edu/faculty/nafie.html
Laurence A. Nafie received his Ph.D. from the University of Oregon in 1973 and until 1975 was a postdoctoral associate at the University of Southern California where he confirmed the discovery of vibrational circular dichroism (VCD). He then joined the Chemistry faculty at Syracuse University to establish a research program in VCD and Raman optical activity (ROA). In 1978, he was named an Alfred P. Sloan Fellow and was promoted to Professor in 1982 and Distinguished Professor in 2000. In 1978 he first measured the Fourier transform VCD now used in all commercial VCD instrumentation. In 1988 he measured scattered circular polarization (SCP) ROA used for all commercial ROA spectrometers. In 1996, he co-founded BioTools to market chiral and biological spectroscopic instrumentation, including VCD and ROA spectrometers. He was awarded the Coblentz Award (1981), the Bomem Michelson Award (2001), the William F. Meggers Award (2001) and the Pittsburgh Spectroscopy Award (2013). He was President of the Society of Applied Spectroscopy in 2003 and in 2008 became a Society Fellow. In 2010 he retired from Syracuse University to become Emeritus Distinguished Professor and Editor-in-Chief of the Journal of Raman Spectroscopy. In 2011 he published a book entitled Vibrational Optical Activity: Principles and Applications. He has over 290 publications and several patents.
