1998-2002：兰州大学化学化工学院，学士

2005-2010：兰州大学化学化工学院，博士（导师：涂永强院士）

2002-2010：兰州大学功能有机分子化学国家重点实验室

2010-2011：美国芝加哥大学 (The University of Chicago) 化学系，博士后（导师：何川教授）

2011-2014：美国宾夕法尼亚州立大学 (Penn State University) 化学系，博士后（导师：陈弓教授）

2015-2020：上海交通大学化学化工学院，特别研究员（长聘教轨副教授）

2020-2021：上海交通大学化学化工学院，院长助理

2021-2022：上海交通大学化学化工学院，长聘副教授

2022-至今： 上海交通大学化学化工学院，教授，副院长

以合成化学为基础和核心的学科交叉研究。

1） 全合成化学：以非活泼碳-氢键活化反应为核心的天然产物及活性药物分子的集体全合成；

2） 反应及计算：烯基轴手性化学、电化学重排反应、不对称C-N键构筑反应及DFT计算研究；

3） 先进材料：NIRII荧光探针，CPL探针，结合机器学习设计的先进PI材料。

感谢国家自然科学基金委、科技部重点研发计划、上海市科委、上海市教委、上海交通大学及海外青年人才项目经费支持！

近期代表性论文：

1) Machine learning for active sites prediction of quinoline derivatives
Jie Sun, Zi-Hao Li, * Yi-Fei Yang, Shu-Yu Zhang*
Artificial Intelligence Chemistry, 2025, 100082.

2) Organocatalytic asymmetric tandem reaction for the enantioselective synthesis of chiral oxindoles to construct CyK dyes
Le Wang, Zi-Hao Li, Di Wu, Rui-Tian Ge, Jia Zhou, Yin-Feng Zhang, Shu-Yu Zhang*
Chem Catal. 2025, 5, 101188.

3) Organocatalytic Asymmetric Synthesis of Sulfonyl-Substituted Furans via a Cascade 1,6-Addition/Cyclization/Enantioselective Protonation Pathway
Peng-Fei Lian, Zi-Hao Li*, Xin-Yue Qiu, Tong-Mei Ding, Shu-Yu Zhang*
ACS Catal. 2024, 14, 12717.

4) Asymmetric Intramolecular Amination Catalyzed with Cp*Ir-SPDO via Nitrene Transfer for Synthesis of Spiro-Quaternary Indolinone
Shi-Qiang Wei, Zi-Hao Li, Shuang-Hu Wang, Hua Chen, Xiao-Yu Wang, Yun-Zhou Gu, Ye Zhang, Hong Wang, Tong-Mei Ding, Shu-Yu Zhang,* Yong-Qiang Tu*
J. Am. Chem. Soc. 2024, 146, 18841.

5) Enantioselective sequential Michael addition/C-H olefination/Michael reaction for the efficient collective synthesis of clavine alkaloids
Zhi-Gang Ma,^† Yu Hao,^† Wei Jiang, Xian-Yu Pan, Tong-Mei Ding, Si-Hua Hou, Shu-Yu Zhang*
Cell Rep. Phys. Sci. 2024, 102112.

6) How achiral Brønsted acid involves in co-catalyst model with chiral phosphoric acid for construction of quaternary carbon stereocenter
Zi-Hao Li,^†  Jia Zhou,^† Chang Liu, Fu-Xin Tan, Le Wang, Guo-Dong Zhu, Shu-Yu Zhang*
Chem Catal. 2024, 4, 100918.

7) Cooperative Cu/azodiformate system-catalyzed allylic C–H amination of unactivated internal alkenes directed by aminoquinoline
Le Wang, Cheng-Long Wang, Zi-Hao Li, Peng-Fei Lian, Jun-Chen Kang, Jia Zhou, Yu Hao, Ru-Xin Liu, He-Yuan Bai, Shu-Yu Zhang*
Nature Commun. 2024, 15, 1483.

8) Asymmetric Intramolecular Hydroalkylation of Internal Olefin with Cycloalkanone to Directly Access Polycyclic Systems
Ai-Fang Wang, Jin-Miao Tian, Xiao-Jing Zhao, Zi-Hao Li, Ye Zhang, Ka Lu, Hong Wang, Shu-Yu Zhang,* Yong-Qiang Tu,* Tong-Mei Ding, Yu-Yang Xie
Angew Chem. Int. Ed. 2023, 62, e202308858.

9) Axially Chiral Styrene-Based Organocatalysts and Their Application in Asymmetric Cascade Michael/Cyclization Reaction
Yu Hao, Zi-Hao Li, Zhi-Gang Ma, Ru-Xin Liu, Rui-Tian Ge, Quan-Zhe Li, Tong-Mei Ding, and Shu-Yu Zhang*
Chem. Sci. 2023, 9496.

10) Electroreductive fluoroalkylative heteroarylationof unactivated alkenes via an unconventionalremote heteroaryl migration
Chao Chen, Shen-Yuan Zhang, Shuai-Xin Li, Zi-Hao Li, Ru-Xin Liu, Jun-Chen Kang, Tong-Mei Ding, and Shu-Yu Zhang*
Cell Rep. Phys. Sci. 2023, 4, 101385.

11) Synthetic strategies and mechanistic studies of axially chiral styrenes
Zi-Hao Li, Quan-Zhe Li, He-Yuan Bai, Shu-Yu Zhang*
Chem Catal. 2023, 3, 100594.

12) Bioinspired Palladium-Catalyzed Intramolecular C(sp3)−H Activation for the Collective Synthesis of Proline Natural Products
Quan-Zhe Li,^† Si-Hua Hou,^† Jun-Chen Kang, Peng-Fei Lian, Yu Hao, Chao Chen, Jia Zhou, Tong-Mei Ding and Shu-Yu Zhang*
Angew Chem. Int. Ed. 2022, 61, e202207088.

13) Molecular basis for cell-wall recycling regulation by transcriptional repressor MurR in Escherichia coli
Ya Zhang#, Weizhong Chen#, Di Wu#, Yushi Liu, Zhaowei Wu, Jian Li, Shu-Yu Zhang,*and Quanjiang Ji*
Nucleic Acids Research, 2022, 50, 5948.

14) CPA-Catalyzed Enantioselective Dearomative Electrophilic Hy-drazination : Access to Chiral Aza-Quaternary Carbon Indolenines
Xin-Yue Qiu, Zi-Hao Li, Jia Zhou, Peng-Fei Lian, Li-Kun Dong, Tong-Mei Ding, He-Yuan Bai, and Shu-Yu Zhang*
ACS Catal. 2022, 12, 7511.

15) Ni-Catalyzed, Enantioselective Three-component Radical Relayed Reductive Coupling of Alkynes: Synthesis of Axially Chiral Styrenes
Quan-Zhe Li, Zi-Hao Li, Jun-Chen Kang, Tong-Mei Ding, and Shu-Yu Zhang*
Chem Catal. 2022, 2, 3185.

更多发表论文请访问：

https://orcid.org/0000-0002-1811-4159

ResearchGate

https://www.scholarmate.com/P/v2ER3e?module=pub

祝贺练鹏飞、王乐同学顺利通过2024年度博士论文答辩！

祝贺刘汝欣同学顺利通过2024年度硕士论文答辩，获评"上海交大优秀毕业生"！

《上海交通大学学报自然科学版》青年编委

上海市手性药物分子工程重点实验室 副主任

2023: 全国大学生化学实验创新大赛华东赛区一等奖 指导教师

2023: 上海市化学化工优秀论文一等奖 指导教师

2022: 国家教学成果一等奖(R6)

2021: 上海交通大学“教书育人奖”

2021: Thieme Chemistry Journals Award

2020: 上海交通大学“优异学士学位论文(1%)指导教师”

2019: 上海交通大学“烛光奖”

2019: 上海交通大学“优秀班主任”

2016: 上海市曙光学者

2016: 国家自然科学二等奖(R5)

2015: 教育部自然科学一等奖(R5)

2015: 中组部青年人才计划

本科生：致远学院《Organometallic Chemistry》

研究生：化学化工学院《金属有机化学》、致远荣誉课程《高等有机化学》

承担本科生：大创项目、致远学者项目、莙政学者项目。

代表性教学学术研究：

1) Using Computational Chemistry to Improve Students' Multidimensional Understanding of Complex Electrophilic Aromatic Substitution Reactions: Further Analysis of the Solvent Effect, Temperature Influence, and Kinetic Behaviors
Li-Kun Dong, Zi-Hao Li, Shu-Yu Zhang*
J. Chem. Educ. 2021, 98, 3226-3236.

2) Project-Based Learning in Green Electrochemistry for Undergraduates: An Efficient Synthesis Route of Natural Product
Ru-Xin Liu, Feng Xiong, Chao Chen, Tong-Mei Ding, Shu-Yu Zhang*
J. Chem. Educ. 2023, 100, 689-696.

3) Bringing Green Organic Electrochemistry to Undergraduates: A Designed Comparison Organic Experiment of Bromination
Feng Xiong, Ru-Xin Liu, Xiao-Xuan Fan, Min Zhang, Yuan She, Wei-Qing Cao, Chao Chen, Tong-Mei Ding, and Shu-Yu Zhang*
J. Chem. Educ. 2023, 100, 4686-4695.

4) Using Computational Chemistry to Compare the Strength of Lewis Bases from HOMO Orbital Energy
Xin-Yu Chen, Zi-Hao Li,* Li-Kun Dong, Xie-Yang Jiang, and Shu-Yu Zhang*
Chin. J. Chem. Educ. 2024, 45, 38-44.

5) Stepwise or Concerted Mechanisms? Rethinking of the Classical Carbocation Rearrangement Reaction
Qing-Yun Cai, Hao Zheng, Zi-Hao Li, Li-Kun Dong, Jia Zhou, and Shu-Yu Zhang*
J. Chem. Educ. 2024, 101, 5068-5076.

课题组招生信息：

2025级研究生已招满，谢谢大家！

课题组开放支持本科生项目，欢迎随时联系和交流！

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