2007.09 - 2013.07 北京大学，前沿交叉学科研究院，博士

2002.09 - 2006.07 南昌大学，生命科学学院，学士

2024.06 -至今 上海交通大学，化学化工学院，长聘教轨副教授

2018.07 -2023.06 耶鲁大学，分子生物物理学与生物化学系，研究科学家

2014.07 -2018.07 耶鲁大学，细胞生物学系，博士后

方向一：AI辅助生物分子设计与酶工程

利用人工智能与分子工程技术开展酶和功能蛋白的设计、优化与创制，发展新型生物催化剂和功能分子。

方向二：DNA纳米反应器与分子组装

基于DNA纳米技术构建可编程分子组装体系，实现功能分子的精准组织与协同调控，发展新型DNA纳米反应器和人工分子系统。

方向三：仿生分子机器与智能生物器件

构建具有感知、响应和信息处理功能的仿生分子机器，发展生物电极、DNA生物芯片等智能器件，探索生物分子与电子系统的深度融合。

化学生物协同物质创制全国重点实验室资助项目，2025-2026，主持

国家重点研发计划项目，2025-2029，参与

国家自然科学基金面上项目，2025-2029，主持

国家海外高层次引进人才计划，2024-2026，主持

22.      Q. Feng, M. Saladin, C. Wu, E. Cao, W. Zheng, A. Zhang, P. Bhardwaj, X. Li, Q. Shen, L. E Kapinos, T. Kozai, M. Mariappan, C. Lusk, Y. Xiong, R. YH Lim, C. Lin. "Channel width modulates the permeability of DNA origami–based nuclear pore mimics", Sci Adv, 2024, 10, eadq8773.

21.      Q. Shen, Q. Feng, Q. Xiong, C. Wu, Y. Yuan, T. Tian, S. Yuan, J. Temple, C. Aiken, A.N. Engelman, C.P. Lusk, C. Lin, and Y. Xiong, "Modeling HIV-1 nuclear entry with nucleoporin-gated DNA-origami channels", Nature Structural & Molecular Biology, 2023, 30, 425-435.

20.      Q. Shen, S. Kumari, C. Xu, S. Jang, J. Shi, R.C. Burdick, L. Levintov, Q. Xiong, C. Wu, S.C. Devarkar, T. Tian, T.N. Therese, Y. Hu, S. Yuan, J. Temple, Q. Feng, P. Lusk, C. Aiken, A.N. Engelman, J. Perilla, V.K. Pathak, C. Lin, and Y. Xiong, "The capsid lattice engages a bipartite NUP153 motif to mediate nuclear entry of HIV-1 cores", Proc Natl Acad Sci USA, 2023, 120, e2202815120.

19.      Q. Shen^#, Q. Xiong^#, K. Zhou, Q. Feng, L. Liu, T. Tian, C. Wu, Y. Xiong, T.J. Melia, C.P. Lusk, and C. Lin, "Functionalized DNA-Origami-Protein Nanopores Generate Large Transmembrane Channels with Programmable Size-Selectivity", J Am Chem Soc, 2023, 145, 1292–1300.

18.      P. Zhan, A. Peil, Q. Jiang, D. Wang, S. Mousavi, Q. Xiong, Q. Shen, Y. Shang, B. Ding, C. Lin, Y. Ke, and N. Liu. "Recent Advances in DNA Origami-Engineered Nanomaterials and Applications", Chem Rev, 2023, 123, 3976-4050.

17.      W. Luo, V. Demidov, Q. Shen, H. Girão, M. Chakraborty, A. Maiorov, F. Ataullakhanov, C. Lin, H. Maiato, E. Grishchuk. "CLASP2 recognizes tubulins exposed at the microtubule plus-end in a nucleotide-state sensitive manner", Sci Adv, 2023, 9, eabq5404.

16.      Q. Shen, C. Wu, C. Freniere, T. N. Tripler, Y. Xiong. "Nuclear Import of HIV-1", Viruses, 2021, 13, 2242.

15.      Q. Shen, T. Tian, Q. Xiong, P.D.E. Fisher, Y. Xiong, T.J. Melia, C.P. Lusk, and C. Lin, "DNA-Origami NanoTrap for Studying the Selective Barriers Formed by Phenylalanine-Glycine-Rich Nucleoporins", J Am Chem Soc, 2021, 143, 12294-12303. Faculty Opinions recommended.

14.      Q. Shen and C. Lin. "RNA returns to the fold", Nature Chemistry, 2020, 12, 221-222.

13.  S. Yuan, L Peng, J. J. Park, Y. Hu, S. C. Devarkar, M. B. Dong, Q. Shen, S. Wu, S. Chen, I. B. Lomakin, and Y. Xiong. "Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA", Mol Cell, 2020, 80, 1-12.

12.  J. Temple^#, T.N. Tripler^#, Q. Shen^#, Y. Xiong. "A snapshot of HIV-1 capsid–host interactions", Curr Res Struct Biol, 2020, 2, 222-228.

11.  Q. Shen, M.W. Grome, Y. Yang, and C. Lin. "Engineering Lipid Membranes with Programmable DNA Nanostructures", Adv Biosyst, 2020, 4, 1900215.

10.  Q. Xiong, C. Xie, Z. Zhang, L. Liu, J. Powell, Q. Shen, and C. Lin, "DNA Origami Post-Processing by CRISPR-Cas12a", Angew Chem Int. Edit, 2020, 59, 3956-3960.

9.  Y. Hu, K. Knecht, Q. Shen, Y. Xiong, "Multifaceted HIV-1 Vif interactions with Human E3 Ubiquitin Ligase and APOBEC3s". FEBS J., 2020, 288, 3407-3417.

8.  G. Stanley, B. Akpinar, Q. Shen, PDE. Fisher, C.P. Lusk, C. Lin, and B. Hoogenboom, "Quantification of Biomolecular Dynamics Inside Real and Synthetic Nuclear Pore Complexes Using Time-Resolved Atomic Force Microscopy", ACS Nano, 2019, 13, 7949-7956.

7.  P. Fisher^#, Q. Shen^#, B. Akpinar, L. Davis, K. Chung, D. Baddeley, A. Šarić, T. Melia, B. Hoogenboom, C. Lin, and P. Lusk. "A Programmable DNA Origami Platform for Organizing Intrinsically Disordered Nucleoporins within Nanopore Confinement", ACS Nano, 2018, 2, 1508-1518. (co-first author position determined by coin toss)

6.  X. Deng, X. Zhang, B. Tang, H. Liu, Q. Shen, Y. Liu, and L. Lai. "Design, Synthesis, and Evaluation of Dihydrobenzo indole-6-sulfonamide as TNF-α Inhibitors", Front Chem, 2018, 4, 00098.

5.  Q. Shen^#, C. Zhang^#, J. Cao, Y. Liu, Y. Liang, M. Zhao, and L. Lai. "De novo design of helical peptides to inhibit TNFα by disrupting its trimer formation", MedChemComm, 2016, 7, 725-729.

4.  C. Zhu, C. Zhang, T. Zhang, X. Zhang, Q. Shen, B. Tang, H. Liang, and L. Lai, "Rational design of TNFα binding proteins based on the de novo designed protein DS119", Protein Sci, 2016, 25(11), 2066-2075.

3.  Q. Shen^#, J. Chen^#, Q. Wang, X. Deng, and L. Lai. "Discovery of highly potent TNFα inhibitors using virtual screening", Eur J Med Chem, 2014, 65, 119-126.

2.  H. Chen, Y. Zhao, H. Li, D. Zhang, Y. Huang, Q. Shen, R. Duyne, F. Kashanchi, C. Zeng, and S. Liu. "Break CDK2/cyclin E1 interface allosterically with small peptides", PLoS One, 2014, 9, e109154.

1.  C. Zhang^#, Q. Shen^#, B. Tang, and L. Lai. "Computational design of helical peptides targeting TNFα", Angew Chem Int Edit, 2013, 52, 11059-1106.

共同一作（#），通讯作者（_*）

2023年，罗伯特德克斯分子编程奖，国际纳米科学、计算和工程学会

2023年，国家高层次青年人才计划

          长期招收来自生物、化学、生物医学工程、计算机及相关交叉学科的本科生、研究生和博士后，可直接联系导师（qishen@sjtu.edu.cn）。

          我们更看重对科学问题的好奇心、探索未知的热情和严谨诚信的科研品格。希望成员具备独立思考能力、团队合作精神和迎接挑战的勇气。欢迎热爱科研、勤奋自律、勇于创新的同学加入，共同探索分子设计与DNA纳米工程的前沿科学问题。