张书宇长聘副教授

电子邮件:zhangsy16@sjtu.edu.cn
通讯地址:上海市东川路800号上海交通大学化学化工学院B329

  • 教育背景

    1998-2002:兰州大学化学化工学院,学士

    2005-2010:兰州大学化学化工学院,博士(导师:涂永强院士)

  • 工作经历

    2002-2010:兰州大学功能有机分子化学国家重点实验室

    2010-2011:美国芝加哥大学(The University of Chicago)化学系,博士后(导师:何川教授)

    2011-2014:美国宾夕法尼亚州立大学(Penn State University)化学系,博士后(导师:陈弓教授)

    2015-2020:上海交通大学化学化工学院,特别研究员(长聘教轨副教授)

    2021-:        上海交通大学化学化工学院,特别研究员(长聘副教授)

  • 研究方向

    1) 以非活泼碳-氢键活化反应为核心的天然产物及活性药物分子的全合成;

    2) 涉及多种化学键构建的非活泼C-H键活化新反应、电化学反应、及不对称反应的研究;

    3) 与化学生物学相结合的化学反应方法、仿生合成、及合成生物学研究。

  • 科研项目

    感谢国家自然科学基金委、上海市科委、上海市教委、上海交通大学及海外青年人才项目经费支持!


  • 代表性论文专著

    近期发表论文

    2019

    1) Highly Atroposelective Synthesis of Nonbiaryl Naphthalene-1,2-diamine N-C Atropisomers through Direct Enantioselective C-H Amination
    H.-Y. Bai, F.-X. Tan, T.-Q. Liu, G.-D. Zhu, J.-M. Tian, T.-M. Ding, Z.-M. Chen, S.-Y. Zhang*
    Nat. Commun. 2019, 10. 3063. (Editor's highlights)

    2) Electrochemical Halogenation/Semi-pinacol Rearrangement of Allylic Alcohols Using Inorganic Halide Salt: An Eco-friendly Route to Synthesis of β-halocarbonyls
    C. Chen, J.-C. Kang, C. Mao, J.-W. Dong, Y.-Y. Xie, T.-M. Ding, Y.-Q. Tu, Z.-M. Chen,* S.-Y. Zhang*
    Green Chem. 2019, 21, 4014. (Inside front cover)

    3) Remote C6-Enantioselective C−H Functionalization of 2,3-Disubstituted Indoles through the Dual H‑Bonds and π−π Interaction Strategy Enabled by CPAs
    J. Zhou, G.-D. Zhu, L. Wang, F.-X. Tan, W. Jiang, Z.-G. Ma, J.-C. Kang, S.-H. Hou, S.-Y. Zhang*
    Org. Lett. 2019, 21, 8662.

    4) Dienamine-Mediated Deconjugative Addition/Cyclization Cascade of γ, γ-Disubstituted Enals with Carboxylic Acid-Activated Enones: A Rapid Access to Highly Functionalized γ-Lactones
    W. Jiang, J. Zhou, A.-J. Ma, D. Li, Y.-Y. Ma, D.-G. Zhao, S.-H. Hou, J.-B. Lin*, S.-Y. Zhang*
    Org. Chem. Front. 2019, DOI: 10.1039/C9QO01367A

    5) Design and synthesis of a novel quinoxaline diamine and its polyimides with high-Tg and red color
    T.-Q. Liu, F. Zheng, T.-M. Ding, S.-Y. Zhang,*  Q. Lu*
    Polymer 2019, 179, 121612.

    6) Asymmetric N-hydroxyalkylaltion of Indoles with Ethyl Glyoxalates Catalyzed by a Chiral Phosphoric Acid: Highly Enantioselective Synthesis of Chiral N,O-aminal Indole Derivatives
    L. Wang, J. Zhou, T.-M. Ding, Z.-Q. Yan, G.-D. Zhu,* S.-Y. Zhang*
    Org. Lett. 2019, 21, 2795.

    7) Electrochemical Semipinacol Rearrangements of Allylic Alcohols: Construction of All-Carbon Quaternary Stereocenters
    J.-C. Kang, Y.-Q. Tu, J.-W. Dong, C. Chen, J. Zhou, T.-M. Ding, J.-T. Zai, Z.-M. Chen,* S.-Y. Zhang*
    Org. Lett. 2019, 21, 2536.

    8) Dual Directing Groups-Assisted Redox-Neutral Annulation and Ring-Opening of N-Aryloxyacetamides with 1-Alkynylcyclobutanols via Rhodium(III)-Catalyzed C–H/C–C Activations
    J.-L. Pan, C. Liu, C. Chen, T.-Q. Liu, M. Wang, Z. Sun,* S.-Y. Zhang*
    Org. Lett. 2019, 21, 2823.

    9) Asymmetric Organocatalytic Synthesis of 2,3-Allenamides from Hydrogen Bond-Stabilized Enynamides
    Z.-G. Ma, J.-L. Wei, J.-B. Lin, G.-J. Wang, J. Zhou, K. Chen, C.-A. Fan* and S.-Y. Zhang*
    Org. Lett. 2019, 21, 2468.

    10) Computational and Experimental Studies on Copper-Catalyzed Selective Cascade C-H/N-H Annulation of Electron-Deficient Acrylamide with Arynes
    C. Chen, Y. Hao, T.-Y. Zhang, J.-L. Pan, J. Ding, H.-Ye Xiang, M. Wang, T.-M. Ding, A. Duan,* S.-Y. Zhang*
    Chem. Commun. 2019, 55, 755. (Inside front cover designed by Chen Mao, freshman at SJTU)

    2018

    1) Rhodium(III)-Catalyzed Redox-Neutral Cascade [3 + 2] Annulation of N‑Phenoxyacetamides with Propiolates via C−H Functionalization/Isomerization/Lactonization

    J.-L. Pan, P. Xie, C. Chen, Y. Hao, C. Liu, H.-Y. Bai, J. Ding, L.-R. Wang, Y. Xia,* and S.-Y. Zhang*

    Org. Lett.2018, 20, 7131.

    2) A Facile Approach to Oximes and Ethers by aTandem NO+-Initiated Semipinacol Rearrangement and H-Elimination

    J.-W. Dong, T.-M. Ding, S.-Y. Zhang,* Z.-M. Chen,* and Y.-Q. Tu*

    Angew. Chem. Int. Ed.2018, 57, 13192.

    3) Transition Metal-Controlled Direct Regioselective Intermolecular Amidation of C−H Bonds with Azodicarboxylates: Scope, Mechanistic Studies, and Applications

    H.-Y. Bai, X. Fu, J.-L. Pan, H.-Q. Ma, Z.-M. Chen, T.-M. Ding,* and S.-Y. Zhang*

    Adv. Synth. Catal. 2018, 360, 4205. (Full Paper)

    4) Experimental and computational studies on H2O-promoted, Rh-catalyzed transient-ligand free ortho-C(sp2)–H amidation of benzaldehydes with dioxazolones

    J. Ding, W. Jiang, H.-Y. Bai, T.-M. Ding, D. Gao, X. Bao* and S.-Y. Zhang *

    Chem. Commun. 2018, 54, 8889.

    5) Metal-Controlled, Regioselective, Direct Intermolecular α- or γ‑Amination with Azodicarboxylates

    X. Fu, H.-Y. Bai, G.-D. Zhu, Y. Huang,*, and S.-Y. Zhang*

    Org. Lett.2018, 20, 3469.

    6) Copper-Mediated Cascade C−H/N−H Annulation of Indolocarboxamides with Arynes: Construction of Tetracyclic Indoloquinoline Alkaloids

    T.-Y. Zhang, C. Liu, C. Chen, J.-X. Liu, H.-Y. Xiang, W. Jiang, T.-M. Ding, S.-Y. Zhang*

    Org. Lett.2018, 20, 220.

    7) Mechanistic insights into staphylopine-mediated metal acquisition

    L. Song, Y. Zhang, W. Chen, T. Gu, S.-Y. Zhang, and Q. Ji*

    PNAS, 2018, 115, 3942.

    8) Recent progress in the isolation, bioactivity, biosynthesis, and total synthesis of natural spiroketals

    F.-M. Zhang, S.-Y. Zhang and Y.-Q. Tu*

    Nat. Prod. Rep. 2018, 35, 75.

    2017

    1) Stereoselective Synthesis of Z Vinylsilanes via Palladium-Catalyzed Direct Intermolecular Silylation of C(sp2)−H Bonds

    J.-L. Pan, C. Chen, Z.-G. Ma, J. Zhou, L.-R. Wang, S.-Y. Zhang*

    Org. Lett.2017, 19, 5216.

    2) Copper-Catalyzed Selective ortho-C−H/N−H Annulation of Benzamides with Arynes: Synthesis of Phenanthridinone Alkaloids

    T.-Y. Zhang, J.-B. Lin, Q.-Z. Li, J.-C. Kang, J.-L. Pan, S.-H. Hou, C. Chen, S.-Y. Zhang*

    Org. Lett. 2017, 19, 1764.

    3) Palladium-Catalyzed Direct Intermolecular Amination of Unactivated Methylene C(sp3)−H Bonds with Azodiformates via Bidentate-Chelation Assistance

    H.-Y. Bai, Z.-G. Ma, M. Yi, J.-B. Lin, S.-Y. Zhang*

    ACS Catal.2017, 7, 2042.

    2016

    1) Palladium-catalyzed direct intermolecular silylation of remote unactivated C(sp3)-H bonds

    J.-L. Pan, Q.-Z. Li, T.-Y. Zhang, S.-H. Hou, J.-C. Kang, S.-Y. Zhang*

    Chem. Commun. 2016, 52, 13151.


    代表性论文

    1) S.-Y. Zhang, Q. Li, G. He, W. A. Nack, and G. Chen*

    J. Am. Chem. Soc. 2015, 137, 531. (ESI Highly Cited Paper, ESI Hot Paper)

    2) S.-Y. Zhang, Q. Li, G. He, W. A. Nack, and G. Chen*

    J. Am. Chem. Soc. 2013, 135, 12135. (ESI Highly Cited Paper)

    3) S.-Y. Zhang, G. He, W. A. Nack, Y. Zhao, Q. Li, and G. Chen*

    J. Am. Chem. Soc. 2013,135, 2124. (ESI Highly Cited Paper)

    4) S.-Y. Zhang, G. He, Y. Zhao, K. Wright, W. A. Nack, and G. Chen*

    J. Am. Chem. Soc. 2012, 134, 7313. (ESI Highly Cited Paper)

    5) S.-Y. Zhang, F.-M. Zhang and Y.-Q. Tu*

    Chem. Soc. Rev. 2011, 40, 1937. (ESI Highly Cited Paper)

    6) S.-Y. Zhang, Y.-Q. Tu,* C.-A. Fan, F.-M. Zhang, and L. Shi

    Angew. Chem. Int. Ed. 2009, 48, 8761. (Angew Hot Paper, Most accessed)

  • 荣誉奖励

    2021 上海交通大学“教书育人奖”

    2021 Thieme Chemistry Journals Award

    2020 上海交通大学“优异学士学位论文(1%)指导教师”

    2019 上海交通大学“烛光奖”

    2019 上海交通大学“优秀班主任”

    2016 上海市曙光学者

    2016 国家自然科学二等奖(R5)

    2015 教育部自然科学一等奖(R5)

    2015 中组部人才计划

  • 教学工作

    本科生:致远学院《Organometallic Chemistry》

    研究生:化学化工学院《金属有机化学》、致远荣誉课程《高等有机化学》

  • 人才需求

    课题组招生信息:

    2022年:硕、博招生已满!

    2023年:博士招生已满,硕士招生可申请!

    博士后申请请通过email联系!

地址:上海市东川路800号 200240
电话:021-54742893
E-mail:sjtuscce@sjtu.edu.cn

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