霍小红长聘(教轨)副教授

电子邮件:huoxiaohong@sjtu.edu.cn
通讯地址:上海市东川路800号上海交通大学化学化工学院B楼529室
个人主页: http://wanbin.sjtu.edu.cn/

  • 教育背景

    2006-2010 河南大学,应用化学,学士

    2010-2012 上海交通大学,有机化学,硕士(导师:张万斌 讲席教授)
    2013-2013  Tohoku University,有机化学,Campus Asia Program(联合导师:Prof. Ilya D. Gridnev and Prof. Masahiro Terada)
    2012-2017 上海交通大学,药学,博士(导师:张万斌 讲席教授  刘燕刚教授)

  • 工作经历

    2017-2019 上海交通大学,博士后(合作导师:张万斌 讲席教授)
    2019-至今 上海交通大学化学化工学院,长聘教轨副教授,博士生导师

  • 研究方向

    1)双金属协同催化体系
    2)重要手性药物的高效不对称合成

    3) 机理研究包括实验与理论研究

  • 科研项目

    主持国家自然科学基金面上项目、青年科学基金项目、上海市“科技创新行动计划”青年科技英才扬帆计划、中国博士后科学基金面上项目一等资助,作为科研骨干参与国家自然科学基金重点、国际(地区)合作和面上项目、上海市科委和教委重大和重点科技攻关项目等多项课题研究。

  • 代表性论文专著

    长期致力于双金属协同催化体系的开发并用于含两个手性中心分子的立体发散性合成研究。迄今,共发表J. Am. Chem. Soc.Angew. Chem.和CCS Chem. 等30余篇。研究论文被Synfacts 、Organic Chemistry Portal 、J. Am. Chem. Soc.Org. Process Res. Dev.Chin. J. Org. Chem.等亮点介绍;并应邀参与了1本英文专著(章)SOS Reference Library: Dual Catalysis in Organic Synthesis 的编写工作。先后获得上海市自然科学奖一等奖(排名第3)、上海市青年科技英才“扬帆计划”、上海交通大学优秀博士学位论文奖、上海交通大学首届学术之星和美国化学会上海分会研究生学术成就奖等荣誉奖励。代表性论文如下:


    30. Xiaohong Huo, Guanlin Li, Xi Wang, and Wanbin Zhang*, Bimetallic Catalysis in Stereodivergent Synthesis. Angew. Chem. Int. Ed202261, accepted. 

     

    29. Youbin Peng, Chongyu Han, Yicong Luo, Guanlin Li, Xiaohong Huo, and Wanbin Zhang*, Nickel/Copper-Cocatalyzed Asymmetric Benzylation of Aldimine Esters for the Enantioselective Synthesis of α-Quaternary Amino Acids. Angew. Chem. Int. Ed202261, e202203448. DOI: 10.1002/anie.202203448

    (Hot Paper; Highlighted by SYNFACTS 202218, 0816)

     

    28. Guanlin Li, Ling Zhao, Yicong Luo, Youbin Peng, Kai Xu, Xiaohong Huo,* and Wanbin Zhang*, Stereodivergent Desymmetrization of Simple Dicarboxylates via Branch-Selective Pd/Cu Catalyzed Allylic Substitution. Chem. Eur. J. 2022, 28(24), e202200273. DOI: 10.1002/chem.202200273

    (Hot Paper)

     

    27. Jiacheng Zhang,§ Xiaohong Huo,§ Junzhe Xiao,§ Ling Zhao, Shengming Ma*, and Wanbin Zhang*, Enantio- and Diastereodivergent Construction of 1,3-Nonadjacent Stereocenters Bearing Axial and Central Chirality through Synergistic Pd/Cu Catalysis. J. Am. Chem. Soc. 2021, 143(32), 12622-12632. DOI: 10.1021/jacs.1c05087

    (§co-first author)

     

    26. Youbin Peng,§ Xiaohong Huo § Yicong Luo, Liang Wu, and Wanbin Zhang*, Enantio- and Diastereodivergent Synthesis of Spirocycles through Dual-Metal-Catalyzed [3+2] Annulation of 2-Vinyloxiranes with Nucleophilic Dipoles. Angew. Chem. Int. Ed. 202160(47), 24941-24949DOI: 10.1002/anie.202111842

    (Hot Paper; Highlighted by SYNFACTS 202117, 1352; §co-first author)


    25. Xiaohong Huo, Ling Zhao, Yicong Luo, Yue Wu, Yuwen Sun, Guanlin Li, Tatiana Gridneva, Jiacheng Zhang, Yong Ye, and Wanbin Zhang*, Stereodivergent Pd/Cu Catalysis for Asymmetric Desymmetric Alkylation of Allylic Geminal Dicarboxylates. CCS Chem. 2021, 3, 1933-1944.
    DOI: 10.31635/ccschem.021.202101044

     

    24. Tianhong Wang, Youbin Peng, Guanlin Li, Yicong Luo, Yong Ye, Xiaohong Huo*, and Wanbin Zhang*, Synergistic Ir/Cu Catalysis for Asymmetric Allylic Alkylation of Oxindoles: Enantio- and Diastereoselective Construction of Quaternary and Tertiary Stereocenters. Chem. Eur. J. 2021, 27(40), 10255-10260. DOI: 10.1002/chem.202101267

    (Very Important Paper)

     

    23. Ling Zhao, Guanlin Li, Rui He, Penglin Liu, Feijun Wang, Xiaohong Huo*, Min Zhao*, and Wanbin Zhang*, Stereodivergent Pd/Cu Catalysis: Asymmetric Alkylation of Racemic Symmetrical 1,3-Diphenyl Allyl Acetates. Org. Biomol. Chem. 2021, 19(9), 1955-1959. DOI: 10.1039/d0ob02499f

    (Invited Paper for Hybrid Catalysis; Highlighted by SYNFACTS 2021, 17, 586)

     

    22. Mo Wang, Lu Zhang, Xiaohong Huo, Zhenfeng Zhang, and Wanbin Zhang*, Chemical Synthesis of the anti-COVID-19 Drug Remdesivir. Current Protocols 20211, e303. DOI: 10.1002/cpz1.303

    (Invited Paper also for Biologically Active NucleosidesNucleoside Prodrugs and Delivery Strategies)


    21. Junzhe Xiao, Haibo Xu, Xiaohong Huo, Wanbin Zhang*, Shengming Ma*, One Stone Two Birds-Enantioselective Bimetalic Catalysis for α-Amino Acid Derivatives with An Allene Unit. Chin. J. Chem. 202139(7), 1958-1964. DOI: 10.1002/cjoc.202100002


    20. Rui He,§ Xiaohong Huo,§ Ling Zhao, Feijun Wang, Liyin Jiang, Jian Liao*, and Wanbin Zhang*, Stereodivergent Pd/Cu Catalysis for the Dynamic Kinetic Asymmetric Transformation of Racemic Unsymmetrical 1,3-Disubstituted Allyl Acetates. J. Am. Chem. Soc. 2020142(18), 8097-8103. DOI: 10.1021/jacs.0c02150
    (Highlighted by 有机化学 202040, 2161; §co-first author)

     

    19. Mo Wang,§ Lu Zhang,§ Xiaohong Huo,§ Zhenfeng Zhang,§ Qianjia Yuan, Panpan Li, Jianzhong Chen, Yashi Zou, Zhengxing Wu, and Wanbin Zhang*, Catalytic Asymmetric Synthesis of the anti-COVID-19 Drug Remdesivir. Angew. Chem. Int. Ed. 2020, 59(47), 20814-20819. DOI: 10.1002/anie.202011527
    (Highlighted by SYNFACTS 2020, 16, 1350; Very Important Paper; Frontispiece; 入选第二届上海交通大学十大科技进展; §co-first author)

     

    18. Guanlin Li,§ Xiaohong Huo,§ Xieyang Jiang, and Wanbin Zhang*, Asymmetric Synthesis of Allylic Compounds via Hydrofunctionalisation and Difunctionalisation of Dienes, Allenes, and Alkynes. Chem. Soc. Rev. 2020, 49(7), 2060-2118. DOI: 10.1039/c9cs00400a

    (Inside Front Cover; ESI Highly Cited Paper; §co-first author)


    17. 霍小红, 张万斌*, Pd/Cu双金属协同催化用于立体发散性构建联烯轴手性和中心手性. 有机化学 202141(8), 3337-3338. DOI: 10.6023/cjoc202100058
    (Invited Highlight)

     

    16. Yue Wu, Xiaohong Huo*, and Wanbin Zhang*, Synergistic Pd/Cu Catalysis in Organic Synthesis. Chem. Eur. J. 2020, 26(22), 4895-4916. DOI: 10.1002/chem.201904495

    (Invited Review; Frontispiece)

     

    15. Xiaohong Huo, Rui He, and Wanbin Zhang*, Iridium/Zinc and Iridium/Copper Dual Catalysis. In Science of Synthesis: Dual Catalysis in Organic Synthesis, Molander, G. A., Ed.; Thieme: Stuttgart, (2019); Vol. 1, p 83-106. DOI: 10.1021/jacs.6b06156
    (Invited Book Chapter)


    14. Jiacheng Zhang,§ Xiaohong Huo,§ Bowen Li, Zhouli Chen, Yashi Zou, Zhenliang Sun*, and Wanbin Zhang*, Enantioselective and Diastereodivergent Access to α-Substituted α-Amino Acids via Dual Iridium and Copper Catalysis. Adv. Synth. Catal. 2019, 361(5), 1130-1139. DOI: 10.1002/adsc.201801148

    (§co-first author)

     

    13. Xiaohong Huo, Jiacheng Zhang, Jingke Fu, Rui He, and Wanbin Zhang*, Ir/Cu Dual Catalysis: Enantio- and Diastereodivergent Access to α,α-Disubstituted α-Amino Acids Bearing Vicinal Stereocenters. J. Am. Chem. Soc. 2018140(6), 2080-2084. DOI: 10.1021/jacs.8b00187
    (Highlighted by Organic Chemistry Portal; ESI Highly Cited Paper)

     

    12. Xiaohong Huo,§ Jingke Fu,§ Xiaobo He, Jianzhong Chen, Fang Xie, and Wanbin Zhang*, Pd/Cu Dual Catalysis: Highly Enantioselective Access to α-Substituted α-Amino Acids and α-Amino Amides. Chem. Commun. 201854(6), 599-602. DOI: 10.1039/c7cc08732b
    (Highlighted by SYNFACTS 201814, 0264; SYNFACTS 201814, 0393; §co-first author)


    11. Penglin Liu,§ Xiaohong Huo,§ Bowen Li, Rui He, Jiacheng Zhang, Tianhong Wang, Fang Xie*, and Wanbin Zhang*, Stereoselective Allylic Alkylation of 1‑Pyrroline-5-carboxylic Esters via a Pd/Cu Dual Catalysis. Org. Lett. 2018, 20(20), 6564-6568. DOI: 10.1021/acs.orglett.8b02902
    (Highlighted by SYNFACTS 2018, 14, 1260; §co-first author)

     

    10. Rui He, Shanchao Wu, Haoming Tang, Xiaohong Huo, Zhenliang Sun*, and Wanbin Zhang*, Iridium-Catalyzed Enantioselective and Diastereoselective Allylation of Dioxindoles: A One-Step Synthesis of 3-Allyl-3-hydroxyoxindoles. Org. Lett. 2018, 20(19), 6183-6187. DOI: 10.1021/acs.orglett.8b02655
    (Highlighted by SYNFACTS 2018, 14, 1259)

     

    9. Xiaohong Huo, Rui He, Jingke Fu, Jiacheng Zhang, Guoqiang Yang, and Wanbin Zhang*, Stereoselective and Site-Specific Allylic Alkylation of Amino Acids and Small Peptides via a Pd/Cu Dual Catalysis. J. Am. Chem. Soc. 2017139(29), 9819-9822. DOI: 10.1021/jacs.7b05460

    (Highlighted by SYNFACTS 201713, 1049 and 有机化学 201737, 2454)

     

    8. Jingke Fu, Xiaohong Huo, Bowen Li, and Wanbin Zhang*, Cooperative Bimetallic Catalysis in Asymmetric Allylic Substitution. Org. Biomol. Chem. 2017, 15(46), 9747-9759.

    DOI: 10.1039/c7ob02476b

     

    7. Rui He, Penglin Liu, Xiaohong Huo, and Wanbin Zhang*, Ir/Zn Dual Catalysis: Enantioselective and Diastereodivergent α-Allylation of Unprotected α-Hydroxy Indanones. Org. Lett. 2017, 19(20), 5513-5516. DOI: 10.1021/acs.orglett.7b02577
    (Highlighted by SYNFACTS 2017, 13, 1292)


    6.Jiangyan Jing, Xiaohong Huo, Jiefeng Shen*, Jingke Fu, Qinghua Meng*, and Wanbin Zhang*, Direct Use of Allylic Alcohols and Allylic Amines in Palladium-Catalyzed Allylic Amination. Chem. Commun. 2017, 53(37), 5151-5154. DOI: 10.1039/c7cc01069a

     

    5. Xiaohong Huo,§ Rui He,§ Xiao Zhang, and Wanbin Zhang*, An Ir/Zn Dual Catalysis for Enantio- and Diastereodivergent α-Allylation of α-Hydroxyketones. J. Am. Chem. Soc. 2016, 138(35), 11093-11096. DOI: 10.1021/jacs.6b06156
    (Highlighted by SYNFACTS 2016, 12, 1153 and selected as Front Cover and Synfact of the month; Highlighted by Org. Process. Res. Dev. 2016, 20, 1691; §co-first author)

     

    4. 汤淏溟, 霍小红, 孟庆华*, 张万斌*, 钯催化的烯丙位C-H键官能团化: 新催化体系的发展. 化学学报 2016, 74(3), 219-233. DOI: 10.6023/A16020078
    (入选《化学学报》"2018年度最具影响力论文奖")

     

    3. Xiaohong Huo, Guoqiang Yang, Delong Liu, Yangang Liu, Ilya D. Gridnev*, and Wanbin Zhang*, Palladium-Catalyzed Allylic Alkylation of Simple Ketones with Allylic Alcohols and Its Mechanistic Study. Angew. Chem. Int. Ed. 2014, 53(26), 6776-6780. DOI: 10.1002/anie.201403410

     

    2. Xiaohong Huo, Mao Quan, Guoqiang Yang, Xiaohu Zhao, Delong Liu*, Yangang Liu, and Wanbin Zhang*, Hydrogen-Bond-Activated Palladium-Catalyzed Allylic Alkylation via Allylic Alkyl Ethers: Challenging Leaving Groups. Org. Lett. 2014, 16(6), 1570-1573. DOI: 10.1021/ol5000988

     

    1. 余坤矫, 张振锋*, 霍小红, 王兴广, 刘德龙, 张万斌*, D-(R)-酪氨酸的不对称催化氢化合成及其在药物合成中的应用. 有机化学 2013, 33(9), 1932-1938. DOI: 10.6023/cjoc201305051
    (Front Cover)


  • 软件版权登记及专利

    1. 发明人: 张万斌、何睿、张晓、霍小红;
    发明名称: 3-取代的3-乙烯基-2-羟基-1-芳基丙酮及其合成方法;
    申请日: 2016.08.16; 授权公告日: 2020.09.15;
    授权公告号: CN106316813B;
    授权专利号:
    ZL 2016 1 0674646.7

    2. 发明人: 张万斌、王沫、张露、霍小红、张振锋、袁乾家、陈建中;
    发明名称: 一种磷手性核苷衍生物的不对称催化合成方法及催化剂;
    专利申请日: 2020.6.3; 授权公告日: 2021.12.7;
    专利号: CN202010495819.5

    3. 发明人: 张万斌、陈建中、张露、袁乾家、霍小红、张振锋;
    发明名称: 一种不对称催化无保护基核苷合成瑞德西韦的方法;
    专利申请日: 2020.6.3; 授权公告日: 2021.12.7;
    专利号: CN202010495820.8

  • 荣誉奖励

    1)2014年上海交通大学三好学生

    2)2014年博士生国家奖学金

    3)2016年上海交通大学药学院“科技创新先进个人”

    4)2016年美国化学会上海分会研究生学术成就奖二等奖

    5)2016年上海交通大学第一届学术之星(共10名)

    6)2018年上海交通大学博士后考核优秀

    7)2018年上海交通大学优秀博士学位论文奖(共13名,作为唯一博士毕业生代表发言)

    8)2019年上海市“科技创新行动计划”青年科技英才扬帆计划
    9)2020年上海市自然科学奖一等奖(第三完成人)

    10)2022年上海交通大学第二届“十大科技进展”

    11)第十七届“挑战杯”特等奖指导专家

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