王平研究员

办公电话:021-54743264
电子邮件:wangp1@sjtu.edu.cn
通讯地址:上海市东川路800号 化学B楼228

  • 教育背景

    2000年本科毕业于南京大学,2005年毕业于上海有机化学研究所,获博士学位(导师:俞飚院士)。曾获得国家杰出青年基金、国家海外高层次青年人才等荣誉。


  • 工作经历

    2005-2008:  美国伯纳姆医学研究所,博士后
    2008-2013:  纪念斯隆凯特琳癌症中心,博士后、资深研究科学家
    2013-2016.4:  波士顿WARP DRIVE BIO 生物技术公司,研究科学家
    2016.5- :  上海交通大学化学化工学院,研究员

  • 研究方向

    1)化学合成具有重要生理活性的糖蛋白、糖肽
    2)糖类分子合成及其方法学研究
    3)多肽合成方法学研究

  • 科研项目

    国家杰出青年科学基金、国家自然科学基金重大研究计划集成、培育项目、国家自然科学基金面上项目

  • 代表性论文专著

    1.       Liu, X. L.; Gao, Z.; Ye, F.; Zhao, J.; Huang, P.; Wang, P. Encouraging Solution to the Problem of Synthesizing Protein α-Thioester. Chin. J. Chem. 2024, 42, 1114—1120 (Cover Paper).

    2.       Ye, F.; Li, C.; Liu, F. L.; Liu, X. L.; Xu, P.; Luo, R. H.; Song, W. P.; Zheng, Y. T.; Ying, T. L.; Yu, B.; Wang, P. Semisynthesis of homogeneous spike RBD glycoforms from SARS-CoV-2 for profiling the correlations between glycan composition and function. Natl. Sci. Rev. 2024, DOI: 10.1093/nsr/nwae030.

    3.       Zhao, J.; Liu, X. L.; Liu, J. L.; Ye, F. R.; Wei, B. C.; Deng, M. G.; Li, T. H.; Huang, P.; Wang, P. Chemical synthesis creates single glycoforms of the ectodomain of herpes simplex virus-1 glycoprotein D. J. Am. Chem. Soc. 2024, 146, 4, 2615–2623 (Cover Paper).

    4.       Zhao, J.; Ye, F.; Huang, P.; Wang, P., Recent advances in chemical synthesis of O-linked glycopeptides and glycoproteins: An advanced synthetic tool for exploring the biological realm. Curr Opin Chem Biol 2023, 77:102405.

    5.       Shangguan, H.; Huang, P.; Dai, Z,; Wang, P., Synthesis and Application of β-Thiolated Amino Acids. Chin. J. Org. Chem. 2023, 43, 3089-3097.

    6.       Zhao, J.; Wang, P., et. al. Semi-synthesis of interleukin-1a via expressed threonine ligation and native chemical ligation-desulfurization. Tetrahedron Letters 104 (2022) 154024.

    7.       Zheng, M.; Yin, H.; Wang S.; Wang, P., Stereoselective Synthesis of β-thiolated Aryl Amino Acids. Synthesis 2022. doi: 10.1055/a-1874-4829.

    8.       Chen, X.;  Luo, X.; Wang, P., Electrochemical-induced Radical Allylation via the Fragmentation of Alkyl 1,4-Dihydropyridines. Tetrahedron Letters 2022, doi.org/10.1016/j.tetlet.2022.153646.

    9.       Luo, X.; Feng, Q.; Wang, P., Radical Addition of Hydroxy Quinazolines and Alkylation of Quinones via the Electro-induced Homolysis of 4-Alkyl-1,4-dihydropyridines. Synthesis. 2022, DOI: 10.1055/a-1737-2765.

    10.     Wang, S.; Zhou, Q.; Li, Y.; Wei, B.; Liu, X.; Zhao, J.; Ye, F.; Zhou, Z.; Ding, B.; Wang, P. Quinoline-based photolabile protection strategy facilitates efficient protein assembly. J. Am. Chem. Soc. 2022, 144, 1232-1242.

    11.     Zhao, J.; Wang, P., et. al. Revealing functional significance of interleukin-2 glycoproteoforms enabled by expressed serine ligation. Chin. J. Chem. 2022, 40, 787-793.

    12.     Wang, S.; Zhou, Q.; Zhang, X.; Wang, P., Site-Selective Itaconation of Complex Peptides by Photoredox Catalysis. Angew. Chem. Int. Ed. 2022, 61, e202111388.

    13.     Chen, X.; Wang, P., Facile Access to C-Glycosyl Amino Acids and Peptides via Ni-Catalyzed Reductive Hydroglycosylation of Alkynes. Chin. J. Org. Chem. 2021, 41, 4517-4518.

    14.     Luo, X.; Wang, P., Ynonylation of Acyl Radicals by Electroinduced Homolysis of 4‑Acyl1,4-dihydropyridine. Org. Lett. 2021, 23, 4960-4965.

    15.     Wang, S.; Zhou, Q.; Chen, X.; Luo, R.-H.; Li, Y.; Liu, X.; Yang, L.-M.; Zheng, Y.-T.; Wang, P., Modification of N-Terminal α-Amine of Proteins via Biomimetic ortho-quinone-mediated Oxidation. Nat. Commun. 2021, 12:2257.

    16.     Ye, F.; Zhao, J.; Xu, P.; Liu, X.; Yu, J.; Shangguan, W.; Liu, J.; Luo, X.; Li, C.; Ying, T.; Wang, J.; Yu, B.; Wang, P., Synthetic Homogeneous Glycoforms of the SARS-CoV-2 Spike Receptor-Binding Domain Reveals Different Binding Profiles of Monoclonal Antibodies. Angew. Chem. Int. Ed. 2021, 60, 12904-12910 (Cover Paper).

    17.     Li, Y.; Liu, J.; Zhou, Q.; Zhao, J.; Wang, P., The preparation of peptide selenoesters from their corresponding acyl hydrazides. Chin. J. Chem. 2021, 39, 1861-1866.

    18.     Chen, X.;  Luo, X.;  Wang, K.;  Liang, F.; Wang, P., Late-Stage Alkylation of N-Containing Heteroarenes Enabled by Homolysis of Alkyl-1,4-dihydropyridines under Blue LED Irradiation. Synlett 2021, 32, 733–737.

    19.     Yin, H.;  Zheng, M.;  Chen, H.;  Wang, S.;  Zhou, Q.;  Zhang, Q.; Wang, P., Stereoselective and Divergent Construction of β-Thiolated/Selenolated Amino Acids via Photoredox-Catalyzed Asymmetric Giese Reaction. J. Am. Chem. Soc. 2020, 142, 14201-14209.

    20.     Chen, X.; Luo, X.; Peng, X.; Guo, J.; Zai, J.; Wang, P., Catalyst-Free Decarboxylation of Carboxylic Acids and Deoxygenation of Alcohols by Electro-Induced Radical Formation. Chem. Eur. J. 2020, 26, 3226- 3230.

    21.     Lu, D.;  Wang, S.;  Yin, H.;  Chu, F.;  Wei, Q.; Wang, P., Rapid Assembly of Oligosaccharides by Using a Hydrophobic Tag-Assisted Liquid-Phase Method. Synlett 2020, 31, 1163-1166.

    22.     Lu, D.;  Yin, H.;  Wang, S.;  Tang, F.;  Huang, W.; Wang, P., Chemical Synthesis of the Homogeneous Granulocyte-Macrophage Colony-Stimulating Factor Through Se-Auxiliary-Mediated Ligation. J. Org. Chem. 2020, 85, 1652-1660.

    23.     Chen, X.;  Ye, F.;  Luo, X.;  Liu, X.;  Zhao, J.;  Wang, S.;  Zhou, Q.;  Chen, G.; Wang, P., Histidine-Specific Peptide Modification via Visible-Light-Promoted C–H Alkylation. J. Am. Chem. Soc. 2019, 141, 18230-18237.

    24.     Liu, X.;  Liu, J.;  Wu, Z.;  Chen, L.;  Wang, S.; Wang, P., Photo-cleavable purification/protection handle assisted synthesis of giant modified proteins with tandem repeats. Chem. Sci. 2019, 10, 8694-8700.

    25.     Wang, K.;  Chen, X.;  Peng, X.;  Wang, P.; Liang, F., A highly selective H/D exchange reaction of 1,4-dihydropyridines. Org. Biomol. Chem. 2019, 17, 3845-3852.

    26.     Wang, S.;  Thopate, Y. A.;  Zhou, Q.; Wang, P., Chemical Protein Synthesis by Native Chemical Ligation and Variations Thereof. Chin. J. Chem. 2019, 37, 1181-1193.

    27.     Ye, J.;  Xia, H.;  Sun, N.;  Liu, C.-C.;  Sheng, A.;  Chi, L.;  Liu, X.-W.;  Gu, G.;  Wang, S.-Q.;  Zhao, J.;  Wang, P.;  Xiao, M.;  Wang, F.; Cao, H., Reprogramming the enzymatic assembly line for site-specific fucosylation. Nat. Catal. 2019, 2, 514-522.

    28.     Yin, H.;  Lu, D.;  Wang, S.; Wang, P., Development of Powerful Auxiliary-Mediated Ligation To Facilitate Rapid Protein Assembly. Org. Lett. 2019, 21, 5138-5142.

    29.     Luo, H.;  Yin, H.;  Tang, C.;  Wang, P.; Liang, F., Synthesis of cyclic peptide reniochalistatin E and conformational isomers. Chin. Chem. Lett. 2018, 29, 1143-1146.

     

    Before 2018

    30.     Wang, P.; Dong, S.; Shieh, J.-H.; Peguero, E.; Hendrickson, R.; Moore, M. A. S.; Danishefsky, S. J., Erythropoietin Derived by Chemical Synthesis. Science 2013, 342 (6164), 1357-1360.

    31.     Wilson, R. M.; Dong, S.; Wang, P.; Danishefsky, S. J., The Winding Pathway to Erythropoietin Along the Chemistry–Biology Frontier: A Success At Last. Angew. Chem. Int. Ed. 2013, 52 (30), 7646-7665.

    32.     Yang, X.; Wang, P.; Yu, B., Tackling the Challenges in the Total Synthesis of Landomycin A. Chem. Rec. 2013, 13 (1), 70-84.

    33.     Wang, P.; Dong, S.; Brailsford, J. A.; Iyer, K.; Townsend, S. D.; Zhang, Q.; Hendrickson, R. C.; Shieh, J.; Moore, M. A. S.; Danishefsky, S. J., At Last: Erythropoietin as a Single Glycoform. Angew. Chem. Int. Ed. 2012, 51 (46), 11576-11584.

    34.     Wang, P.; Aussedat, B.; Vohra, Y.; Danishefsky, S. J., An Advance in the Chemical Synthesis of Homogeneous N-Linked Glycopolypeptides by Convergent Aspartylation. Angew. Chem. Int. Ed. 2012, 51 (46), 11571-11575.

    35.     Wilson, R. M.; Stockdill, J. L.; Wu, X.; Li, X.; Vadola, P. A.; Park, P. K.; Wang, P.; Danishefsky, S. J., A Fascinating Journey into History: Exploration of the World of Isonitriles En Route to Complex Amides. Angew. Chem. Int. Ed. 2012, 51 (12), 2834-2848.

    36.     Shibata, T. K.; Matsumura, F.; Wang, P.; Yu, S.; Chou, C.-C.; Khoo, K.-H.; Kitayama, K.; Akama, T. O.; Sugihara, K.; Kanayama, N.; Kojima-Aikawa, K.; Seeberger, P. H.; Fukuda, M.; Suzuki, A.; Aoki, D.; Fukuda, M. N., Identification of Mono- and Disulfated N-Acetyl-lactosaminyl Oligosaccharide Structures as Epitopes Specifically Recognized by Humanized Monoclonal Antibody HMOCC-1 Raised against Ovarian Cancer. J. Biol. Chem. 2012, 287 (9), 6592-6602.

    37.     Wang, P.; Li, X.; Zhu, J.; Chen, J.; Yuan, Y.; Wu, X.; Danishefsky, S. J., Encouraging Progress in the ω-Aspartylation of Complex Oligosaccharides as a General Route to β-N-Linked Glycopolypeptides. J. Am. Chem. Soc. 2011, 133 (5), 1597-1602.

    38.     Wang, P.; Danishefsky, S. J., Promising General Solution to the Problem of Ligating Peptides and Glycopeptides. J. Am. Chem. Soc. 2010, 132 (47), 17045-17051.

    39.     Wu, X.; Stockdill, J. L.; Wang, P.; Danishefsky, S. J., Total Synthesis of Cyclosporine: Access to N-Methylated Peptides via Isonitrile Coupling Reactions. J. Am. Chem. Soc. 2010, 132 (12), 4098-4100.

    40.     Chen, J.; Wang, P.; Zhu, J.; Wan, Q.; Danishefsky, S. J., A program for ligation at threonine sites: application to the controlled total synthesis of glycopeptides. Tetrahedron 2010, 66 (13), 2277-2283.

    41.     Wang, P.; Zhu, J.; Yuan, Y.; Danishefsky, S. J., Total Synthesis of the 2,6-Sialylated Immunoglobulin G Glycopeptide Fragment in Homogeneous Form. J. Am. Chem. Soc. 2009, 131 (46), 16669-16671.

    42.     Lee, H.; Wang, P.; Hoshino, H.; Ito, Y.; Kobayashi, M.; Nakayama, J.; Seeberger, P. H.; Fukuda, M., α1,4GlcNAc-capped mucin-type O-glycan inhibits cholesterol α-glucosyltransferase from Helicobacter pylori and suppresses H. pylori growth. Glycobiology 2008, 18 (7), 549-558.

    43.     Wang, P.; Lee, H.; Fukuda, M.; Seeberger, P. H., One-pot synthesis of a pentasaccharide with antibiotic activity against Helicobacter pylori. Chem. Commun. 2007, 38 (19), 1963-1965.

    44.     Lee, H.; Kobayashi, M.; Wang, P.; Nakayama, J.; Seeberger, P. H.; Fukuda, M., Expression cloning of cholesterol α-glucosyltransferase, a unique enzyme that can be inhibited by natural antibiotic gastric mucin O-glycans, from Helicobacter pylori. Biochem. Biophys. Res. Commun. 2006, 349 (4), 1235-1241.

    45.     Wang, P.; Zhang, Z.; Yu, B., Total Synthesis of CRM646-A and -B, Two Fungal Glucuronides with Potent Heparinase Inhibition Activities. J. Org. Chem. 2005, 70 (22), 8884-8889.

    46.     Yu, B.; Wang, P., Efficient Synthesis of the Hexasaccharide Fragment of Landomycin A:  Using Phenyl 2,3-O-Thionocarbonyl-1-thioglycosides as 2-Deoxy-β-glycoside Precursors. Org. Lett. 2002, 4 (11), 1919-1922.

     

    Books

    47.     Yin, H.; Zhou, Q.; Wang, S.; Wang, P., ”General solution to the preparation of ꞵ-thiolated/selenolated amino acids via visible light catalyzed asymmetric Giese reaction”. Humana, New York, NY. Methods in Molecular Biology, vol 2530, Chapter 8, https://doi.org/10.1007/978-1-0716-2489-0_8.

    48.    何春茂,王平,李学臣,董甦伟,刘磊. 《中国合成科学2035发展战略》,第十五章 蛋白质的合成.

     

    Patent

    49.     Jeffrey V. Ravetch, Andrew Pincetic, Ping Wang, Samuel J. Danishefsky, Human DC-SIGN binding peptides derived from IgG1 Fc fragment. PCT Int. Appl. 2013, WO 2013095973 A1 20130627.

    50.     Samuel J. Danishefsky, Ping Wang, Suwei Dong, Malcolm A. Moore, Jaehung Shieh, John A. Brailsford,. Homogenous and fully glycosylated human erythropoietin. PCT Int. Appl. (2013), WO 2013166053 A2 20131107. 


  • 软件版权登记及专利

    1.       Jeffrey V. Ravetch, Andrew Pincetic, Ping Wang, Samuel J. Danishefsky, Human DC-SIGN binding peptides derived from IgG1 Fc fragment. PCT Int. Appl. 2013, WO 2013095973 A1 20130627.

    2.       Samuel J. Danishefsky, Ping Wang, Suwei Dong, Malcolm A. Moore, Jaehung Shieh, John A. Brailsford,. Homogenous and fully glycosylated human erythropoietin. PCT Int. Appl. (2013), WO 2013166053 A2 20131107. 


  • 学术兼职

    中国化学会糖化学专业委员会委员

    中国生物物理学会糖生物学分会委员

    《中国化学》 Editorial Board Member of Spotlights2022


  • 荣誉奖励

    国家杰出青年科学基金

    海外高层次人才计划

  • 教学工作

    化学生物学、有机化学

  • 人才需求

    本课题组欢迎蛋白质、糖化学生物学、有机化学、药理以及免疫学背景的博士后加入,来信请发送至wangp1@sjtu.edu.cn

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电话:021-54742893
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