2023.06-2026.06 上海交通大学转化医学研究院 博士后

2019.09-2023.06 上海交通大学 化学 博士研究生

2016.09-2019.03 上海交通大学 化学 硕士研究生

2012.09-2016.06 广西大学 化学 本科

1、有机硅合成方法学研究（新型催化剂设计与合成、功能有机硅材料设计与合成）

2、有机硼合成方法学研究（硼中子俘获治疗BNCT药物设计与合成）

3、过渡金属不对称催化方法学研究（不对称氢化）

1、精准递送硼药靶向黑色素瘤硼中子俘获治疗的机制研究（国家转化医学科学中心（上海），重点研发计划）

2、多羰基化合物不对称氢化反应中化学、 区域及对映选择性控制研究（国家自然科学基金项目）

发表论文：

1、Wu, X.; Liu, W.; Yang, L.; Wang, Y.; Liu, T.; Yuan, Y.; Lu, Y.; Zhang, Z. Nickel-Catalyzed Regioselective Hydrosilylation of Conjugated Dienes. Chin. J. Chem . 2024, 42, 13–19.

2、Wu, X.; Wang, Y.; Yang, L.; Xie, X.; Zhang, Z. Transition-metal-free chemoselective catalytic hydrosilylation of tertiary amides to hemiaminals by Me2SiH2 generated from controllable disproportionation of 1,1,3,3-tetramethyldisiloxane. Org. Chem. Front. 2023, 10, 1198–1205. 

3、Wu, X.; Ding, G.; Lu, W.; Yang, L.; Wang, J.; Zhang, Y.; Xie, X.; Zhang, Z. Nickel-Catalyzed Hydrosilylation of Terminal Alkenes with Primary Silanes via Electrophilic Silicon–Hydrogen Bond Activation. Org. Lett. 2021, 23, 1434–1439.

4、Wu, X.; Ding, G.; Yang, L.; Lu, W.; Li, W.; Zhang, Z.; Xie, X. Alkoxide-Catalyzed Hydrosilylation of Cyclic Imides to Isoquinolines via Tandem Reduction and Rearrangement. Org. Lett. 2018, 20, 5610–5613.

5、Yi, M.; Wu, X.; Wu, J.; Lu, Y.; Zhang, Z. Photocatalytic α-Selective σ-Bond Hydroboration of Bicyclo[1.1.0]butanes. Org. Lett. 2026, 28, 1851–1856.

6、Yi, M.; Wu, X.; Yang, L.; Yuan, Y.; Lu, Y.; Zhang, Z. Visible Light Induced B–H Bond Insertion Reaction with Diazo Compounds. J. Org. Chem. 2024, 89, 12583–12590.

7、Yang, L.; Lu, W.; Wu, X.; Lu, Y.; Xie, X.; Zhang, Z. Regio- and stereoselective hydrosilylation of alkynes with alkoxysilanes for the synthesis of β-(Z) vinylsilanes catalyzed by a dirhodium(ii)/XantPhos complex. Org. Chem. Front. 2024, 11, 448–457

8、Yang, L.; Yi, M.; Wu, X.; Lu, Y.; Zhang, Z. Dirhodium(II)/XantPhos Catalyzed Synthesis of β-(E)-Vinylsilanes via Hydrosilylation and Isomerization from Alkynes. Chem. Eur. J. 2024, 30, e202402406.

9、Yang, L.; Wu, X.; Lu, W.; Lu, Y.; Zhang, Z. Dirhodium(II)/DPPM Catalyzed 1,2-Hydrosilylation of Conjugated Dienes with Tertiary Silanes. Org. Lett. 2024, 26, 2287–2291.

10、Wang, Y.; Wu, X.; Yang, L.; Liu, W.; Zhang, Z.; Xie, X. Sequential KOtBu/FeCl3-catalyzed reductive phosphonylation of tertiary amides for the synthesis of α-amino phosphonates and phosphines. Org. Biomol. Chem. 2023, 21, 2955–2959. 

11、Liu, W.; Lu, W.; Yang, L.; Wu, X.; Zhang, Z. Rhodium-catalyzed anti-Markovnikov hydrosilylation of alkenes. Tetrahedron 2022, 109, 132632.

12、Ding, G.; Wu, X.; Jiang, L.; Zhang, Z.; Xie, X. Reduction of Benzolactams to Isoindoles via an Alkoxide-Catalyzed Hydrosilylation. Org. Lett. 2017, 19, 6048–6051.

13、Lu, W.; Li, C.; Wu, X.; Xie, X.; Zhang, Z. [Rh(COD)Cl]2/PPh3-Catalyzed Dehydrogenative Silylation of Styrene Derivatives with NBE as a Hydrogen Acceptor. Organometallics 2020, 39, 3780–3788.

14、Lu, W.; Zhu, X.; Yang, L.; Wu, X.; Xie, X.; Zhang, Z. Distinct Catalytic Performance of Dirhodium(II) Complexes with ortho-Metalated DPPP in Dehydrosilylation of Styrene Derivatives with Alkoxysilanes. ACS Catal. 2021, 11, 10190–10197.

15、Lu, B.; Wu, X.; Li, C.; Ding, G.; Li, W.; Xie, X.; Zhang, Z. Highly Diastereo- and Enantioselective Access to syn-α-Amido β-Hydroxy Esters via Ruthenium-Catalyzed Dynamic Kinetic Resolution-Asymmetric Hydrogenation. J. Org. Chem. 2019, 84, 3201–3213.

16、Ding, G.; Wu, X.; Lu, B.; Lu, W.; Zhang, Z.; Xie, X. Tri(pentaflurophenyl)borane-catalyzed reduction of cyclic imides with hydrosilanes: Synthesis of pyrrolidines. Tetrahedron 2018, 74, 1144–1150.

17、Ding, G.; Wu, X.; Jiang, L.; Zhang, Z.; Xie, X. Reduction of Benzolactams to Isoindoles via an Alkoxide-Catalyzed Hydrosilylation. Org. Lett. 2017, 19, 6048–6051.

专利及专著：

1、Wu, X.; Zhang, Z.; Giese, B.; Dickhaut, J.; Chatgilialoglu, C. Tris(trimethylsilyl)silane. In Encyclopedia of Reagents for Organic Synthesis, 2022; pp 1–11.(https://doi.org/10.1002/047084289X.rt420.pub3)

2、吴啸宇，张兆国，卢岩，一种高硼原子利用率的4-10B-硼酸-L-苯丙氨酸的生产方法，CN120463733A，公布日期：2025-08-12。(发明专利)