电子邮件:YanganY_Li@sjtu.edu.cn
通讯地址:上海市闵行区东川路800号上海交通大学化学化工学院
2005年9月-2009年6月:武汉大学,药学院,药学,学士
2010年9月-2012年6月:武汉大学,药学院,药物化学,硕士 (导师:洪学传 教授)
2012年9月-2016年11月:华东师范大学,化学与分子工程学院,有机化学,博士 (导师:张俊良 教授)
2017年3月-2017年5月:上海润诺生物科技有限公司,有机合成高级研究员
2017年6月-2021年3月:湖南科技学院,制药工程系,讲师
2021年4月至今:上海交通大学化学化工学院,助理研究员
核苷(酸)的化学修饰与应用
1.湖南省自然科学基金青年基金,2018JJ3195,已结题
2.国家自然科学基金青年基金,21801075,已结题
3.上海交通大学医工交叉研究基金,YG2022QN019,在研
(16) Yangyan Li,‡ Yutong Zhou,‡ Dazhi Zhou,‡ Yujie Jiang, Madiha Butt, Hui Yang, Yingchuan Que, Zhiming Li,* Gang Chen,* Regioselective Homolytic C2–H Borylation of Unprotected Adenosine and Adenine Derivatives via Minisci Reaction. J. Am. Chem. Soc. 2024, 146, 21428.
(15) Ruoqian Xie, Wanlu Li, Yuhua Ge*, Yutong Zhou, Guolan Xiao, Qin Zhao, Yunxi Han, Yangyan Li, Gang Chen*, Late-stage guanine C8–H alkylation of nucleosides, nucleotides, and oligonucleotides via photo-mediated Minisci reaction. Nat. Commun. 2024, 15, 2549.
(14) Yuhua Ge*, Yijiang Peng, Ruoqian Xie, Yang Luo, Yangyan Li*, Gang Chen*, Visible Light-mediated Late-stage Thioetherification of Mercaptopurine Derivatives. Chem. Eur. J., 2024, 30, e202401774.
(13) Qin Zhao, Ruoqian Xie, Yuxiao Zeng, Wanlu Li, Guolan Xiao, Yangyan Li*, Gang Chen*, Palladium-catalyzed C–H Olefination of Uridine, Deoxyuridine, Uridine Monophosphate and Uridine Analogues, RSC Adv., 2022, 12, 24930.
(12) Yuhua Ge*, Xingyue Chen, Yi Dong, Hua-Nan Wang, Yangyan Li, Gang Chen*, Access to benzene-modified 2nd generation strigolactams and GR24 by merging C-H olefination with decarboxylative Giese cyclization, Org. Biomol. Chem., 2021, 19, 7141.
(11) Yangyan Li#, Le Tu#, Xin Ma, Huan Chen, Yifan Fan, Qiang Zhou, Yao Sun*, Engineering a Smart Nanofluidic Sensor for High-performance Peroxynitrite Sensing Through a Spirocyclic Ring Open/Close Reaction Strategy, ACS Sens., 2021, 6, 3, 808.
(10) Qingying Ouyang, Le Tu, Yi Zhang, Huan Chen, Yifan Fan, Yingfeng Tu*, Yangyan Li*, and Yao Sun*, Construction of a Smart Nanofluidic Sensor through a Redox Reaction Strategy for High-Performance Carbon Monoxide Sensing, Anal. Chem., 2020, 92, 14947.
(9) Xinsheng Xiao*, Sanping Huang, Shanshan Tang, Guokai Jia, Guangchuan Ou and Yangyan Li*, Ligand-free, Quinoline N-assisted Copper-catalyzed Nitrene Transfer Reaction to Synthesize 8-quinolylsulfimides, J. Org. Chem., 2019, 84, 7618.
(8) Qingwen Gui, Kang Han, Zhuoliang Liu, Zhaohong Su, Xiaoli He, Hongmei Jiang*, Bufan Tian and Yangyan Li*, E-Selective synthesis of vinyl sulfones via silver-catalyzed sulfonylation of styrenes, Org. Biomol. Chem., 2018, 16, 5748.
(7) Yangyan Li, Xiang Chen, Xiaoming Chen and Xiao Shen*, Organophosphine-Catalyzed [4C+X] Annulations, Molecules, 2018, 23, 3022.
(6) Yangyan Li, Chao-Ze Zhu, Junliang Zhang*, Gold-Catalyzed [4+3] Cycloaddition/C–H Functionalization Cascade: Regio- and Diastereoselective Route to Cyclohepta[b]indoles. Eur. J. Org. Chem., 2017, 6609.
(5) Yangyan Li, WenboLi, Junliang Zhang*, Gold-Catalyzed Enantioselective Annulations. Chem. Eur. J., 2017, 23, 467.
(4) Yangyan Li, Xiao Su, Wei Zhou, Wenbo Li, Junliang Zhang*, Amino Acid Derived Phosphine-Catalyzed Enantioselective 1,4-Dipolar Spiroannulation of Cyclobutenones and Isatylidenemalononitrile. Chem. Eur. J., 2015, 21, 4224.
(3) Xiao Su#, Wei Zhou#, Yangyan Li, Junliang Zhang*, Design, Synthesis, and Application of a Chiral Sulfinamide Phosphine Catalyst for the Enantioselective Intramolecular Rauhut-Currier Reaction. Angew. Chem. Int. Ed., 2015, 54, 6874.
(2) Maomao He, Chunrong Qu, Bingbing Ding, Hao Chen, Yangyan Li, Guofu Qiu, Xianming Hu, Xuechuan Hong*, Total Synthesis of (±)-8-Oxo-erythrinine, (±)-8-Oxo-erythraline, and (±)-Clivonine, Eur. J. Org. Chem., 2015, 15, 3240.
(1) Hao Chen, Maomao He, Yaya Wang, Linhui Zhai, Yongbo Cui, Yangyan Li, Yan Li, Haibing Zhou*, Xuechuan Hong*, Zixin Deng, Metal-free direct amidation of peptidyl thiol esters with α-amino acid esters. Green Chem., 2011, 13, 2723.
(5) 陈刚,葛裕华,李婉露,赵芹,谢若芊,李杨燕,肖国兰. 一种烷基化核苷、核苷酸、寡核苷酸及其类似物的制备方法[P]. 中国专利:CN117343119A。
(4) 肖新生,李杨燕,龚绍峰,谢建伟,胡姣. 一种芳并二氢吡咯[2,3]并环丁烷类化合物及其合成方法[P]. 中国专利:CN114634443A。
(3) 唐珊珊,肖新生,李杨燕. 一种催化转移氢化硝基环己烷制备环己酮肟的方法[P]. 中国专利:CN109160887A。
(2) 肖新生,李杨燕,欧光川,唐珊珊,刘芳,权婷,黄三萍. S-烷基-S-喹啉基-N-磺酰基氮硫叶立德化合物及其制备和应用[P]. 中国专利:CN109810056A。
(1) 张俊良,宿晓,周伟,李杨燕. 一种手性叔膦化合物及其全构型、制备方法和应用[P]. 中国专利:CN104817591A。