Principal Investigator, Mar 2016-Present
• Synthesis of complex oligosaccharides, natural products, peptides, glycoproteins
• Chemical Biology
• Drug Discovery

 

Education 

Ph. D., Organic chemistry, 2005，Shanghai Institute of Organic chemistry, Chinese Academy of Sciences, (Advisor Biao Yu)
B.A., Chemistry, 2000，Nanjing University

 

Experience
      Warp Drive Bio, Cambridge, MA, U.S.A
            Scientist, Jan 2014-Feb 2016
• Designed and developed K-RAS inhibitors for cancer treatment

      Memorial Sloan Kettering Cancer Center, New York, NY, U.S.A
           Senior Research Scientist, Research Associate (Advisor Samuel J. Danishefsky), 
           Apr 2008-Dec 2013            
• Synthesis of IgG1 Fc fragment
• Study of ligating polypeptides from thioacids and amines
• Synthesis of homogeneous erythropoietin

      The Burnham Institute for Medical Research , La Jolla, CA, U.S.A
            Research Associate (Advisor Peter H. Seeberger), Oct 2005-Mar 2008
• Synthesis of oligosaccharides containing 1,4- GlcNAc capping structure with antibiotic activity against Helicobacter pylori

 

Publications

1.       Wang, S.; Zhou, Q.; Chen, X.; Luo, R.-H.; Li, Y.; Liu, X.; Yang, L.-M.; Zheng, Y.-T.; Wang, P., Modification of N-Terminal α-Amine of Proteins via Biomimetic ortho-quinone-mediated Oxidation. Nat. Commun. 2021, 10.1038/s41467-021-22654-7.

2.       Ye, F.; Zhao, J.; Xu, P.; Liu, X.; Yu, J.; Shangguan, W.; Liu, J.; Luo, X.; Li, C.; Ying, T.; Wang, J.; Yu, B.; Wang, P., Synthetic Homogeneous Glycoforms of the SARS-CoV-2 Spike Receptor-Binding Domain Reveals Different Binding Profiles of Monoclonal Antibodies. Angew. Chem. Int. Ed. 2021, doi.org/10.1002/ anie.202100543.

3.       Li, Y.; Liu, J.; Zhou, Q.; Zhao, J.; Wang, P., The preparation of peptide selenoesters from their corresponding acyl hydrazides. Chin. J. Chem. 2021, doi.org/10.1002/cjoc.202100086. Invited Article.

4.       Yin, H.;  Zheng, M.;  Chen, H.;  Wang, S.;  Zhou, Q.;  Zhang, Q.; Wang, P., Stereoselective and Divergent Construction of β-Thiolated/Selenolated Amino Acids via Photoredox-Catalyzed Asymmetric Giese Reaction. J. Am. Chem. Soc. 2020, 142, 14201-14209.

5.       Chen, X.;  Luo, X.;  Peng, X.;  Guo, J.;  Zai, J.; Wang, P., Catalyst-Free Decarboxylation of Carboxylic Acids and Deoxygenation of Alcohols by Electro-Induced Radical Formation. Chem. Eur. J. 2020, 26, 3226- 3230.

6.       Chen, X.;  Luo, X.;  Wang, K.;  Liang, F.; Wang, P., Late-Stage Alkylation of N-Containing Heteroarenes Enabled by Homolysis of Alkyl-1,4-dihydropyridines under Blue LED Irradiation. Synlett 2020, 31, A-E.

7.       Lu, D.;  Wang, S.;  Yin, H.;  Chu, F.;  Wei, Q.; Wang, P., Rapid Assembly of Oligosaccharides by Using a Hydrophobic Tag-Assisted Liquid-Phase Method. Synlett 2020, 31, 1163-1166.

8.       Lu, D.;  Yin, H.;  Wang, S.;  Tang, F.;  Huang, W.; Wang, P., Chemical Synthesis of the Homogeneous Granulocyte-Macrophage Colony-Stimulating Factor Through Se-Auxiliary-Mediated Ligation. J. Org. Chem. 2020, 85, 1652-1660. Invited Article.

9.       Chen, X.;  Ye, F.;  Luo, X.;  Liu, X.;  Zhao, J.;  Wang, S.;  Zhou, Q.;  Chen, G.; Wang, P., Histidine-Specific Peptide Modification via Visible-Light-Promoted C–H Alkylation. J. Am. Chem. Soc. 2019, 141, 18230-18237.

10.     Liu, X.;  Liu, J.;  Wu, Z.;  Chen, L.;  Wang, S.; Wang, P., Photo-cleavable purification/protection handle assisted synthesis of giant modified proteins with tandem repeats. Chem. Sci. 2019, 10, 8694-8700.

11.     Wang, K.;  Chen, X.;  Peng, X.;  Wang, P.; Liang, F., A highly selective H/D exchange reaction of 1,4-dihydropyridines. Org. Biomol. Chem. 2019, 17, 3845-3852.

12.     Wang, S.;  Thopate, Y. A.;  Zhou, Q.; Wang, P., Chemical Protein Synthesis by Native Chemical Ligation and Variations Thereof. Chin. J. Chem. 2019, 37, 1181-1193. Invited review.

13.     Ye, J.;  Xia, H.;  Sun, N.;  Liu, C.-C.;  Sheng, A.;  Chi, L.;  Liu, X.-W.;  Gu, G.;  Wang, S.-Q.;  Zhao, J.;  Wang, P.;  Xiao, M.;  Wang, F.; Cao, H., Reprogramming the enzymatic assembly line for site-specific fucosylation. Nat. Catal. 2019, 2, 514-522.

14.     Yin, H.;  Lu, D.;  Wang, S.; Wang, P., Development of Powerful Auxiliary-Mediated Ligation To Facilitate Rapid Protein Assembly. Org. Lett. 2019, 21, 5138-5142.

15.     Luo, H.;  Yin, H.;  Tang, C.;  Wang, P.; Liang, F., Synthesis of cyclic peptide reniochalistatin E and conformational isomers. Chin. Chem. Lett. 2018, 29, 1143-1146.

Before 2018

16.     Ping Wang, Suwei Dong, Jaehung Shieh, Ronald C. Hendrickson, Malcolm A. Moore, Samuel J. Danishefsky. Erythropoietin Derived by Chemical Synthesis. Science. 2013, 342, 1357-1360.

17.     Rebecca M. Wilson, Suwei Dong, Ping Wang and Samuel J. Danishefsky. The Winding Pathway to Erythropoietin: Success At Last, Angew. Chem. Int. Ed. 2013, 52.

18.     Xiaoyu Yang, Ping Wang, Biao Yu. Tacking the challenges in the Total Synthesis of Landomycin A. The Chemical Record. 2013, 13, 70-84.

19.     Ping Wang, Suwei Dong, Karthik Iyer, John A. Brailsford, Steve D. Townsend, Qiang Zhang, Ronald C. Hendrickson, Jaehung Shieh, Malcolm A. Moore, Samuel J. Danishefsky. At Last: Erythropoietin as a Single Glycoform. Angew. Chem. Int. Ed. 2012, 51, 11576–11584. (Cover of the Journal, Highlighted by Science, Nature, Angew. Chem. Int. Ed., Chemistry World, Chemistry Views, C&EN NEWS)

20.     Ping Wang, Baptiste Aussedat, Yusuf Vohra and Samuel J. Danishefsky. An Advance in the Chemical Synthesis of Homogeneous N-Linked Glycopolypeptides by Convergent Aspartylation. Angew. Chem. Int. Ed. 2012, 51, 11571–11575.

21.     Rebecca M. Wilson, Jennifer L. Stockdill, Paul A. Vadola, Xiangyang Wu, Xuechen Li, Peter Park, Ping Wang and Samuel J. Danishefsky. A Journey into History: Exploration of the Fascinating World of Isonitriles. Angew. Chem. Int. Ed. 2012, 51, 2–17.

22.     Toshiaki K. Shibata, Fumiko Matsumura, Ping Wang, ShinYi Yu, Kai-Hooi Khoo, Kazuko Kitayama1, Tomoya O. Akama1, Kazuhiro Sugihara, Kyoko Kojima-Aikawa, Peter H. Seeberger, Minoru Fukuda, Atsushi Suzuki, Daisuke Aoki, and Michiko N. Fukuda.  Identification of mono- and di-sulfated N-acetyl-lactosaminyl oligosaccharide structures as epitopes specifically recognized by humanized monoclonal antibody HMOCC-1 raised against ovarian cancer.J. Biol. Chem.2012, 287, 6592-6602.

23.     Ping Wang, Xuechen Li, Jianglong Zhu, Jin Chen, Yu Yuan, Xiangyang Wu, Samuel J. Danishefsky. Encouraging Progress in the Ѡ-Aspartylation of Complex Oligosaccharides as a General Route to β-N-Linked Glycopolypeptides. J. Am. Chem. Soc. 2011. 133, 1597-1602.

24.     Ping Wang and Samuel J. Danishefsky. A Promising General Solution to the Problem of Ligating Peptides and Glycopeptides. J. Am. Chem. Soc. 2010. 132, 17045-17051.

25.     Xiangyang Wu, Jennifer L. Stockdill, Ping Wang and Samuel J. Danishefsky. Total Synthesis of Cyclosporine: Access to N-Methylated Peptides via Isonitrile Coupling Reactions. J. Am. Chem. Soc. 2010. 132, 4098-4100. (Highlighted by C&EN NEWS)

26.     Jin Chen, Ping Wang, Jianglong Zhu, Qian Wan and Samuel, J. Danishefsky. A Program for Ligation at Threonine Sites: Application to the Controlled Total Synthesis of Glycopeptides. Tetrahedron, 2010, 66, 2277-2283. (Cover of the Journal) 

27.     Ping Wang, Jianglong Zhu, Yu Yuan and Samuel, J. Danishefsky.Total Synthesis of the 2, 6-Sialylated Immunoglobulin G Glycopeptide Fragment in Homogeneous Form. J. Am. Chem. Soc. 2009, 131, 16669-16671. 

28.     Heeseob Lee, Ping Wang (co-first author), Motohiro Kobayashi, Jun Nakayama, Peter H. Seeberger and Minoru Fukuda. Cholesterol a-glucosyltransferase unique to Helicobacter pylori sequentially acts on donor and acceptor substrates:  Implication for the mode of actions by therapeutic inhibitors. Glycobiology. 2008, Jul; 18(7):549-58. Epub 2008 May 5.

29.     Ping Wang, Heeseob Lee, Minoru Fukuda and Peter H. Seeberger. One-pot synthesis of a pentasaccharide with antibiotic activity against Helicobacter pylori. Chem. Commun., 2007, 1963-1965.

30.     Heeseob Lee, Motohiro Kobayashi, Ping Wang, Jun Nakayama, Peter H. Seeberger and Minoru Fukuda. Expression cloning of cholesterol alpha -glucosyltransferase, a unique enzyme that can be inhibited by natural antibiotic gastric mucin O-glycans, from Helicobacter pylori. Biochem. Biophys. Res. Commun. 2006 Nov 3; 349(4): 1235-41. Epub 2006 Sep 1.

31.     Ping Wang, Zhaojun Zhang and Biao Yu. Total synthesis of CRM646-A, B. J .Org. Chem. 2005, 70(22), 8884-8889.

32.     Biao Yu and Ping Wang. Efficient synthesis of the Hexasaccharide Fragment of Landomycin A: Using Phenyl 2,3-O-Thionocarbonyl-1-thioglycosides as 2-Deoxy-β-glycosides Precursors. Org. Lett. 2002, 4, 1919-1922.

Patent

33.     Jeffrey V. Ravetch, Andrew Pincetic, Ping Wang, Samuel J. Danishefsky,Human DC-SIGN binding peptides derived from IgG1 Fc fragment. PCT Int. Appl. 2013, WO 2013095973 A1 20130627.

34.     Samuel J. Danishefsky, Ping Wang, Suwei Dong, Malcolm A. Moore, Jaehung Shieh, John A. Brailsford,. Homogenous and fully glycosylated human erythropoietin. PCT Int. Appl. (2013), WO 2013166053 A2 20131107.