王平长聘(教轨)副教授

办公电话:021-54743264
电子邮件:wangp1@sjtu.edu.cn
通讯地址:上海市东川路800号 化学B楼228

  • 教育背景

    1996-2000:  南京大学化学系,学士
    2000-2005:  中国科学院上海有机化学研究所,博士,导师:俞飚 研究员

  • 工作经历

    2005-2008:  美国伯纳姆医学研究所,博士后,导师: Peter H.Seegerber 教授
    2008-2013:  纪念斯隆凯特琳癌症中心,博士后、资深研究科学家,导师: Samuel J.Danishefsky 教授
    2013-2016.2:  波士顿WARP DRIVE BIO 生物技术公司,研究科学家
    2016.3- :  上海交通大学化学化工学院,特别研究员

  • 研究方向

    1)化学合成具有重要生理活性的糖蛋白、糖肽
    2)糖类分子合成及其方法学研究
    3)多肽合成方法学研究

  • 代表性论文专著

    1.       Wang, S.; Zhou, Q.; Zhang, X.; Wang, P., et. al. Quinoline-based photolabile protection strategy facilitates efficient protein assembly. J. Am. Chem. Soc. Just accept.

    2.       Zhao, J.; Wang, P., et. al. Revealing functional significance of interleukin-2 glycoproteoforms enabled by expressed serine ligation. Just accept.

    3.       Chen, X.; Wang, P., Facile Access to C-Glycosyl Amino Acids and Peptides via Ni-Catalyzed Reductive Hydroglycosylation of Alkynes. Chin. J. Org. Chem. 2021, 41, 4517-4518.

    4.       Luo, X.; Wang, P., Ynonylation of Acyl Radicals by Electroinduced Homolysis of 4‑Acyl1,4-dihydropyridine. Org. Lett. 2021, 23, 4960-4965.

    5.       Wang, S.; Zhou, Q.; Zhang, X.; Wang, P., Site-Selective Itaconation of Complex Peptides by Photoredox Catalysis. Angew. Chem. Int. Ed. DOI: 10.1002/anie.202111388.

    6.       Wang, S.; Zhou, Q.; Chen, X.; Luo, R.-H.; Li, Y.; Liu, X.; Yang, L.-M.; Zheng, Y.-T.; Wang, P., Modification of N-Terminal α-Amine of Proteins via Biomimetic ortho-quinone-mediated Oxidation. Nat. Commun. 2021, 12:2257.

    7.       Ye, F.; Zhao, J.; Xu, P.; Liu, X.; Yu, J.; Shangguan, W.; Liu, J.; Luo, X.; Li, C.; Ying, T.; Wang, J.; Yu, B.; Wang, P., Synthetic Homogeneous Glycoforms of the SARS-CoV-2 Spike Receptor-Binding Domain Reveals Different Binding Profiles of Monoclonal Antibodies. Angew. Chem. Int. Ed. 2021, 60, 12904-12910.

    8.       Li, Y.; Liu, J.; Zhou, Q.; Zhao, J.; Wang, P., The preparation of peptide selenoesters from their corresponding acyl hydrazides. Chin. J. Chem. 2021, 39, 1861-1866.

    9.       Yin, H.;  Zheng, M.;  Chen, H.;  Wang, S.;  Zhou, Q.;  Zhang, Q.; Wang, P., Stereoselective and Divergent Construction of β-Thiolated/Selenolated Amino Acids via Photoredox-Catalyzed Asymmetric Giese Reaction. J. Am. Chem. Soc. 2020, 142, 14201-14209.

    10.     Chen, X.;  Catalyst-Free Decarboxylation of Carboxylic Acids and Deoxygenation of Alcohols by Electro-Induced Radical Formation. Chem. Eur. J. 2020, 26, 3226- 3230.

    11.     Chen, X.;  Luo, X.;  Wang, K.;  Liang, F.; Wang, P., Late-Stage Alkylation of N-Containing Heteroarenes Enabled by Homolysis of Alkyl-1,4-dihydropyridines under Blue LED Irradiation. Synlett 2021, 32, 733–737.

    12.     Lu, D.;  Wang, S.;  Yin, H.;  Chu, F.;  Wei, Q.; Wang, P., Rapid Assembly of Oligosaccharides by Using a Hydrophobic Tag-Assisted Liquid-Phase Method. Synlett 2020, 31, 1163-1166.

    13.     Lu, D.;  Yin, H.;  Wang, S.;  Tang, F.;  Huang, W.; Wang, P., Chemical Synthesis of the Homogeneous Granulocyte-Macrophage Colony-Stimulating Factor Through Se-Auxiliary-Mediated Ligation. J. Org. Chem. 2020, 85, 1652-1660.

    14.     Chen, X.;  Ye, F.;  Luo, X.;  Liu, X.;  Zhao, J.;  Wang, S.;  Zhou, Q.;  Chen, G.; Wang, P., Histidine-Specific Peptide Modification via Visible-Light-Promoted C–H Alkylation. J. Am. Chem. Soc. 2019, 141, 18230-18237.

    15.     Liu, X.;  Liu, J.;  Wu, Z.;  Chen, L.;  Wang, S.; Wang, P., Photo-cleavable purification/protection handle assisted synthesis of giant modified proteins with tandem repeats. Chem. Sci. 2019, 10, 8694-8700.

    16.     Wang, K.;  Chen, X.;  Peng, X.;  Wang, P.; Liang, F., A highly selective H/D exchange reaction of 1,4-dihydropyridines. Org. Biomol. Chem. 2019, 17, 3845-3852.

    17.     Wang, S.;  Thopate, Y. A.;  Zhou, Q.; Wang, P., Chemical Protein Synthesis by Native Chemical Ligation and Variations Thereof. Chin. J. Chem. 2019, 37, 1181-1193.

    18.     Ye, J.;  Xia, H.;  Sun, N.;  Liu, C.-C.;  Sheng, A.;  Chi, L.;  Liu, X.-W.;  Gu, G.;  Wang, S.-Q.;  Zhao, J.;  Wang, P.;  Xiao, M.;  Wang, F.; Cao, H., Reprogramming the enzymatic assembly line for site-specific fucosylation. Nat. Catal. 2019, 2, 514-522.

    19.     Yin, H.;  Lu, D.;  Wang, S.; Wang, P., Development of Powerful Auxiliary-Mediated Ligation To Facilitate Rapid Protein Assembly. Org. Lett. 2019, 21, 5138-5142.

    20.     Luo, H.;  Yin, H.;  Tang, C.;  Wang, P.; Liang, F., Synthesis of cyclic peptide reniochalistatin E and conformational isomers. Chin. Chem. Lett. 2018, 29, 1143-1146.

     

    Before 2018

    21.     Wang, P.; Dong, S.; Shieh, J.-H.; Peguero, E.; Hendrickson, R.; Moore, M. A. S.; Danishefsky, S. J., Erythropoietin Derived by Chemical Synthesis. Science 2013, 342 (6164), 1357-1360.

    22.     Wilson, R. M.; Dong, S.; Wang, P.; Danishefsky, S. J., The Winding Pathway to Erythropoietin Along the Chemistry–Biology Frontier: A Success At Last. Angew. Chem. Int. Ed. 2013, 52 (30), 7646-7665.

    23.     Yang, X.; Wang, P.; Yu, B., Tackling the Challenges in the Total Synthesis of Landomycin A. Chem. Rec. 2013, 13 (1), 70-84.

    24.     Wang, P.; Dong, S.; Brailsford, J. A.; Iyer, K.; Townsend, S. D.; Zhang, Q.; Hendrickson, R. C.; Shieh, J.; Moore, M. A. S.; Danishefsky, S. J., At Last: Erythropoietin as a Single Glycoform. Angew. Chem. Int. Ed. 2012, 51 (46), 11576-11584.

    25.     Wang, P.; Aussedat, B.; Vohra, Y.; Danishefsky, S. J., An Advance in the Chemical Synthesis of Homogeneous N-Linked Glycopolypeptides by Convergent Aspartylation. Angew. Chem. Int. Ed. 2012, 51 (46), 11571-11575.

    26.     Wilson, R. M.; Stockdill, J. L.; Wu, X.; Li, X.; Vadola, P. A.; Park, P. K.; Wang, P.; Danishefsky, S. J., A Fascinating Journey into History: Exploration of the World of Isonitriles En Route to Complex Amides. Angew. Chem. Int. Ed. 2012, 51 (12), 2834-2848.

    27.     Shibata, T. K.; Matsumura, F.; Wang, P.; Yu, S.; Chou, C.-C.; Khoo, K.-H.; Kitayama, K.; Akama, T. O.; Sugihara, K.; Kanayama, N.; Kojima-Aikawa, K.; Seeberger, P. H.; Fukuda, M.; Suzuki, A.; Aoki, D.; Fukuda, M. N., Identification of Mono- and Disulfated N-Acetyl-lactosaminyl Oligosaccharide Structures as Epitopes Specifically Recognized by Humanized Monoclonal Antibody HMOCC-1 Raised against Ovarian Cancer. J. Biol. Chem. 2012, 287 (9), 6592-6602.

    28.     Wang, P.; Li, X.; Zhu, J.; Chen, J.; Yuan, Y.; Wu, X.; Danishefsky, S. J., Encouraging Progress in the ω-Aspartylation of Complex Oligosaccharides as a General Route to β-N-Linked Glycopolypeptides. J. Am. Chem. Soc. 2011, 133 (5), 1597-1602.

    29.     Wang, P.; Danishefsky, S. J., Promising General Solution to the Problem of Ligating Peptides and Glycopeptides. J. Am. Chem. Soc. 2010, 132 (47), 17045-17051.

    30.     Wu, X.; Stockdill, J. L.; Wang, P.; Danishefsky, S. J., Total Synthesis of Cyclosporine: Access to N-Methylated Peptides via Isonitrile Coupling Reactions. J. Am. Chem. Soc. 2010, 132 (12), 4098-4100.

    31.     Chen, J.; Wang, P.; Zhu, J.; Wan, Q.; Danishefsky, S. J., A program for ligation at threonine sites: application to the controlled total synthesis of glycopeptides. Tetrahedron 2010, 66 (13), 2277-2283.

    32.     Wang, P.; Zhu, J.; Yuan, Y.; Danishefsky, S. J., Total Synthesis of the 2,6-Sialylated Immunoglobulin G Glycopeptide Fragment in Homogeneous Form. J. Am. Chem. Soc. 2009, 131 (46), 16669-16671.

    33.     Lee, H.; Wang, P.; Hoshino, H.; Ito, Y.; Kobayashi, M.; Nakayama, J.; Seeberger, P. H.; Fukuda, M., α1,4GlcNAc-capped mucin-type O-glycan inhibits cholesterol α-glucosyltransferase from Helicobacter pylori and suppresses H. pylori growth. Glycobiology 2008, 18 (7), 549-558.

    34.     Wang, P.; Lee, H.; Fukuda, M.; Seeberger, P. H., One-pot synthesis of a pentasaccharide with antibiotic activity against Helicobacter pylori. Chem. Commun. 2007, 38 (19), 1963-1965.

    35.     Lee, H.; Kobayashi, M.; Wang, P.; Nakayama, J.; Seeberger, P. H.; Fukuda, M., Expression cloning of cholesterol α-glucosyltransferase, a unique enzyme that can be inhibited by natural antibiotic gastric mucin O-glycans, from Helicobacter pylori. Biochem. Biophys. Res. Commun. 2006, 349 (4), 1235-1241.

    36.     Wang, P.; Zhang, Z.; Yu, B., Total Synthesis of CRM646-A and -B, Two Fungal Glucuronides with Potent Heparinase Inhibition Activities. J. Org. Chem. 2005, 70 (22), 8884-8889.

    37.     Yu, B.; Wang, P., Efficient Synthesis of the Hexasaccharide Fragment of Landomycin A:  Using Phenyl 2,3-O-Thionocarbonyl-1-thioglycosides as 2-Deoxy-β-glycoside Precursors. Org. Lett. 2002, 4 (11), 1919-1922.

     

    Patent

    38.     Jeffrey V. Ravetch, Andrew Pincetic, Ping Wang, Samuel J. Danishefsky, Human DC-SIGN binding peptides derived from IgG1 Fc fragment. PCT Int. Appl. 2013, WO 2013095973 A1 20130627.

    39.     Samuel J. Danishefsky, Ping Wang, Suwei Dong, Malcolm A. Moore, Jaehung Shieh, John A. Brailsford,. Homogenous and fully glycosylated human erythropoietin. PCT Int. Appl. (2013), WO 2013166053 A2 20131107. 

     

     

     


地址:上海市东川路800号 200240
电话:021-54742893
E-mail:sjtuscce@sjtu.edu.cn

官方微信平台

Copyright 2020 沪交ICP备2010917 上海交通大学化学化工学院