电子邮件:wenmaohuang@sjtu.edu.cn
2013.09−2017.06 南京大学,物理学,博士,导师:王炜教授、曹毅教授
2009.09−2013.06 南京大学,物理学(生物物理),学士
2023.11至今 上海交通大学,化学化工学院,长聘教轨副教授
2020.01−2023.10 新加坡国立大学,物理系和力生物学研究所,博士后,合作导师:Jie Yan 教授
2017.07−2019.12 南京大学,化学化工学院,博士后,合作导师:曹毅 教授
化学、物理和生物交叉的单分子和单细胞力学:
1)发展单分子和单细胞力学技术(基于原子力显微镜、磁镊、玻璃微管和微流控的多尺度力学技术);
2)发展宏量和高通量力学技术,结合机器学习,实现分子和细胞力学编程;
3)研究机械力介导的化学反应(力增强反应;力化学生物学;高分子物理和力化学;核酸力化学)
4)研究机械力调控的分子和细胞生物学(力生物学;生物大分子的力致构象转变、相互作用与黏附;蛋白质错误折叠与神经退行性疾病)
2023 国家海外高层次引进人才计划
2023 上海市海外高层次引进人才计划
2025-2029 国自然面上项目
2025-2028 国家重点研究计划 培育项目
1. Wenmao Huang, et al. Ions shaping the mechanics of chromosomes in mitosis, Nat. Mater. 2024, 23, 1468–1470
2. Linfeng Yang,..., Chunhai Fan*, Wenmao Huang*. DNA Mechanics: From Single Stranded to Self-Assembled. Nano Letts, 2024, 24, 38, 11768-11778
before SJTU:
1. Wenmao Huang*, et al. In situ single-molecule investigations of the impacts of biochemical perturbations on conformational intermediates
of monomeric α-synuclein. APL Bioengineering, 2024, 8 (1) (一作+共通,Featured Article)
2. Chaoyu Fu#, Wenmao Huang#, et al., Unveiling Mechanical Activation: GAIN Domain Unfolding and Dissociation in Adhesion GPCRs.
Nano. Lett.. 2023, 23, 20, 9179–9186.
3. Wenmao Huang, et al. Mechanical stabilization of a bacterial adhesion complex. J. Am. Chem. Soc., 2022, 144, 37, 16808-16818.
4. Wenmao Huang, et al. Maleimide–thiol adducts stabilized through stretching. Nat. Chem., 2019, 11, 310–319.
(Highlighted by Nat. Chem. "Pulling together to improve stability").
5. Weishuai Di#, Xiang Gao#, Wenmao Huang#, et al. Direct measurement of length scale dependence of the hydrophobic free energy of
a single collapsed polymer nanosphere. Phys. Rev. Lett., 2019, 122, 047801.
6. Wenmao Huang#, Zhenshu Zhu#, Jing Wen#, et al. Single Molecule Study of Force-Induced Rotation of Carbon–Carbon Double Bonds in Polymers.
ACS Nano, 2017, 1, 194-203 (Highlighted by “Twist and Shout: Single-Molecule Mechanochemistry”).
7. Xingdong Guo#, Chengsong Yan#, Hua Li#, Wenmao Huang#, et al. Lipid-dependent conformational dynamics underlie the functional versatility of
T-cell receptor. Cell Res., 2017, 27, 505-525.
8. Wenmao Huang, et al. Profiling selective binding to promoter CpG islands by a single-DNA mechanical footprinting assay.
Biophys. J., 2021, 16, 3235-3236.
9. X. Wu#, Wenmao Huang#, W.-H. Wu# et al. Reversible hydrogels with tunable mechanical properties for optically controlling cell migration.
Nano Res., 2018, 11, 5556–5565.
10. Wenmao Huang, et al. Dimerization of cell-adhesion molecules can increase their binding strength. Langmuir, 2017, 6, 1398-1404.
书籍列表
11. Wenmao Huang, Yi Cao*, et al. Single-molecule Atomic Force Microscopy, 软物质前沿科学丛书, 2021 (基于原子力显微镜的单分子技术).
12. Wenmao Huang, Jie Yan*, et al. Micropipette-based single-cell mechanical quantification. Methods Mol. Biol. Springer, 2022
(基于玻璃微管的单细胞操控技术).
已发表文章列表(Google Scholar): https://scholar.google.com.sg/citations?user=HO5APLkAAAAJ&hl=zh-CN
Supramolecular Materials 青年编委(2024)
我们正在寻找各个阶段充满好奇心和探索热情的研究人员加入我们的团队!欢迎具有化学、物理、生物、医学、工程、计算机等
多学科背景的博士后、博士生、科研助理、硕士生和本科生加入我们团队,共同组建一个学科交叉、团结温馨、朝气蓬勃、富有创造力的研究团队。
让我们一起怀着好奇心,从物理学本质规律出发,通过操控与测量单个分子、单个细胞的力学行为,揭开隐藏在化学和生物学中的种种奥秘!
感兴趣的同学请将您的简历发送至我的邮箱 wenmaohuang@sjtu.edu.cn