张万斌教授

办公电话:021-54743265
电子邮件:wanbin@sjtu.edu.cn
通讯地址:上海市东川路800号上海交通大学化学化工学院B楼528室
个人主页: http://wanbin.sjtu.edu.cn/

  • 教育背景

    1981-1985:华东理工大学化学系,学士
    1985-1988:华东理工大学化学系,硕士
    1994-1997:日本大阪大学工学部应用化学系,博士 

  • 工作经历

    1988-1993:华东理工大学专用化学品研究所,助教、讲师

    1997-2001:日本大阪大学工学部应用化学系,助理教授

    2001-2003:日本三菱化学株式会社横滨综合研究所,主任研究员

    2003-2012:上海交通大学化学化工学院,教授

    2009-至今:上海交通大学药学院,教授

    2013-2021:上海交通大学,特聘教授

    2021-至今:上海交通大学,讲席教授

    2017-至今:上海市手性药物分子工程重点实验室,主任 

  • 研究方向

    1)有机合成及不对称催化
    2)药物及其关键中间体的高效合成方法

  • 科研项目

    主持和参加国家自然科学基金重大、重点、重点国际合作和面上项目、国家“重大新药创制”科技重大专项、教育部优秀青年教师资助计划项目、上海市科委、经信委和教委重大和重点科技攻关项目以及与国内外多家企业的产学研合作项目等多项课题研究。有多项成果获得了工业化应用。“青蒿素的高效合成”入选2012年国内十大科技新闻和2012年上海市十大科技成果。 

  • 代表性论文专著

    Biwen Li, Jianzhong Chen, Dan Liu, Ilya D. Gridnev, and Wanbin Zhang*, Nickel-catalysed asymmetric hydrogenation of oximes. Nat. Chem. 2022, online. DOI: 10.1038/s41557-022-00971-8. 


    Youbin Peng, Chongyu Han, Yicong Luo, Guanlin Li, XiaohongHuo, and Wanbin Zhang*, Nickel/Copper-Cocatalyzed Asymmetric Benzylation of Aldimine Esters for the Enantioselective Synthesis of α-Quaternary Amino Acids. Angew. Chem. Int. Ed. 2022, 61, e202203448. DOI:10.1002/anie.202203448.

     (Hot paper)


    Muxing Zhou, Yashi Zou, Lu Zhang, Zhenfeng Zhang, and Wanbin Zhang*, Chiral Bicyclic Imidazole-Catalyzed Direct Enantioselective C-Acetylation of Indolones. CCS Chem. 2022, accepted. DOI: 10.31635/ccschem.022.202201782.

     

    Cheng Sheng, Zheng Ling, Yicong Luo, and Wanbin Zhang*, Cu-catalyzed asymmetric addition of alcohols to β,γ-alkynyl-α-imino esters for the construction of linear chiral N,O-ketals. Nat. Commun. 2022, 13, 400. DOI: 10.1038/s41467-022-28002-7.

     

    Youbin Peng, Xiaohong Huo, Yicong Luo, Liang Wu, and Wanbin Zhang*, Enantio- and Diastereodivergent Synthesis of Spirocycles through Dual-Metal-Catalyzed [3+2] Annulation of 2-Vinyloxiranes with Nucleophilic Dipoles. Angew. Chem. Int. Ed. 2021, 60, 24941-24949. DOI: 10.1002/anie.202111842.

    (Hot paper)

     

    Yunnan Xu, Delong Liu, Yu Deng, Yi Zhou, and Wanbin Zhang*, Rh-Catalyzed Asymmetric Hydrogenation of 3-Benzoylaminocoumarins for the Synthesis of Chiral 3-Amino Dihydrocoumarins. Angew. Chem. Int. Ed. 2021, 60, 23602-23607. DOI: 10.1002/anie.202110286.

     

    Jiacheng Zhang, Xiaohong Huo, Junzhe Xiao, Ling Zhao, Shengming Ma*, and Wanbin Zhang*, Enantio- and Diastereodivergent Construction of 1,3-Nonadjacent Stereocenters Bearing Axial and Central Chirality through Synergistic Pd/Cu Catalysis. J. Am. Chem. Soc. 2021, 143, 12622-12632. DOI: 10.1021/jacs.1c05087.

     

    Jian Zhang, Tiantian Chen, Yuanhao Wang, Fengfan Zhou, Zhenfeng Zhang*, Ilya D. Gridnev*, and Wanbin Zhang*, Asymmetric Hydrogenation of γ-Branched Allylamines for the Efficient Synthesis of γ-Chirogenic Amines. Nat. Sci. 2021, e10021. DOI: 10.1002/ntls.10021.

    (Cover Picture Paper)

     

    Yanhua Hu, Zhenfeng Zhang, Yangang Liu, and Wanbin Zhang*, Cobalt-Catalyzed Chemo- and Enantioselective Hydrogenation of Conjugated Enynes. Angew. Chem. Int. Ed. 2021, 60, 16989-16993. DOI: 10.1002/anie.202106566.


    Xiaohong Huo, Ling Zhao, Yicong Luo, Yue Wu, Yuwen Sun, Guanlin Li, Tatiana Gridneva, Jiacheng Zhang, Yong Ye, and Wanbin Zhang*, Stereodivergent Pd/Cu Catalysis for Asymmetric Desymmetric Alkylation of Allylic Geminal Dicarboxylates. CCS Chem. 2021, 3, 1933-1944. DOI: 10.31635/ccschem.021.202101044.

     

    Chong Liu, Jing Yuan, Zhenfeng Zhang*, Ilya D. Gridnev, and Wanbin Zhang*, Asymmetric Hydroacylation Involving Alkene Isomerization for the Construction of C3-Chirogenic Center.
    Angew. Chem. Int. Ed. 2021, 60(16), 8997-9002. DOI: 10.1002/anie.202017190
    (Very Important Paper)

     

    Muxing Zhou, Tatiana Gridneva, Zhenfeng Zhang, Ende He, Yangang Liu, and Wanbin Zhang*, Chiral Bicyclic Imidazole-Catalyzed Acylative Dynamic Kinetic Resolution for the Synthesis of Chiral Phthalidyl Esters. Angew. Chem. Int. Ed. 2021, 60(3), 1641-1645. DOI: 10.1002/anie.202012445
    (Highlighted by SYNFACTS 2020, 16, 1466; Very Important Paper)

     

    Dan Liu, Bowen Li, Jianzhong Chen, Ilya D. Gridnev, Deyue Yan, and Wanbin Zhang*, Ni-Catalyzed Asymmetric Hydrogenation of N-Aryl Imino Esters for the Efficient Synthesis of Chiral α-Aryl Glycines. Nat. Commun. 2020, 11, 5935. DOI: 10.1038/s41467-020-19807-5
    (Highlighted by SYNFACTS 2021, 17, 0165)

     

    Mo Wang, Lu Zhang, Xiaohong Huo, Zhenfeng Zhang, Qianjia Yuan, Panpan Li, Jianzhong Chen, Yashi Zou, Zhengxing Wu, and Wanbin Zhang*, Catalytic Asymmetric Synthesis of the anti-COVID-19 Drug Remdesivir. Angew. Chem. Int. Ed. 2020, 59(47), 20814-20819. DOI: 10.1002/anie.202011527
    (Highlighted by SYNFACTS 2020, 16, 1350; Very Important Paper; Frontispiece)

     

    Rui He, Xiaohong Huo, Ling Zhao, Feijun Wang, Liyin Jiang, Jian Liao*, and Wanbin Zhang*, Stereodivergent Pd/Cu Catalysis for the Dynamic Kinetic Asymmetric Transformation of Racemic Unsymmetrical 1,3-Disubstituted Allyl Acetates. J. Am. Chem. Soc. 2020, 142(18), 8097-8103.
    DOI: 10.1021/jacs.0c02150
    (Highlighted by
    有机化学 2020, 40, 2161)

     

    Guanlin Li, Xiaohong Huo, Xieyang Jiang, and Wanbin Zhang*, Asymmetric Synthesis of Allylic Compounds via Hydrofunctionalisation and Difunctionalisation of Dienes, Allenes, and Alkynes. Chem. Soc. Rev. 2020, 49(7), 2060-2118. DOI: 10.1039/c9cs00400a
    (ESI Highly Cited Paper; Inside Front Cover)

     

    Yawen Hu, Jianzhong Chen, Bowen Li, Zhenfeng Zhang, Ilya D. Gridnev, and Wanbin Zhang*, Nickel-Catalyzed Asymmetric Hydrogenation of 2-Amidoacrylates. Angew. Chem. Int. Ed. 2020, 59(13), 5371-5375. DOI: 10.1002/anie.201916534

     

    Liang Wu, Guoqiang Yang, and Wanbin Zhang*, Ni-Catalyzed Enantioconvergent Coupling of Epoxides with Alkenylboronic Acids: Construction of Oxindoles Bearing Quaternary Carbons. CCS Chem. 2020, 2(2), 623-631. DOI: 10.31635/ccschem.019.201900064

     

    Yanhua Hu, Zhenfeng Zhang, Jian Zhang, Yangang Liu, Ilya D. Gridnev, and Wanbin Zhang*, Cobalt-Catalyzed Asymmetric Hydrogenation of C=N Bonds Enabled by Assisted Coordination and Nonbonding Interactions. Angew. Chem. Int. Ed. 2019, 58(44), 15767-15771. DOI: 10.1002/anie.201909928
    (Highlighted by SYNFACTS 2019, 15, 1381 and selected as Synfact of the month)

     

    Jian Zhang, Jia Jia, Xincheng Zeng, Yuanhao Wang, Zhenfeng Zhang, Ilya D. Gridnev, and Wanbin Zhang*, Chemo- and Enantioselective Hydrogenation of α-Formyl Enamides: An Efficient Access to Chiral α-Amido Aldehydes. Angew. Chem. Int. Ed. 2019, 58(33), 11505-11512. DOI: 10.1002/anie.201905263
    (Highlighted by Advances In ENGINEERING; Very Important Paper)

     

    Bowen Li, Jianzhong Chen, Zhenfeng Zhang, Ilya D. Gridnev, and Wanbin Zhang*, Nickel-Catalyzed Asymmetric Hydrogenation of N-Sulfonyl Imines. Angew. Chem. Int. Ed. 2019, 58(22), 7329-7334. DOI: 10.1002/anie.201902576
    (Very Important Paper; Inside Back Cover)

     

    Jianzhong Chen, Zhenfeng Zhang, Bowen Li, Feilong Li, Yulin Wang, Min Zhao, Ilya D. Gridnev, Tsuneo Imamoto, and Wanbin Zhang*, Pd(OAc)2-Catalyzed Asymmetric Hydrogenation of Sterically Hindered N-Tosylimines. Nat. Commun. 2018, 9, 5000. DOI: 10.1038/s41467-018-07462-w

     

    Xuezhen Kou, Qihang Shao, Chenghao Ye, Guoqiang Yang*, and Wanbin Zhang*, Asymmetric Aza-Wacker-Type Cyclization of N-Ts Hydrazine-Tethered Tetrasubstituted Olefins: Synthesis of Pyrazolines Bearing One Quaternary or Two Vicinal Stereocenters. J. Am. Chem. Soc. 2018, 140(24), 7587-7597. DOI: 10.1021/jacs.8b02865
    (Highlighted by SYNFACTS 2018, 14, 0840)

     

    Mao Quan, Xiaoxiao Wang, Liang Wu, Ilya D. Gridnev, Guoqiang Yang*, and Wanbin Zhang*, Ni(II)-Catalyzed Asymmetric Alkenylations of Ketimines. Nat. Commun. 2018, 9, 2258. DOI: 10.1038/s41467-018-04645-3

     

    Guoqiang Yang and Wanbin Zhang*, Renaissance of Pyridine-Oxazolines as Chiral Ligands for Asymmetric Catalysis. Chem. Soc. Rev. 2018, 47(5), 1783-1810. DOI: 10.1039/c7cs00615b
    (Back Cover)

     

    Xiaohong Huo, Jiacheng Zhang, Jingke Fu, Rui He, and Wanbin Zhang*, Ir/Cu Dual Catalysis: Enantio- and Diastereodivergent Access to α,α-Disubstituted α-Amino Acids Bearing Vicinal Stereocenters. J. Am. Chem. Soc. 2018, 140(6), 2080-2084. DOI: 10.1021/jacs.8b00187
    (Highlighted by Organic Chemistry Portal; ESI Highly Cited Paper)

     

    Xiaohong Huo, Rui He, Jingke Fu, Jiacheng Zhang, Guoqiang Yang, and Wanbin Zhang*, Stereoselective and Site-Specific Allylic Alkylation of Amino Acids and Small Peptides via a Pd/Cu Dual Catalysis. J. Am. Chem. Soc. 2017, 139(29), 9819-9822. DOI: 10.1021/jacs.7b05460

    (Highlighted by SYNFACTS 2017, 13, 1049 and 有机化学 2017, 37, 2454)

     

    Zhenfeng Zhang, Nicholas A. Butt, and Wanbin Zhang*, Asymmetric Hydrogenation of Nonaromatic Cyclic Substrates. Chem. Rev. 2016, 116(23), 14769-14827. DOI: 10.1021/acs.chemrev.6b00564
    (ESI Highly Cited Paper)

     

    Xiaohong Huo, Rui He, Xiao Zhang, and Wanbin Zhang*, An Ir/Zn Dual Catalysis for Enantio- and Diastereodivergent α-Allylation of α-Hydroxyketones. J. Am. Chem. Soc. 2016, 138(35), 11093-11096. DOI: 10.1021/jacs.6b06156
    (Highlighted by SYNFACTS 2016, 12, 1153 and selected as Front Cover and Synfact of the month; Highlighted by Org. Process. Res. Dev. 2016, 20, 1691)

     

    Jianzhong Chen, Zhenfeng Zhang, Delong Liu, and Wanbin Zhang*, Palladium-Catalyzed Chemo- and Enantioselective CO Bond Cleavage of α-Acyloxy Ketones by Hydrogenolysis. Angew. Chem. Int. Ed. 2016, 55(29), 8444-8447. DOI: 10.1002/anie.201603590

    (Highlighted by SYNFACTS 2016, 12, 1047 and 有机化学 2016, 36, 1970)

     

    Nicholas A. Butt and Wanbin Zhang*, Transition Metal-Catalyzed Allylic Substitution Reactions with Unactivated Allylic Substrates. Chem. Soc. Rev. 2015, 44(22), 7929-7967. DOI: 10.1039/c5cs00144g
    (ESI Highly Cited Paper; Front Cover)

     

    Qiupeng Hu, Zhenfeng Zhang, Yangang Liu, Tsuneo Imamoto, and Wanbin Zhang*, ZnCl2-Promoted Asymmetric Hydrogenation of β-Secondary-Amino Ketones Catalyzed by a P-Chiral Rh–Bisphosphine Complex. Angew. Chem. Int. Ed. 2015, 54(7), 2260-2264. DOI: 10.1002/anie.201411384

    (Highlighted by SYNFACTS 2015, 11, 0411 and 有机化学 2015, 35, 1187)

     

    Xun-Xiang Guo*, Da-Wei Gu, Zhengxing Wu, and Wanbin Zhang*, Copper-Catalyzed C–H Functionalization Reactions: Efficient Synthesis of Heterocycles. Chem. Rev. 2015, 115(3), 1622-1651. DOI: 10.1021/cr500410y

    (入选2015年中国百篇最具影响国际学术论文; ESI Highly Cited Paper)

     

    Xiaohong Huo, Guoqiang Yang, Delong Liu, Yangang Liu, Ilya D. Gridnev*, and Wanbin Zhang*, Palladium-Catalyzed Allylic Alkylation of Simple Ketones with Allylic Alcohols and Its Mechanistic Study. Angew. Chem. Int. Ed. 2014, 53(26), 6776-6780. DOI: 10.1002/anie.201403410

     

    Yuanyuan Liu, Ilya D. Gridnev*, and Wanbin Zhang*, Mechanism of the Asymmetric Hydrogenation of Exocyclic α,β-Unsaturated Carbonyl Compounds with an Iridium/BiphPhox Catalyst: NMR and DFT Studies. Angew. Chem. Int. Ed. 2014, 53(7), 1901-1905. DOI: 10.1002/anie.201309677

     

    Jianzhong Chen, Delong Liu, Nicholas Butt, Chao Li, Dongyang Fan, Yangang Liu, and Wanbin Zhang*, Palladium-Catalyzed Asymmetric Hydrogenation of α-Acyloxy-1-arylethanones. Angew. Chem. Int. Ed. 2013, 52(44), 11632-11636. DOI: 10.1002/anie.201306231

    (Highlighted by SYNFACTS 2014, 10, 0064 and 有机化学 2013, 33, 2637)

     

    Guoqiang Yang and Wanbin Zhang*, A Palladium-Catalyzed Enantioselective Addition of Arylboronic Acids to Cyclic Ketimines. Angew. Chem. Int. Ed. 2013, 52(29), 7540-7544. DOI: 10.1002/anie.201302861
    (Highlighted by SYNFACTS 2013, 9, 1085)

     

    Yuanyuan Liu and Wanbin Zhang*, Iridium-Catalyzed Asymmetric Hydrogenation of α-Alkylidene Succinimides. Angew. Chem. Int. Ed. 2013, 52(8), 2203-2206. DOI: 10.1002/anie.201209126
    (Highlighted by SYNFACTS 2013, 9, 0506)

     

    Guoqiang Yang, Chaoren Shen, and Wanbin Zhang*, An Asymmetric Aerobic Aza-Wacker-Type Cyclization: Synthesis of Isoindolinones Bearing Tetrasubstituted Carbon Stereocenters. Angew. Chem. Int. Ed. 2012, 51(36), 9141-9145. DOI: 10.1002/anie.201203693
    (Highlighted by SYNFACTS 2012, 8, 1185)

     

    Xiaohu Zhao, Delong Liu, Hui Guo, Yangang Liu, and Wanbin Zhang*, C–N Bond Cleavage of Allylic Amines via Hydrogen Bond Activation with Alcohol Solvents in Pd-Catalyzed Allylic Alkylation of Carbonyl Compounds. J. Am. Chem. Soc. 2011, 133(48), 19354-19357. DOI: 10.1021/ja209373k
    (Highlighted by SYNFACTS 2012, 8, 0182 and Organic Chemistry Portal)

     

    Zhenfeng Zhang, Fang Xie, Jia Jia, and Wanbin Zhang*, Chiral Bicycle Imidazole Nucleophilic Catalysts: Rational Design, Facile Synthesis, and Successful Application in Asymmetric Steglich Rearrangement. J. Am. Chem. Soc. 2010, 132(45), 15939-15941. DOI: 10.1021/ja109069k
    (Highlighted by SYNFACTS 2011, 7, 0098 and
    有机化学 2011, 31, 274)

  • 学术兼职

    中国化学会高级会员

    美国化学会会员 

    日本近畿化学协会会员

    中国化学会有机化学委员会委员

    中国化学会均相催化委员会委员 

    上海市化学化工学会有机化学委员会委员
    上海市药学会药物化学委员会委员

    国家自然科学基金委员会化学部会评专家

    《中国医药工业杂志》副主编

    《化学学报》编委  

    《有机化学》编委 

    《应用技术学报》编委

    《Research on Chemical Intermediates》编委

    Pharmaceutical Fronts(Chinese Journal of Pharmaceuticals B)编委

    Chemistry—A European Journal 编委

    The Chemical Record 编委


    社会兼职

    上海市侨联常委

    上海交通大学侨联主席

  • 荣誉奖励

    1)1993.10-1997.3日本政府奖学金

    2)1995年中国专利局“中国专利十年成就展”银奖

    3)2001年日本油脂工业会馆奖

    4)2003年入选教育部“优秀青年教师资助计划”
    5)2006年上海交通大学优秀教师一等奖(10名)
    6)2008-2009年上海交通大学师德标兵(两年评一次5名)
    7)2011年上海交通大学最受研究生欢迎的导师(10名)
    8)2012年上海交通大学凯原十佳教师奖
    9)2012年上海市育才奖

    10)“青蒿素的高效合成”入选2012年国内十大科技新闻

    11)“青蒿素的高效合成”入选2012年上海市十大科技成果

    12)2013年上海交通大学特聘教授 
    13)2013年Thieme Chemistry Journal Award

    14)2013年全国归侨侨眷先进个人

    15)2013年上海市优秀博士学位论文指导教师 

    16)2014年上海市优秀学科带头人

    17)2015年中国百篇最具影响国际学术论文

    18)2015年上海市优秀博士学位论文指导教师

    19)2016年获国务院政府特殊津贴

    20)2016年上海领军人才

    21)2016年上海交通大学第一届研究生"学术之星"导师(10名)

    22)2017年RSC TOP1%高被引中国作者

    23)2018年上海交通大学优秀博士学位论文指导教师(13名)

    24)2018年上海交通大学教书育人奖集体奖二等奖(负责人)

    25)2019年Osaka University Global Alumni Fellow

    26)2019年上海市产学研合作优秀项目奖特等奖(第一完成人) 

    27)2019年上海交通大学教书育人奖二等奖 (个人)

    28)2020年上海市自然科学奖一等奖(第一完成人)

    29)2020年中国化学会首届会士

    30)2020年Japan Science Promotion Society (JSPS) Fellows

    31)2020年爱思唯尔中国高被引学者

    32)2020年RSC TOP1%高被引中国作者

    33)2021年上海交通大学科研成果二等奖(个人)

    34)上海交通大学2021年度教学成果奖特等奖(负责人)

    35)2021年上海交通大学就业引导名师

    36)2021年爱思唯尔中国高被引学者

    37)2021年上海职工劳动和技能竞赛(科创中心建设赛区)二等奖(第一完成人)

    38)2022年上海交通大学第二届“十大科技进展”(第一完成人)

  • 教学工作

    1)本科生:《有机化学》

    2)本科生(致远学院):《化学前沿》
    3)研究生:《高等有机化学》,《近代合成方法》 

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