Chunhai Fan obtained his B.S. and Ph.D. from the Department of Biochemistry at Nanjing University in 1996 and 2000. After his postdoctoral research at University of California, Santa Barbara (UCSB), he joined the faculty at Shanghai Institute of Applied Physics (SINAP), Chinese Academy of Sciences (CAS) in 2004, where he holds a position of CAS Distinguished Professor at SINAP. Since 2018, he is a K. C. Wong Chair Professor, New Cornerstone Investigator and Dean in the School of Chemistry and Chemical Engineering at Shanghai Jiao Tong University (SJTU), and Executive Dean of the National Center for Translational Medicine.

Nucleic acids chemistry, molecular machines, DNA nanotechnology, DNA computing and storage, biosensors and bioimaging

1.     H. Lv, N. Xie, M. Li, M. Dong, C. Sun, Q. Zhang, L. Zhao, J. Li, X. Zhao, H. Chen, F. Wang, C. Fan, DNA-based programmable gate arrays for general-purpose DNA computing. Nature 622, 292 (2023).

2.     Y. Zhao, S. Cao, Y. Wang, F. Li, L. Lin, L. Guo, F. Wang, J. Chao, X. Zuo, Y. Zhu, L. Wang, J. Li, C. Fan, A temporally resolved DNA framework state machine in living cells. Nature Machine Intelligence 5, 980 (2023).

3.     F. Yin, H. Zhao, S. Lu, J. Shen, M. Li, X. Mao, F. Li, J. Shi, J. Li, B. Dong, W. Xue, X. Zuo, X. Yang, C. Fan, DNA-framework-based multidimensional molecular classifiers for cancer diagnosis. Nature Nanotechnol. 18, 677 (2023).

4.     J. Liu, X. Jin, M. Liu, F. Li, M. Li, Q. Li, J. Shi, J. Li, L. Wang, X. Mao, X. Zuo, C. Fan, Mechano-fluorescence actuation in single synaptic vesicles with a DNA framework nanomachine. Science Robotics 7, eabq5151(2022).

5.     G. Yao, J. Li, Q. Li, X. Chen, X. Liu, F. Wang, Z. Qu, Z. Ge, R. P. Narayanan, D. Williams, H. Pei, X. Zuo, L. Wang, H. Yan, B. L. Feringa, C. Fan, Programming nanoparticle valence bonds with single-stranded DNA encoders. Nature Mater. 19, 781 (2020).

6.     G. Yao, F. Zhang, F. Wang, T. Peng, H. Liu, E. Poppleton, P. Sulc, S. Jiang, L. Liu, C. Gong, X. Jing, X. Liu, L. Wang, Y. Liu, C. Fan, H. Yan, Meta-DNA structures. Nature Chem. 12, 1067 (2020).

7.     J. Chao, J. Wang, F. Wang, X. Ouyang, E. Kopperger, H. Liu, Q. Li, J. Shi, L. Wang, J. Hu, L. Wang, W. Huang, F. C. Simmel, C. Fan, Solving mazes with single-molecule DNA navigators. Nature Mater. 18, 273 (2019).

8.     X. Liu, F. Zhang, X. Jing, M. Pan, P. Liu, W. Li, B. Zhu, J. Li, H. Chen, L. Wang, J. Lin, Y. Liu, D. Zhao, H. Yan, C. Fan, Complex silica composite nanomaterials templated with DNA origami. Nature 559, 593 (2018).

9.     D. Jiang, Z. Ge, H.-J. Im, C. G. England, D. Ni, J. Hou, L. Zhang, C. J. Kutyreff, Y. Yan, Y. Liu, S. Y. Cho, J. W. Engle, J. Shi, P. Huang, C. Fan, H. Yan, W. Cai, DNA origami nanostructures can exhibit preferential renal uptake and alleviate acute kidney injury. Nature Biomed. Eng. 2, 865 (2018).

10.  J. Li, A. A. Green, H. Yan, C. Fan, Engineering nucleic acid structures for programmable molecular circuitry and intracellular biocomputation. Nature Chem. 9, 1056 (2017).

Dr. Fan is a member of the Chinese Academy of Sciences (CAS academician), a member of the Chinese Academy of Medical Sciences, a fellow of American Association for the Advancement of Science (AAAS), Royal Society of Chemistry (FRSC), American Institute of Medical and biological Engineering (AIMBE) and International Society of Electrochemistry (ISE). He is an Associate Editor of JACS-Au, and serves as a Co-Chair on the editorial board of ChemPlusChem and an editorial board member of over 10 journals including Angewadte Chemie, Accounts of Chemical Research and ACS Nano. Dr. Fan has published more than 700 papers in peer-reviewed journals (with ~80, 000 citations and H-index 138), and been recognized as Highly Cited Researchers by Clarivate Analytics since 2014. His work has been recognized by many awards including National Natural Science Prize of China (2016), National Award for Young Scientists of China (2011), The Ho Leung Ho Lee Foundation Prize for Scientific and Technological Innovation (2019), Advances in Measurement Science Lectureship Award in American Chemical Society (2019), WuXi AppTech Life Science and Chemistry Award (2020) and JNB Trailblazer (2021).