李杨燕助理研究员

电子邮件:YanganY_Li@sjtu.edu.cn
通讯地址:上海市闵行区东川路800号上海交通大学化学化工学院

  • 教育背景

    2005年9月-2009年6月:武汉大学,药学院,药学,学士
    2010年9月-2012年6月:武汉大学,药学院,药物化学,硕士 (导师:洪学传  教授)
    2012年9月-2016年11月:华东师范大学,化学与分子工程学院,有机化学,博士 (导师:张俊良  教授)

  • 工作经历

    2017年3月-2017年5月:上海润诺生物科技有限公司,有机合成高级研究员
    2017年6月-2021年3月:湖南科技学院,制药工程系,讲师
    2021年4月至今:上海交通大学化学化工学院,助理研究员

  • 研究方向

    核苷(酸)的化学修饰与应用

  • 科研项目

    1.湖南省自然科学基金青年基金,2018JJ3195,已结题

    2.国家自然科学基金青年基金,21801075,已结题

    3.上海交通大学医工交叉研究基金,YG2022QN019,在研


  • 代表性论文专著

    (16) Yangyan Li,‡ Yutong Zhou,‡ Dazhi Zhou,‡ Yujie Jiang, Madiha Butt, Hui Yang, Yingchuan Que, Zhiming Li,* Gang Chen,* Regioselective Homolytic C2–H Borylation of Unprotected Adenosine and Adenine Derivatives via Minisci Reaction. J. Am. Chem. Soc. 2024, 146, 21428.

    (15) Ruoqian Xie, Wanlu Li, Yuhua Ge*, Yutong Zhou, Guolan Xiao, Qin Zhao, Yunxi Han, Yangyan Li, Gang Chen*, Late-stage guanine C8–H alkylation of nucleosides, nucleotides, and oligonucleotides via photo-mediated Minisci reaction. Nat. Commun. 2024, 15, 2549.

    (14) Yuhua Ge*, Yijiang Peng, Ruoqian Xie, Yang Luo, Yangyan Li*, Gang Chen*Visible Light-mediated Late-stage Thioetherification of Mercaptopurine Derivatives. Chem. Eur. J.202430, e202401774.

    (13)  Qin Zhao, Ruoqian Xie, Yuxiao Zeng, Wanlu Li, Guolan Xiao, Yangyan Li*, Gang Chen*, Palladium-catalyzed C–H Olefination of Uridine, Deoxyuridine, Uridine Monophosphate and Uridine Analogues, RSC Adv., 2022, 12, 24930. 

    (12) Yuhua Ge*, Xingyue Chen, Yi Dong, Hua-Nan Wang, Yangyan Li, Gang Chen*, Access to benzene-modified 2nd generation strigolactams and GR24 by merging C-H olefination with decarboxylative Giese cyclization, Org. Biomol. Chem., 2021, 19, 7141. 

    (11) Yangyan Li#, Le Tu#, Xin Ma, Huan Chen, Yifan Fan, Qiang Zhou, Yao Sun*, Engineering a Smart Nanofluidic Sensor for High-performance Peroxynitrite Sensing Through a Spirocyclic Ring Open/Close Reaction Strategy, ACS Sens., 2021, 6, 3, 808.

    (10)  Qingying Ouyang, Le Tu, Yi Zhang, Huan Chen, Yifan Fan, Yingfeng Tu*, Yangyan Li*, and Yao Sun*, Construction of a Smart Nanofluidic Sensor through a Redox Reaction Strategy for High-Performance Carbon Monoxide Sensing, Anal. Chem., 2020, 92, 14947. 

    (9)  Xinsheng Xiao*, Sanping Huang, Shanshan Tang, Guokai Jia, Guangchuan Ou and Yangyan Li*, Ligand-free, Quinoline N-assisted Copper-catalyzed Nitrene Transfer Reaction to Synthesize 8-quinolylsulfimides, J. Org. Chem., 201984, 7618.

    (8)  Qingwen Gui, Kang Han, Zhuoliang Liu, Zhaohong Su, Xiaoli He, Hongmei Jiang*, Bufan Tian and Yangyan Li*, E-Selective synthesis of vinyl sulfones via silver-catalyzed sulfonylation of styrenes, Org. Biomol. Chem., 2018, 16, 5748. 

    (7) Yangyan Li, Xiang Chen, Xiaoming Chen and Xiao Shen*, Organophosphine-Catalyzed [4C+X] Annulations, Molecules, 2018, 23, 3022. 

    (6) Yangyan Li, Chao-Ze Zhu, Junliang Zhang*, Gold-Catalyzed [4+3] Cycloaddition/C–H Functionalization Cascade: Regio- and Diastereoselective Route to Cyclohepta[b]indoles. Eur. J. Org. Chem., 2017, 6609. 

    (5) Yangyan Li, WenboLi, Junliang Zhang*, Gold-Catalyzed Enantioselective Annulations. Chem. Eur. J., 2017, 23, 467.

    (4) Yangyan Li, Xiao Su, Wei Zhou, Wenbo Li, Junliang Zhang*, Amino Acid Derived Phosphine-Catalyzed Enantioselective 1,4-Dipolar Spiroannulation of Cyclobutenones and Isatylidenemalononitrile. Chem. Eur. J.2015, 21, 4224.  

    (3) Xiao Su#, Wei Zhou#, Yangyan Li, Junliang Zhang*, Design, Synthesis, and Application of a Chiral Sulfinamide Phosphine Catalyst for the Enantioselective Intramolecular Rauhut-Currier Reaction. Angew. Chem. Int. Ed., 2015, 54, 6874.

    (2) Maomao He, Chunrong Qu, Bingbing Ding, Hao Chen, Yangyan Li, Guofu Qiu, Xianming Hu, Xuechuan Hong*, Total Synthesis of (±)-8-Oxo-erythrinine, (±)-8-Oxo-erythraline, and (±)-Clivonine, Eur. J. Org. Chem., 2015, 15, 3240. 

    (1) Hao Chen, Maomao He, Yaya Wang, Linhui Zhai, Yongbo Cui, Yangyan Li, Yan Li, Haibing Zhou*, Xuechuan Hong*, Zixin Deng, Metal-free direct amidation of peptidyl thiol esters with α-amino acid esters. Green Chem., 2011, 13, 2723.


  • 软件版权登记及专利

    (5) 陈刚,葛裕华,李婉露,赵芹,谢若芊,李杨燕,肖国兰. 一种烷基化核苷、核苷酸、寡核苷酸及其类似物的制备方法[P]. 中国专利:CN117343119A。

    (4) 肖新生,李杨燕,龚绍峰,谢建伟,胡姣. 一种芳并二氢吡咯[2,3]并环丁烷类化合物及其合成方法[P]. 中国专利:CN114634443A。

    (3) 唐珊珊,肖新生,李杨燕. 一种催化转移氢化硝基环己烷制备环己酮肟的方法[P]. 中国专利:CN109160887A。

    (2)  肖新生,李杨燕,欧光川,唐珊珊,刘芳,权婷,黄三萍. S-烷基-S-喹啉基-N-磺酰基氮硫叶立德化合物及其制备和应用[P]. 中国专利:CN109810056A。

    (1) 张俊良,宿晓,周伟,李杨燕. 一种手性叔膦化合物及其全构型、制备方法和应用[P]. 中国专利:CN104817591A。

地址:上海市东川路800号 200240
电话:021-54742893
E-mail:sjtuscce@sjtu.edu.cn

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