陈志敏长聘(教轨)副教授

办公电话:021-54743472
电子邮件:chenzhimin221@sjtu.edu.cn
通讯地址:上海市东川路800号上海交通大学建工楼322A室,邮编:200240
个人主页: https://www.x-mol.com/groups/Chen_Zhimin323

  • 教育背景

    2005-2009 福州大学,理学学士
    2009-2014 兰州大学,理学博士,专业:有机化学,导师:涂永强院士

  • 工作经历

    2014.7-2017.11  上海交通大学,专职科研博士后,合作导师:涂永强院士

    2015.7-2017.8   美国犹他大学,博士后,导师:Prof. Matthew S. Sigman
    2017.12 -至今   上海交通大学化学化工学院,特别研究员,博士生导师

  • 研究方向

    1. 发展有机硫、硒化合物的不对称合成新策略;

    2. 设计、合成新型的手性硫、硒催化剂并研究其催化性能和机制;

    3. 设计、合成新型的硫、硒试剂并研究其反应活性;

    4. 开展有机硫、硒化合物的不对称合成策略在天然产物和药物分子合成中的应用;

    5. 开展手性硫、硒化合物的生物活性和功能应用研究。


  • 科研项目

    主持国家自然科学面上项目(2项)、青年基金(1项,已结题)、上海市教委(1项)、上海交通大学启动经费,功能有机分子化学国家重点实验室开放课题(2021-2023)。

  • 代表性论文专著

    27. Deng Zhu+, Lu Yu+, Hui-Yun Luo, Xiao-Song Xue*, Zhi-Min Chen*

    Atroposelective Electrophilic Sulfenylation of N-Aryl Aminoquinone Derivatives Catalyzed by Chiral SPINOL-Derived Sulfide

    Angew. Chem. Int. Ed. 2022, 61, e202211782 (Hot Paper, 10.1002/anie.202211782). 

    1662030985617463.png


    26. Hui-Yun Luo, Zi-Hao Li, Deng Zhu, Qin Yang, Ren-Fei Cao, Tong-Mei Ding, Zhi-Min Chen*

    Chiral Selenide/Achiral Sulfonic Acid Co-catalyzed Atroposelective Sulfenylation of Biaryl Phenols via a Desymmetrization/Kinetic Resolution Sequence

    J. Am. Chem. Soc. 2022, 144, 2943-2952.



    25. Xiao-Dong Liu+, Yicong Luo+, Xiaohong, Huo, Hui-Yun Luo, Ren-Fei Cao, Zhi-Min Chen*

    Chiral Sulfide/Phosphoric Acid Cocatalyzed Enantioselective Intermolecular Oxysulfenylation of Alkenes with Phenol and Alcohol O-nucleophiles

    CCS Chem., 2022, 4, 3342-3354.



    24. Yu-Yang Xie, Zhi-Min Chen,* Hui-Yun Luo, Hui Shao, Yong-Qiang Tu,* Xiaoguang Bao,* Ren-Fei Cao, Shu-Yu Zhang, Jin-Miao Tian

    Lewis Base/Brønsted Acid Cocatalyzed Enantioselective Sulfenylation/Semipinacol Rearrangement of Di- and Trisubstituted Allylic Alcohols

    Angew. Chem. Int. Ed. 2019, 58, 12491-12496. Featured by Benjamin List, Joyce A. A. Grimm in SYNFACTS 2019, 15, 1175.


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    23. Deng Zhu, Zhi-Min Chen*

    Application of Chiral Lewis Base/Brønsted Acid Synergistic Catalysis Strategy in Enantioselective Synthesis of Organic Sulfides 

    Chin. J. Org. Chem. 2022, 42, DOI: 10.6023/cjoc202208032 (invited submission)

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    22. Hui-Yun Luo, Yu-Yang Xie, Xu-Feng Song, Jia-Wei Dong, Deng Zhu, Zhi-Min Chen*

    Lewis base-catalyzed asymmetric sulfenylation of alkenes: construction of sulfenylated lactones and application to the formal syntheses of (-)-nicotlactone B and (-)-galbacin

    Chem. Commun., 2019, 55, 9367-9370.


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    21. Hui-Yun Luo, Jia-Wei Dong, Yu-Yang Xie, Xu-Feng Song, Deng Zhu, Tongmei Ding, Yuanyuan Liu,* Zhi-Min Chen*

    Lewis Base/Brønsted Acid Co-catalyzed Asymmetric Thiolation of Alkenes with Acid-Controlled Divergent Regioselectivity

    Chem. Eur. J. 2019, 25, 15411-15418.

     

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    20. Ren-Fei Cao+, Lu Yu+, Yu-Xuan Huo, Yao Li, Xiao-Song Xue, Zhi-Min Chen*

    Chiral Lewis Base Catalyzed Enantioselective Selenocyclization of 1,1-Disubstituted Alkenes: Asymmetric Synthesis of Selenium-Containing 4H-3,1-Benzoxazines

    Org. Lett. 2022, 24, 4093-4098.


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    19. Deng Zhu, Ai-Hui Ye, Zhi-Min Chen*

    N-Selenocyanato-dibenzenesulfonimide: a new electrophilic selenocyanation reagent (Feature Article, invited submission)

    Synthesis 2021, 53, 3744-3750.

     

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    18. Ai-Hui Ye, Ye Zhang, Yu-Yang Xie, Hui-Yun Luo, Jia-Wei Dong, Xiao-Dong Liu, Xu-Feng Song, Tongmei Ding, Zhi-Min Chen*

    TMSCl-Catalyzed Electrophilic Thiocyano Oxyfunctionalization of Alkenes Using N-Thiocyano-dibenzenesulfonimide

    Org. Lett., 2019, 21, 5106-5110.



    17. Xu-Feng Song,† Ai-Hui Ye,† Yu-Yang Xie, Jia-Wei Dong, Chao Chen, Ye Zhang,* Zhi-Min Chen* (†equal contribution)

    Lewis Acid Mediated Thiocyano Semipinacol Rearrangement of Allylic Alcohols for the Construction of α-Quaternary Center β-Thiocyano Carbonyls

    Org. Lett., 2019, 21, 9550-9554.



    16. Ai‐Hui Ye, Xu-Feng Song, Zhi‐Min Chen*

    Electrophilic Thiocyanation of Tryptamine Derivatives: Divergent Synthesis of SCN-Containing Indole Compounds

    Chem. Asian J. 2022, 17, e202200802 (10.1002/asia.202200802).

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    15. Ai‐Hui Ye, Zi-Hao Li, Tong-Mei Ding, Hua Ke*, Zhi‐Min Chen*

    Phosphoric Acid Catalyzed Electrophilic Thiocyanation of Indoles: Access to SCN-Containing Aryl-Indole Compounds

    Chem. Asian J. 2022, 17,  e202200256, (DOI: 10.1002/asia.202200256).


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    14. Kai Ji, Ka Lu, Jie Huang, Zi-Hao Li, Tong-Mei Ding, Zhi-Min Chen*

    Brønsted Acid-Catalyzed Solvent-Controlled Regioselective Hydrothiolation and Diastereoselective Cascade Cyclization of Dienes

    Chem. Commun., 2021, 57, 12639-12642.


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    13. Kai Ji, Ka Lu, Jie Huang, Zi-Hao Li, Hua Ke*, Zhi-Min Chen*

    Brønsted Acid-Catalyzed Regioselective Hydrothiolation of Dienes: Solvent-Controlled Divergent Synthesis of Sulfides

    Org. Lett. 2021, 23, 8028-8032.


     

    12. Deng Zhu, Hui-Yun Luo, Zhi-Min Chen*

    Selenium-Catalyzed Trifluoromethylsulfinylation/Rearrangement of Allylic and Propargylic Alcohols: Access to Allylic and Allenic Triflones

    Org. Lett. 2021, 23, 1044-1048.


     

    11. Deng Zhu, Tong-Mei Ding, Hui-Yun Luo, Hua Ke, Zhi-Min Chen*

    Divergent Synthesis of Trifluoromethyl Sulfoxides and β-SCF3 Carbonyl Compounds by Tandem Trifluoromethylthiolation/Rearrangement of Allylic and Propargylic Alcohols

    Org. Lett. 2020, 22, 7699-7703.


     

    10. Xu-Feng Song, Tong-Mei Ding, Deng Zhu, Jie Huang, Zhi-Min Chen*

    Lewis-Acid-Mediated Intramolecular Triuoromethylthiolation of Alkenes with Phenols: Access to SCF3Containing Chromane and Dihydrobenzofuran Compounds

    Org. Lett. 2020, 22, 7052-7056.


      

    9. Chao-Chao Xi, Zhi-Min Chen*, Shu-Yu Zhang, Yong-Qiang Tu*.

    Electrophilic Trifluoromethylthiolation/Semipinacol Rearrangement: Preparation of β-SCF3 Carbonyl Compounds with α-Quaternary Carbon Center.

    Org. Lett., 2018, 20, 4227–4230.

     


    8. Kai Ji†, Jie Huang†, Xin-Yu Zhang, Zhi-Min Chen*

    Enantioselective 1,1-Diarylation of Allyl Sulfones Catalyzed by Palladium with a Chiral Phosphoric Acid

    Chem Synth 2022;2:17. http://dx.doi.org/10.20517/cs.2022.27.

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    7. Jie Huang,  Zhi-Min Chen*

    The alkynylative difunctionalization of alkenes

    Chem. Eur. J. 2022, 28, e202201519.

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    6. Jie Huang, Ling-Ling Chen,  Zhi-Min Chen*

    Palladium-Catalyzed Three-Component Cross-Coupling of Conjugated Dienes with Indoles Using Ethynylbenziodazolones as Electrophilic Alkynylating Reagents

    Org. Lett. 2022, 24, 5777-5781.

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    5. Chao Chen, Jun-Chen Kang, Chen Mao, Jia-Wei Dong, Yu-Yang Xie, Tong-Mei Ding, Yong-Qiang Tu, Zhi-Min Chen*, Shu-Yu Zhang*

    Electrochemical Halogenation/Semi-pinacol Rearrangement of Allylic Alcohols Using Inorganic Halide Salt: An Eco-friendly Route to Synthesis of β-halocarbonyls

    Green Chem., 2019, 21, 4014-4019. (Inside front cover)

     


    4. Jun-Chen Kang, Yong-Qiang Tu, Jia-Wei Dong, Chao Chen, Jia Zhou, Tong-Mei Ding, Jian-Tao Zai, Zhi-Min Chen*, Shu-Yu Zhang*.

    Electrochemical semipinacol rearrangements of allylic alcohols: construction of all-carbon quaternary stereocenters.

    Org. Lett., 2019, 21, 2536–2540. (Most downloaded)


     

    3. Yu-Yang Xie, Yun-Peng Wang, Xiao-Jing Zhao, Ai-Fang Wang,  Zhi-Min Chen*, Yong-Qiang Tu*.

    Oxyallyl Cation Promoted Dearomative Semipinacol Rearrangement: Facile Stereodivergent Synthesis of Spiro-indolines with Contiguous Quaternary Centers

    Chem. Commun., 2021, 57, 6632-6635.


    Graphical abstract: Oxyallyl cation promoted dearomative semipinacol rearrangement: a facile stereodivergent synthesis of spiro-indolines with contiguous quaternary centers


    2. Chao-Chao Xi, Xiao-Jing Zhao, Jin-Miao Tian*, Zhi-Min Chen*, Kun Zhang, Fu-Min Zhang, Yong-Qiang Tu*, and Jia-Wei Dong

    Atroposelective Synthesis of Axially Chiral 3-Arylindoles by Copper-Catalyzed Asymmetric Cross-Coupling of Indoles with Quinones and Naphthoquinones

    Org. Lett. 2020, 22, 4995-5000.




    1. Jia‐Wei Dong, Tongmei Ding, Shu‐Yu Zhang*, Zhi‐Min Chen*, Yong‐Qiang Tu*.

    A Facile Approach to Oximes and Ethers by a Tandem NO+‐Initiated Semipinacol Rearrangement and H‐Elimination.

    Angew. Chem. Int. Ed. 2018, 57, 13192-13196.


    Description unavailable


    Prior to SJTU:

     

    8. Zhi-Min Chen†, Jianbo Liu†, Jing-Yao Guo, Maximilian Loch, Ryan Deluca, Matthew S. Sigman* (†equal contribution)

    Palladium-catalyzed enantioselective alkenylation of alkenylbenzene derivatives

    Chem. Sci., 2019, 10, 7246-7250

     

    7. Zhi-Min Chen, Christine S. Nervig, Ryan J. DeLuca, and Matthew S. Sigman*. Palladium-catalyzed enantioselective redox-relay Heck alkynylation of alkenols to access propargylic stereocenters

    Angew. Chem. Int. Ed. 2017, 56, 6651-6654.

     

    6. Zhi-Min Chen, Margaret J. Hilton, and Matthew S. Sigman*.

    Palladium-catalyzed enantioselective redox-relay Heck arylation of 1,1-disubstituted homoallylic alcohols 

    J. Am. Chem. Soc. 2016, 138, 11461-11464.

     

    5. Zhi-Min Chen,† Xiao-Ming Zhang†, and Yong-Qiang Tu* (†equal contribution). Radical aryl migration reactions and synthetic applications

    Chem. Soc. Rev. 2015, 44, 5220-5245.

     

    4. Zhi-Min Chen, Zhen Zhang, Yong-Qiang Tu,* Ming-Hui Xu, Fu-Min Zhang, Chen-Chen Li, and Shao-Hua Wang*.

    A Mn(III)/TEMPO-co-mediated tandem azidation/1,2-carbon migration reaction of allylic silyl ethers 

    Chem. Commun. 2014, 50, 10805-10808.

     

    3. Zhi-Min Chen, Wei Bai, Shao-Hua Wang, Bin-Miao Yang, Yong-Qiang Tu,* and Fu-Min Zhang.

    Copper-catalyzed tandem trifluoromethylation/semipinacol rearrangement of allylic alcohols

    Angew. Chem. Int. Ed. 2013, 52, 9781-9785.

     

    2. Zhi-Min Chen, Bin-Miao Yang, Zhi-Hua Chen, Qing-Wei Zhang, Min Wang, and Yong-Qiang Tu*.

    Organocatalytic asymmetric fluorination/semipinacol rearrangement: An efficient approach to chiral β-fluoroketones 

    Chem. Eur. J. 2012, 18, 12950-12954.

     

    1. Zhi-Min Chen, Qing-Wei Zhang, Zhi-Hua Chen, Hui Li, Yong-Qiang Tu,* Fu-Min Zhang, and Jin-Miao Tian.

    Organocatalytic asymmetric halogenation/semipinacol rearrangement: highly efficient synthesis of chiral α-oxa-quaternary β-haloketones

    J. Am. Chem. Soc. 2011, 133, 8818-8821


  • 人才培养

    2名研究生(罗会云,宋旭峰)获得研究生国家奖学金,4名研究生(罗会云,朱登,黄杰,陈玲玲)获得各类研究生专项奖学金,2名硕士毕业生(宋旭峰,汲凯)获得上海交通大学优秀毕业生。

  • 软件版权登记及专利

    授权中国发明专利4项。

  • 荣誉奖励

    2019 上海市高等学校特聘教授计划(“东方学者”)

    2020 上海交通大学“教书育人奖(集体)”一等奖

  • 教学工作

    本科生:《大学化学》《有机化学实验》

    研究生:《现代有机合成》

  • 人才需求

    欢迎热爱有机合成化学的青年学子加入课题组,共同学习、成长!

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