张川长聘副教授

办公电话:021-54740717
电子邮件:chuanzhang@sjtu.edu.cn
通讯地址:上海市东川路800号化学化工学院
个人主页: www.zhangresearchgroup.com

  • 教育背景

    1999-2003:清华大学化学系,学士
    2003-2006:清华大学化学系,硕士,导师:朱永法教授
    2006-2011:美国普渡大学化学系,博士,导师:Professor Chengde Mao

  • 工作经历

    2011-2014:美国西北大学化学系,博士后,导师:Professor Chad A. Mirkin
    2014-至今:上海交通大学化学化工学院特别研究员

  • 研究方向

    1) 新型核酸药物、基因递送和治疗

    2) 药物递送系统、新型生物材料合成和应用

    3) 核酸纳米技术,生物大分子功能材料及纳米生物医学

  • 科研项目

    1. 国家自然科学基金杰出青年科学基金,“核酸药物递送系统”,2023/01-2027/12,主持。

    2. 国家自然科学基金面上项目,“硫代寡核苷酸-药物偶联物的合成、组装及其应用研究”,2020/01-2023/12,主持。

    3. 国家自然科学基金国际(地区)合作与交流项目(中港合作基金),“自组装DNA纳米结构高效基因载体的构建及其与细胞的相互作用”,2017/01-2020/12,主持。

    4. 国家自然科学基金面上项目,“DNA诱导新型纳米粒子超晶格材料组装及其性能研究”,2017/01-2020/12,主持。

    5. 国家重点研发计划课题,“新型高分子眼科功能性植入材料的研发和应用”课题二“眼眶软组织再生材料的研发与作用机制”2018/09-2022/06,课题负责人。

    6. 国家重点研发计划课题,“精确自组装”纳米存储基元的设计与合成”课题一“使用合成 DNA 进行数据存储的技术研发”,2019/07-2024/06,参与。

    7. 国家自然科学基金重大研究计划,“初级组装体的模块化组装、功能集成与仿生应用”,2016/01-2018/12,参与。

    8. 国家自然科学基金青年基金,“高密度核酸-聚酯胶束亲和杂化递送基因药物研究”,2016/01-2018/12,主持。



  • 代表性论文专著

    At SJTU (Selected)

    13) Yuanyuan Guo, Qiushuang Zhang, Qiwen Zhu, Jing Gao, Xinyuan Zhu, Haijun Yu,* Yuehua Li,* Chuan Zhang*, “Co-packaging photosensitizer and PD-L1 siRNA in a nucleic acid nanogel for synergistic cancer photoimmunotherapy”, Sci. Adv., 2022, 8, eabn2941.

    12) Lijuan Zhu, Jiapei Yang, Yuan Ma, Xinyuan Zhu, Chuan Zhang*, “Aptamers Entirely Built from Therapeutic Nucleoside Analogues for Targeted Cancer Therapy”, J. Am. Chem. Soc., 2022, 144, 1493-1497.

    11) Yuhe Liu, Jiao Zhang, Yuanyuan Guo, Ping Wang, Yue Su, Xin Jin, Xinyuan Zhu, Chuan Zhang*, “Drug-Grafted DNA as A Novel Chemogene for Targeted Combinatorial Cancer Therapy”, Exploration, 2022, 2, 20210172.

    10) Xihui Gao, Sha Li, Fei Ding, Xinlong Liu, Yijing Wu, Jing Li, Jing Feng*, Xinyuan Zhu, Chuan Zhang*, “Virus-Mimicking Nucleic Acid Nanogel Reprograms the Microglia and Macrophage for Glioblastoma Therapy”, Adv. Mater., 2021, 33, 2006116.

    9) Lijuan Zhu, Yuanyuan Guo, Qiuhui Qian, Deyue Yan, Yuehua Li, Xinyuan Zhu, Chuan Zhang*, “Carrier-Free Delivery of Precise Drug-Chemogene Conjugates for Synergistic Treatment of Drug-Resistant Cancer”, Angew. Chem. Int. Ed., 2020, 59, 17944-17950.

    8) Huan Ge, Dongya Wang, Yue Pan, Yuanyuan Guo, Hongyu Li, Fan Zhang, Xinyuan Zhu, Yuehua Li, Chuan Zhang*, Ling Huang*, “Sequence-Dependent DNA Functionalization of Upconversion Nanoparticles and Their Programmable Assemblies”, Angew. Chem. Int. Ed., 2020, 59, 8133-8137.

    7) Jiao Zhang, Yuanyuan Guo, Fei Ding, Gaifang Pan, Xinyuan Zhu, and Chuan Zhang*, “A Camptothecin-Grafted DNA Tetrahedron as Precise Nanomedicine to Inhibit the Tumor Growth”, Angew. Chem. Int. Ed., 2019, 58, 13794-13798.

    6) Xihui Gao, Sha Li, Fei Ding, Hongjia Fan, Leilei Shi, Lijuan Zhu, Jing Li, Jing Feng*, Xinyuan Zhu, Chuan Zhang*, “Rapid Detection of Exosomal microRNAs Using Virus-Mimicking Fusogenic Vesicles”, Angew. Chem. Int. Ed., 2019, 58, 8719-8723.

    5) Quanbing Mou, Yuan Ma, Fei Ding, Xihui Gao, Deyue Yan, Xinyuan Zhu, and Chuan Zhang*, “Two-in-One Chemogene Assembled from Drug-Integrated Antisense Oligonucleotides to Reverse Chemoresistance”, J. Am. Chem. Soc., 2019, 141, 6955-6966.

    4) Yuanyuan Guo, Jiao Zhang, Fei Ding, Gaifang Pan, Jing Li, Jing Feng, Xinyuan Zhu, and Chuan Zhang*, “Stressing the Role of DNA as Drug Carrier: Synthesis of the DNA-Drug Conjugates through Grafting Chemotherapeutics onto Phosphorothioate Oligonucleotides”, Advanced Materials, 2019, 31, 1807533.

    3) Ding F., Mou Q., Ma Y., Pan G., Guo Y., Tong G., Choi C. H. J., Zhu X., Zhang C.*, “Crosslinked Nucleic Acid Nanogel For Effective siRNA Delivery and Antitumor Therapy”, Angew. Chem. Int. Ed., 2018, 57, 3064-3068.

    2) Mou Q., Ma Y., Pan G., Xue B., Yan D., Zhang C.*, Zhu X.*, “DNA Trojan Horses: The Self-Assembled Floxuridine-Containing DNA Polyhedra for Cancer Therapy”, Angew. Chem. Int. Ed., 2017, 56, 12528–12532.

    1) Wang D., Liu B., Ma Y., Wu C., Mou Q., Deng H., Wang R., Yan D., Zhang C.*, Zhu X.*, “A molecular recognition approach to synthesize nucleoside analogue based multifunctional nanoparticles for targeted cancer therapy”, J. Am. Chem. Soc., 2017, 139, 14021-14024.


    Before SJTU (Selected)

    1) Zhang C., Li X., Tian C., Li. Y., Jiang W., Mao C.D.*, “DNA Nanocages Swallow Gold Nanoparticles (AuNPs) to Form AuNP@DNA Cage Core-Shell Structures”, ACS Nano 8, 1130-1135 (2014).
    2) Zhang C., Macfarlane R. J., Young K. L., Choi C. H. J., Hao L., Auyeung E., Liu G., Zhou X., Mirkin C. A.,* “A General Approach to DNA-Programmable Atom Equivalents”, Nat. Mater., 12, 741-746 (2013). 
    Also see: Simon U. “Nanoparticle self-assembly: Bonding them all”. Nat. Mater. 12, 694 (2013).Highlighted by C&EN, 21, 41 (2013).
    3) Zhang C., Tian C., Li X., Qian H., Hao C., Wang G., Jiang W., Mao C.D.*, “Reversibly Switching the Surface Porosity of a DNA Tetrahedron”, J. Am. Chem. Soc., 134, 11998-12001 (2012).
    4) Zhang C., Wu W.M., Li X., Tian C., Qian H., Wang G., Jiang W., Mao C.D.*, “Controlling the Chirality of DNA Nanocages”, Angew. Chem. Int. Ed., 51, 7999-8002 (2012).
    5) Zhang C., Tian C., Guo F., Liu Z., Jiang W., Mao C.D.*, “DNA-Directed Three Dimensional (3D) Protein Organization”, Angew. Chem. Int. Ed., 51, 3382-3385 (2012).
    6) Zhang C., He Y., Leng Y. J., Ribbe A.E., Jiang W., Mao C.D.*, “Exterior modification of a DNA tetrahedron”, Chem Comm., 46, 6792-6794 (2010).
    7) Zhang C., Ko S. H., Su M., Leng Y. J., Ribbe A.E., Jiang W., Mao C.D.*, “Symmetry Controls the Face Geometry of DNA Polyhedra”, J. Am. Chem. Soc., 131: 1413-1415 (2009).
    8) Zhang C., He Y., Mao C.D.*, “A Brief Review: DNA Nanocages Self-assembled by Star-shaped DNA Motifs”, Faraday Discuss., 143, 221-233 (2009).
    9) Zhang C., Mao C.D.*, “DNA Nanotechnology: Bacteria as factories”, Nat. Nanotech., 3: 707-708 (2008).
    10) Zhang C., Su M., He Y., Zhao X., Fang P.A., Ribbe A.E., Jiang W., Mao C.D.*; “Conformational Flexibility Facilitates Self-Assembly of Complex DNA Nanostructures”, Proc. Natl. Acad. Sci. USA, 105: 10665-10669 (2008).
    11) He Y., Ye T., Su M., Zhang C., Ribbe A.E., Jiang W., Mao C.D.*, “Hierarchical Self-assembly of DNA into Symmetric SupramolecularPolyhedra”, Nature, 452: 198-201 (2008).
    12) Zhang C., He Y., Chen Y., Ribbe A.E., Mao C.D.*; “Aligning One-dimensional DNA Duplexes into Two-dimensional Crystals” J. Am. Chem. Soc., 129: 14134-14135 (2007).
    13) Zhang C., Zhu Y.F.*, “Synthesis of Square Bi2WO6Nanoplates as High Activity Visible-Light-Driven Photocatalysts”, Chem. Mater., 17: 3537-3545 (2005).
    14) Zhang C., Wang L., Cui L.P., Zhu Y.F.*, “A Novel Method for The Synthesis of Nano-sized BaAl2O4 with Thermal Stability”, J. Cryst. Growth., 255: 317-323 (2003).

  • 学术兼职

    2019 – 至今     《高等化学学报》青年编委

    2018 – 至今     中国医药生物技术协会纳米生物技术分会委员会委员

    2018 – 至今     中国医药卫生事业发展基金会干眼防治专家委员会委员


  • 荣誉奖励

    1) 2014“求是青年学者”奖
    2) M.G. Mellon Award (2010)
    3) Bisland Fellowship (2009)

  • 人才需求

    本课题组欢迎对生物医用材料、核酸药物、基因治疗感兴趣的同学报考硕士、博士,以及开展博士后研究工作,具体可通过邮件联系,请发送至chuanzhang@sjtu.edu.cn

地址:上海市东川路800号 200240
电话:021-54742893
E-mail:sjtuscce@sjtu.edu.cn

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