陈建中副研究员

办公电话:021-34207243-311
电子邮件:0091109001@sjtu.edu.cn
通讯地址:药学楼7-311室

  • 教育背景

    2009 – 2013,上海交通大学,博士(导师:张万斌 讲席教授)
    2006 – 2009,华东理工大学,硕士(导师:赵敏 副教授)
    2000 – 2004,浙江工业大学,学士

  • 工作经历

    2019 – 至今,上海交通大学,副研究员
    2015 – 2019,上海交通大学,助理研究员
    2013 – 2015,上海交通大学,博士后(合作导师:颜德岳 院士)
    2004 – 2006,生物医药公司,研发员

  • 研究方向

    1)催化反应的研究,如不对称氢化;新型配体的设计、合成及应用
    2)药物和香料等合成工艺研究

  • 科研项目

    主持国家自然科学基金青年及面上项目,上海市自然科学基金面上等科研项目,参与国家自然科学基金重点项目,国际合作项目、企业合作项目等。

  • 代表性论文专著

    (1) Jing Guan, Jianzhong Chen, Yicong Luo, Lisen Guo, and Wanbin Zhang*, "Copper-Catalyzed Chemoselective Asymmetric Hydrogenation of C=O Bonds of Exocyclic α,β-Unsaturated Pentanones".  Angew. Chem. Int. Ed. 202362, e202306380. DOI: 10.1002/anie.202306380.

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    (2) Hanlin Wei, Hao Chen, Jianzhong Chen*, Ilya. D. Gridnev* and Wanbin Zhang*, "Nickel-Catalyzed Asymmetric Hydrogenation of α-Substituted Vinylphosphonates and Diarylvinylphosphine Oxides" Angew. Chem. Int. Ed. 202362, e202214990. DOI: 10.1002/anie.202214990. 

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    (3) Bowen Li, Jianzhong Chen, Dan Liu, Ilya D. Gridnev, and Wanbin Zhang*, "Nickel-catalysed asymmetric hydrogenation of oximes", Nature Chem. 2022, 14, 920-927(DOI: 10.1038/s41557-022-00971-8).

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    (4) Dan Liu, Bowen Li, Jianzhong Chen, Ilya D. Gridnev, Deyue Yan and Wanbin Zhang*, “Ni-Catalyzed Asymmetric Hydrogenation of N-Aryl Imino Esters for the Efficient Synthesis of Chiral α-Aryl Glycines”, Nature Commun.202011, 5935. DOI: 10.1038/s41467-020-19807-5.

    (5) Mo Wang, Lu Zhang, Xiaohong Huo, Zhenfeng Zhang, Qianjia Yuan, Panpan Li, Jianzhong Chen, Yashi Zou, Zhengxing Wu, and Wanbin Zhang*, “Catalytic Asymmetric Synthesis of the Anti-COVID-19 Drug Remdesivir”, Angew. Chem. Int. Ed., 202059, 20814-20819. DOI: 10.1002/anie.202011527.

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    (6) Yawen Hu, Jianzhong Chen, Bowen Li, Zhenfeng Zhang, Ilya D. Gridnev, and Wanbin Zhang*, "Nickel-Catalyzed Asymmetric Hydrogenation of 2-Amidoacrylates", Angew. Chem. Int. Ed., 202059, 5371-5375.

    (7) Jianzhong Chen, Feilong Li, Fang Wang, Yawen Hu, Zhenfeng Zhang, Min Zhao*, and Wanbin Zhang*, "Pd(OAc)2-Catalyzed Asymmetric Hydrogenation of α-Iminoesters", Org. Lett., 201921, 9060-9065.

    (8) Bowen Li, Jianzhong Chen, Zhenfeng Zhang, Ilya D. Gridnev, and Wanbin Zhang*, (VIP): "Ni-Catalyzed Asymmetric Hydrogenation of N-Sulfonyl Imines", Angew. Chem. Int. Ed., 201958, 7329-7334. Cover Picture: DOI: 10.1002/anie.201905441.

    (9) Jianzhong Chen, Zhenfeng Zhang, Bowen Li, Feilong Li, Yulin Wang, Min Zhao, Ilya D. Gridnev, Tsuneo Imamoto and Wanbin Zhang*, "Pd(OAc)2-catalyzed asymmetric hydrogenation of sterically hindered N-tosylimines", Nature Commun., 20189, 5000.

    (10) Jianzhong Chen, Zhenfeng Zhang, Delong Liu, and Wanbin Zhang*, “Palladium-Catalyzed Chemo- and Enantioselective C-O Bond Cleavage of a-Acyloxy Ketones via Hydrogenolysis”, Angew. Chem. Int. Ed., 201655, 8444-8447.

    (11) Jianzhong Chen, Delong Liu, Dongyang Fan, Yangang Liu, and Wanbin Zhang*, “Synthesis of Axially Chiral C10-BridgePHOS Oxides and Their Use as Organocatalysts in Enantioselective Allylations of Aldehydes”, Tetrahedron 201369, 8161-8168.

    (12) Jianzhong Chen, Delong Liu, Nicholas Butt, Chao Li, Dongyang Fan, Yangang Liu, and Wanbin Zhang*, “Palladium-Catalyzed Asymmetric Hydrogenation of a-Acyloxy-1-aryletheanones”, Angew. Chem. Int. Ed.201352, 11632-11636.

  • 荣誉奖励

    2016年度横山亮次教师优秀论文奖

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电话:021-54742893
E-mail:sjtuscce@sjtu.edu.cn

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