Faculty

Gang CHENTenure-track Associate Professor

Email: gchen2018@sjtu.edu.cn 
Address: 上海市闵行区东川路800号上海交通大学化学化工学院 

Educational Background

2007.9 – 2012.6:      Ph.D. in Organic Chemistry      Prof. Chengye Yuan and Dawei Ma
        State Key Laboratory of Bio-organic Chemistry, Shanghai Institute of Organic
        Chemistry (SIOC), Chinese Academy of Sciences (CAS), Shanghai, P. R. China
2003.9 – 2007.7:       B.S. in Chemistry      Prof. Yuhua Ge
         Southeast University, Nanjing, P. R. China

Work Experience

2018.09-:                   Associate Professor
                                  School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University,
                                  Shanghai, P. R. China

2017.10-2018.08:      Postdoc                        Prof.  Mike Petrassi, Peter Schultz         
                                 Medical Chemistry Department, The California Institute for Biomedical Research  
                                  (Calibr), La Jolla, USA

2013.02 – 2017.10:      Research Associate      Prof. Jin-Quan Yu
        Department of Chemistry, The Scripps Research Institute (TSRI), La Jolla, USA

2012.07 – 2013.02:      Research Associate      Prof. Chengye Yuan and Dawei Ma
        State Key Laboratory of Bio-organic Chemistry, Shanghai Institute of Organic
        Chemistry (SIOC), Chinese Academy of Sciences (CAS), Shanghai, P. R. China

Research Interests

My Group will focus on the natural product targeting the immune-system, especially total syntheses of natural products by newly developed methodology.

Research Themes:
1. Total synthesis of nature products.
2. Medicinal chemistry and chemical biology of immune-therapy

Publications

1. Gang Chen‡, Wei Gong‡, Zhe Zhuang, Michal S. Andra, Yan-Qiao Chen, Xin Hong, Yun-Fang Yang, Tao Liu, K. N. Houk*, Jin-Quan Yu*. "Ligand-Accelerated Enantioselective Methylene C(sp3)-H Bond Activation" Science 2016, 353, 1023. (Highlighted on C&EN News and Cell Chemistry) (‡ Co-first author)
2. Gang Chen, Toshihiko Shigenari, Pankaj Jain, Zhipeng Zhang, Zhong Jin, Jian He, Suhua Li, Claudio Mapelli, Michael M. Miller, Michael A. Poss, Paul M. Scola, Kap-Sun Yeung, Jin-Quan Yu*. "Ligand-Enabled beta-C-H Arylation of alpha-Amino Acids Using a Simple and Practical Auxiliary" J. Am. Chem. Soc. 2015, 137, 3338.
3. Gang Chen, Zhe Zhuang, Gen-Cheng Li, Tyler G. Saint-Denis, Yi Xiao, Candice L. Joe, Jin-Quan Yu*. "Ligand-Enabled β-C–H Arylation of α-Amino Acids without Installing Exogenous Directing Groups" Angew. Chem. Int. Ed. 2017, 56, 1506.
4. Yun-Fang Yang, Gang Chen, Xin Hong, Jin-Quan Yu, K. N. Houk. "The Origins of Dramatic Differences in Five-Membered vs Six-Membered Chelation of Pd(II) on Efficiency of C(sp3)-H Bond Activation" J. Am. Chem. Soc. 2017, 139, 8514.
5. Suhua Li, Gang Chen, Chen-Guo Feng, Wei Gong, Jin-Quan Yu*. "Ligand-enabled gamma-C-H Olefination and Carbonylation: Construction of beta-Quaternary Carbon Centers" J. Am. Chem. Soc. 2014, 136, 5267.
6. Dajian Zhu, Guoqiang Yang, Jian He, Ling Chu, Gang Chen, Wei Gong, Ke Chen, Martin D. Eastgate, Jin-Quan Yu*. "Ligand-Promoted ortho-C-H Amination with Pd Catalysts" Angew. Chem. Int. Ed. 2015, 54, 2497.
7. Jian He, Heng Jiang, Ryosuke Takise, Ru-Yi Zhu, Gang Chen, Hui-Xiong Dai, T. G. Murali Dhar, Jun Shi, Hao Zhang, Peter T. W. Cheng, Jin-Quan Yu*. "Ligand-Promoted Borylation of C(sp3)-H Bonds with Pd(II) Catalysts." Angew. Chem. Int. Ed. 2016, 55, 785.
8. Kai-Jiong Xiao, Ling Chu, Gang Chen, Jin-Quan Yu. "Kinetic Resolution of Benzylamines via Palladium(II)-Catalyzed C-H Cross-Coupling" J. Am. Chem. Soc. 2016, 138, 7796.
9. Gang Chen, Hongguang Xia, Yu Cai, Dawei Ma*, Junying Yuan*, Chengye Yuan*. "Diphenylbutylpiperidine-based cell autophagy inducers: Design, synthesis and SAR studies". MedChemCommun, 2011, 2, 315.
10. Gang Chen, Hongguang Xia, Yu Cai, Dawei Ma*, Junying Yuan*, Chengye Yuan*. "Synthesis and SAR study of diphenylbutylpiperidines as cell autophagy inducers". Bioorg. Med. Chem. Lett., 2011, 21, 234.
11. Hong-Guang Xia, Lihong Zhang, Gang Chen, Tao Zhang, Junli Liu, Mingzhi Jin, Xiuquan Ma, Dawei Ma*, Junying Yuan*. "Control of basal autophagy by calpain1 mediated cleavage of ATG5". Autophagy, 2010, 6, 1.

PATENTS
1. Junying Yuan*, Chengye Yuan*, Gang Chen, Hongguang Xia. “Diphenylbutylpiperidines autophagy inducers.” WO2011143444 (A2).
2. Gang Chen, Dawei Ma*, Junying Yuan*, Chengye Yuan*. “Diphenylalkyl halide or diphenyl carboxylic acid and synthesis method thereof.” Chinese patent. CN101948368B.

Honors and Awards

2018: "The Thousand Talents Plan" Young Outstanding Scholarship

Address:800 Dongchuan RD. Minhang District, Shanghai, China
PostCode:200240 Tel:021-54742893 E-mail:sjtuscce@sjtu.edu.cn

Wechat

Copyright@ 2023. All rights reserved. Powered by SCCE ICP:2010917