1998-2002  B.S. Chemistry, Lanzhou University, P. R. China.
2005-2010  Ph.D. Organic Chemistry, Lanzhou University, P. R. China.   

2002-2010  State Key Laboratory of Applied Organic Chemistry
2010-2011  Postdoctor, Department of Chemistry, The University of Chicago, USA.
2011-2014  Postdoctor, Department of Chemistry, Penn State University, USA.
2015-2020  Tenure Track Associate Professor, Shanghai Jiao Tong University, China
2021-2021  Tenured Associate Professor, Shanghai Jiao Tong University, China
2022-          Professor, Shanghai Jiao Tong University, China

1) Collective total synthesis of natural products and active drug molecules with unactived C-H bond activation as the key step;

2) Axially Chiral Styrene chemistry, electrochemical rearrangement reaction, asymmetric C-N bond construction reaction and computational chemistry;

3) Fluorescent probes combined with chemical biology, biomimetic synthesis, and synthetic biology research.

We thank the National Key Research & Development Program of China (2021YFF0701800 and 2022YFC2703400), the Fundamental Research Funds for the Central Universities (YG2022ZD021), NSFC (No. 22071147), and STCSM (22ZR1435100).

Recent Publications：

1) Indocyanine polymethine fluorophores with extended π-conjugation emitting beyond 1,200 nm for enhanced NIR-II imaging

Rui-Tian Ge, Feng Xiong, Zhen Bang Chen, Yuanjie Wang, Lin Zheng, Jia Zhou, Di Wu*, Shu-Yu Zhang*
Chem, 2025, 11, 102489.

2) Allylic C–H oxygenation of unactivated internal olefins by the Cu/azodiformate catalyst system
Le Wang, Yuan She, Jie Xiao, Zi-Hao Li, Shen-Yuan Zhang, Peng-Fei Lian, Tong-Mei Ding, Shu-Yu Zhang*
Nature Commun. 2025, 16, 875.

3) Machine learning for active sites prediction of quinoline derivatives
Jie Sun, Zi-Hao Li, * Yi-Fei Yang, Shu-Yu Zhang*
Artificial Intelligence Chemistry, 2025, 100082.

4) Organocatalytic asymmetric tandem reaction for the enantioselective synthesis of chiral oxindoles to construct CyK dyes
Le Wang, Zi-Hao Li, Di Wu, Rui-Tian Ge, Jia Zhou, Yin-Feng Zhang, Shu-Yu Zhang*
Chem Catal. 2025, 5, 101188.

5) Organocatalytic Asymmetric Synthesis of Sulfonyl-Substituted Furans via a Cascade 1,6-Addition/Cyclization/Enantioselective Protonation Pathway
Peng-Fei Lian, Zi-Hao Li*, Xin-Yue Qiu, Tong-Mei Ding, Shu-Yu Zhang*
ACS Catal. 2024, 14, 12717.

6) Asymmetric Intramolecular Amination Catalyzed with Cp*Ir-SPDO via Nitrene Transfer for Synthesis of Spiro-Quaternary Indolinone
Shi-Qiang Wei, Zi-Hao Li, Shuang-Hu Wang, Hua Chen, Xiao-Yu Wang, Yun-Zhou Gu, Ye Zhang, Hong Wang, Tong-Mei Ding, Shu-Yu Zhang,* Yong-Qiang Tu*
J. Am. Chem. Soc. 2024, 146, 18841.

7) Enantioselective sequential Michael addition/C-H olefination/Michael reaction for the efficient collective synthesis of clavine alkaloids
Zhi-Gang Ma,^† Yu Hao,^† Wei Jiang, Xian-Yu Pan, Tong-Mei Ding, Si-Hua Hou, Shu-Yu Zhang*
Cell Rep. Phys. Sci. 2024, 102112.

8) How achiral Brønsted acid involves in co-catalyst model with chiral phosphoric acid for construction of quaternary carbon stereocenter
Zi-Hao Li,^†  Jia Zhou,^† Chang Liu, Fu-Xin Tan, Le Wang, Guo-Dong Zhu, Shu-Yu Zhang*
Chem Catal. 2024, 4, 100918.

9) Cooperative Cu/azodiformate system-catalyzed allylic C–H amination of unactivated internal alkenes directed by aminoquinoline
Le Wang, Cheng-Long Wang, Zi-Hao Li, Peng-Fei Lian, Jun-Chen Kang, Jia Zhou, Yu Hao, Ru-Xin Liu, He-Yuan Bai, Shu-Yu Zhang*
Nature Commun. 2024, 15, 1483.

10) Asymmetric Intramolecular Hydroalkylation of Internal Olefin with Cycloalkanone to Directly Access Polycyclic Systems
Ai-Fang Wang, Jin-Miao Tian, Xiao-Jing Zhao, Zi-Hao Li, Ye Zhang, Ka Lu, Hong Wang, Shu-Yu Zhang,* Yong-Qiang Tu,* Tong-Mei Ding, Yu-Yang Xie
Angew Chem. Int. Ed. 2023, 62, e202308858.

11) Axially Chiral Styrene-Based Organocatalysts and Their Application in Asymmetric Cascade Michael/Cyclization Reaction
Yu Hao, Zi-Hao Li, Zhi-Gang Ma, Ru-Xin Liu, Rui-Tian Ge, Quan-Zhe Li, Tong-Mei Ding, and Shu-Yu Zhang*
Chem. Sci. 2023, 9496.

12) Electroreductive fluoroalkylative heteroarylationof unactivated alkenes via an unconventionalremote heteroaryl migration
Chao Chen, Shen-Yuan Zhang, Shuai-Xin Li, Zi-Hao Li, Ru-Xin Liu, Jun-Chen Kang, Tong-Mei Ding, and Shu-Yu Zhang*
Cell Rep. Phys. Sci. 2023, 4, 101385.

13) Synthetic strategies and mechanistic studies of axially chiral styrenes
Zi-Hao Li, Quan-Zhe Li, He-Yuan Bai, Shu-Yu Zhang*
Chem Catal. 2023, 3, 100594.

14) Bioinspired Palladium-Catalyzed Intramolecular C(sp3)−H Activation for the Collective Synthesis of Proline Natural Products
Quan-Zhe Li,^† Si-Hua Hou,^† Jun-Chen Kang, Peng-Fei Lian, Yu Hao, Chao Chen, Jia Zhou, Tong-Mei Ding and Shu-Yu Zhang*
Angew Chem. Int. Ed. 2022, 61, e202207088.

15) Molecular basis for cell-wall recycling regulation by transcriptional repressor MurR in Escherichia coli
Ya Zhang#, Weizhong Chen#, Di Wu#, Yushi Liu, Zhaowei Wu, Jian Li, Shu-Yu Zhang,* and Quanjiang Ji*
Nucleic Acids Research, 2022, 50, 5948.

16) CPA-Catalyzed Enantioselective Dearomative Electrophilic Hy-drazination : Access to Chiral Aza-Quaternary Carbon Indolenines
Xin-Yue Qiu, Zi-Hao Li, Jia Zhou, Peng-Fei Lian, Li-Kun Dong, Tong-Mei Ding, He-Yuan Bai, and Shu-Yu Zhang*
ACS Catal. 2022, 12, 7511.

17) Ni-Catalyzed, Enantioselective Three-component Radical Relayed Reductive Coupling of Alkynes: Synthesis of Axially Chiral Styrenes
Quan-Zhe Li, Zi-Hao Li, Jun-Chen Kang, Tong-Mei Ding, and Shu-Yu Zhang*
Chem Catal. 2022, 2, 3185.

More Publications：

https://orcid.org/0000-0002-1811-4159

ResearchGate

https://www.scholarmate.com/P/v2ER3e?module=pub

Undergraduate: Organometallic Chemistry, Zhiyuan College

Graduate students: Advanced Organic Chemistry，Organometallic Chemistry

Undergraduate students projects: Dachuang Project, Zhiyuan Scholars Project, CURE Scholars Project.

Scholarship of teaching and learning, SoTL

1) Using Computational Chemistry to Improve Students' Multidimensional Understanding of Complex Electrophilic Aromatic Substitution Reactions: Further Analysis of the Solvent Effect, Temperature Influence, and Kinetic Behaviors
Li-Kun Dong, Zi-Hao Li, Shu-Yu Zhang*
J. Chem. Educ. 2021, 98, 3226-3236.

2) Project-Based Learning in Green Electrochemistry for Undergraduates: An Efficient Synthesis Route of Natural Product
Ru-Xin Liu, Feng Xiong, Chao Chen, Tong-Mei Ding, Shu-Yu Zhang*
J. Chem. Educ. 2023, 100, 689-696.

3) Bringing Green Organic Electrochemistry to Undergraduates: A Designed Comparison Organic Experiment of Bromination
Feng Xiong, Ru-Xin Liu, Xiao-Xuan Fan, Min Zhang, Yuan She, Wei-Qing Cao, Chao Chen, Tong-Mei Ding, and Shu-Yu Zhang*
J. Chem. Educ. 2023, 100, 4686-4695.

4) Using Computational Chemistry to Compare the Strength of Lewis Bases from HOMO Orbital Energy
Xin-Yu Chen, Zi-Hao Li,* Li-Kun Dong, Xie-Yang Jiang, and Shu-Yu Zhang*
Chin. J. Chem. Educ. 2024, 45, 38-44.

5) Stepwise or Concerted Mechanisms? Rethinking of the Classical Carbocation Rearrangement Reaction
Qing-Yun Cai, Hao Zheng, Zi-Hao Li, Li-Kun Dong, Jia Zhou, and Shu-Yu Zhang*
J. Chem. Educ. 2024, 101, 5068-5076.

Journal of Shanghai Jiao Tong University, Young editorial member

2022: The First Prize of National Teaching Achievement Award (R6)

2021: Teaching and Educating Award, Shanghai Jiao Tong University

2021: Thieme Chemistry Journals Award

2016: Shanghai Shuguang Scholar

2016: The 2nd Prize of National Natural Science Award (R5)

2015: The First Prize of Natural Science Award of Ministry of Education (R5)

Research Opportunities
We  are always looking to recruit talented and committed scientists. If you  are interested in working in our group, please feel free to contact me  anytime.

Postdoctoral Positions
Postdoctoral position available at: (http://join.sjtu.edu.cn/ZPSpecialShow.aspx?id=510). Candidates must possess a PhD, less than 35 years old, and strong research skills and background in total synthesis, catalytic asymmetric, or organometallic chemistry.  

Ph.D. Positions
PhD positions are available in our group two times each year, usually starting in April or September. For international students, see: http://isc.sjtu.edu.cn (Application period：Dec.  1-Apr. 30). If you are interested in a PhD with our group, please  contact me and send your CV and Statement to zhangsy16@sjtu.edu.cn  anytime.   

Master Positions
M.S. positions are available in our group every year. Our master's program (School of Chemistry and Chemical Engineering) needs to be taught in Chinese, and applicants for the Master's program need to have a Chinese language level