Shuyu ZHANGProfessor

Email: zhangsy16@sjtu.edu.cn 
Address: B329 Chemistry Building, 800 Dongchuan Road. 
Home Page: (CH): https://scce.sjtu.edu.cn/teachers/1399.html 

Educational Background

1998-2002  B.S. Chemistry, Lanzhou University, P. R. China.
2005-2010  Ph.D. Organic Chemistry, Lanzhou University, P. R. China.

Work Experience

2002-2010  State Key Laboratory of Applied Organic Chemistry
2010-2011  Postdoctor, Department of Chemistry, The University of Chicago, USA.
2011-2014  Postdoctor, Department of Chemistry, Penn State University, USA.
2015-2020  Tenure Track Associate Professor, Shanghai Jiao Tong University, China
2021-2021  Tenured Associate Professor, Shanghai Jiao Tong University, China
2022-          Professor, Shanghai Jiao Tong University, China


Research Interests

1) Collective total synthesis of natural products and active drug molecules with unactived C-H bond activation as the key step;

2) Axially Chiral Styrene chemistry, electrochemical rearrangement reaction, asymmetric C-N bond construction reaction and computational chemistry;

3) Fluorescent probes combined with chemical biology, biomimetic synthesis, and synthetic biology research.

Research Project

We thank the National Key Research & Development Program of China (2021YFF0701800 and 2022YFC2703400), the Fundamental Research Funds for the Central Universities (YG2022ZD021), NSFC (No. 22071147), and STCSM (22ZR1435100).


Recent Publications:

1) How achiral Brønsted acid involves in co-catalyst model with chiral phosphoric acid for construction of quaternary carbon stereocenter
Zi-Hao Li,  Jia Zhou, Chang Liu, Fu-Xin Tan, Le Wang, Guo-Dong Zhu, Shu-Yu Zhang*
Chem Catal. 20244, 100918.

2) Cooperative Cu/azodiformate system-catalyzed allylic C–H amination of unactivated internal alkenes directed by aminoquinoline
Le WangCheng-Long WangZi-Hao LiPeng-Fei LianJun-Chen KangJia ZhouYu HaoRu-Xin LiuHe-Yuan Bai, Shu-Yu Zhang*
Nature Commun. 202415, 1483.

3) Asymmetric Intramolecular Hydroalkylation of Internal Olefin with Cycloalkanone to Directly Access Polycyclic Systems
Ai-Fang WangJin-Miao TianXiao-Jing ZhaoZi-Hao LiYe ZhangKa LuHong WangShu-Yu Zhang,* Yong-Qiang Tu,* Tong-Mei DingYu-Yang Xie
Angew Chem. Int. Ed. 202362e202308858.

4) Axially Chiral Styrene-Based Organocatalysts and Their Application in Asymmetric Cascade Michael/Cyclization Reaction
Yu Hao, Zi-Hao Li, Zhi-Gang Ma, Ru-Xin Liu, Rui-Tian Ge, Quan-Zhe Li, Tong-Mei Ding, and 
Shu-Yu Zhang*
Chem. Sci. 2023, 9496.

5) Electroreductive fluoroalkylative heteroarylationof unactivated alkenes via an unconventionalremote heteroaryl migration
Chao Chen, Shen-Yuan Zhang, Shuai-Xin Li, Zi-Hao Li, Ru-Xin Liu, Jun-Chen Kang, Tong-Mei Ding, and Shu-Yu Zhang*
Cell Rep. Phys. Sci. 20234, 101385.

6) Synthetic strategies and mechanistic studies of axially chiral styrenes
Zi-Hao LiQuan-Zhe LiHe-Yuan BaiShu-Yu Zhang*
Chem Catal. 2023, 3, 100594.

7) Bioinspired Palladium-Catalyzed Intramolecular C(sp3)−H Activation for the Collective Synthesis of Proline Natural Products
Quan-Zhe Li,
 Si-Hua Hou, Jun-Chen Kang, Peng-Fei Lian, Yu Hao, Chao Chen, Jia Zhou, Tong-Mei Ding and Shu-Yu Zhang*
Angew Chem. Int. Ed. 202261e202207088.

8) Molecular basis for cell-wall recycling regulation by transcriptional repressor MurR in Escherichia coli
Ya Zhang#, Weizhong Chen#, Di Wu#, Yushi Liu, Zhaowei Wu, Jian Li, 
Shu-Yu Zhang,* and Quanjiang Ji*
Nucleic Acids Research2022,.50, 5948.

9) CPA-Catalyzed Enantioselective Dearomative Electrophilic Hy-drazination : Access to Chiral Aza-Quaternary Carbon Indolenines
Xin-Yue Qiu, Zi-Hao Li, Jia Zhou, Peng-Fei Lian, Li-Kun Dong, Tong-Mei Ding, He-Yuan Bai, and Shu-Yu Zhang*
ACS Catal. 2022

10) Ni-Catalyzed, Enantioselective Three-component Radical Relayed Reductive Coupling of Alkynes: Synthesis of Axially Chiral Styrenes
Quan-Zhe Li, Zi-Hao Li, Jun-Chen Kang, Tong-Mei Ding, and Shu-Yu Zhang*
Chem Catal. 2022, 2, 3185.

More Publications





Undergraduate: Organometallic Chemistry, Zhiyuan College

Graduate students:  Advanced Organic Chemistry,Organometallic Chemistry

Undergraduate students projects: Dachuang Project, Zhiyuan Scholars Project, CURE Scholars Project.

Part-time Academic Job

Journal of Shanghai Jiao Tong University, Young editorial member

Honors and Awards

2022: The First Prize of National Teaching Achievement Award (R6)

2021: Teaching and Educating Award, Shanghai Jiao Tong University

2021: Thieme Chemistry Journals Award

2016: Shanghai Shuguang Scholar

2016: The 2nd Prize of National Natural Science Award (R5)

2015: The First Prize of Natural Science Award of Ministry of Education (R5)

Open Positions

Research Opportunities
We  are always looking to recruit talented and committed scientists. If you  are interested in working in our group, please feel free to contact me  anytime.

Postdoctoral Positions
Postdoctoral position available at: (http://join.sjtu.edu.cn/ZPSpecialShow.aspx?id=510). Candidates must possess a PhD, less than 35 years old, and strong research skills and background in total synthesis, catalytic asymmetric, or organometallic chemistry.  

Ph.D. Positions
PhD positions are available in our group two times each year, usually starting in April or September. For international students, see: http://isc.sjtu.edu.cn (Application periodDec.  1-Apr. 30). If you are interested in a PhD with our group, please  contact me and send your CV and Statement to zhangsy16@sjtu.edu.cn  anytime.   

Master Positions
M.S. positions are available in our group every year. Our master's program (School of Chemistry and Chemical Engineering) needs to be taught in Chinese, and applicants for the Master's program need to have a Chinese language level of HSK Level 5 or above (200,60)If you are interested in a M.S. with our group, please  contact me and send your CV, Chinese proficiency certificate, and Statement to zhangsy16@sjtu.edu.cn  anytime.  

Address:800 Dongchuan RD. Minhang District, Shanghai, China
PostCode:200240 Tel:021-54742893 E-mail:sjtuscce@sjtu.edu.cn


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