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【24th.Oct.】Mechanical Engineering of Protein-based Biomaterials: from single molecule features to macroscopic trait ,

2018-10-23


题目:Mechanical Engineering of Protein-based Biomaterials: from single molecule features to macroscopic trait 
报告人:Prof. Hongbin Li, University of British Columbia
时间:2018年10月24日(周三),上午9:30
地点:化学A楼518会议室
邀请人:周永丰教授


Curriculum Vitae
HONGBIN LI, Ph. D. Professor, Department of Chemistry, University of British Columbia, Vancouver, BC, V6T 1Z1, Tel: 604-822-9669,Fax: 604-822-2847, Email: Hongbin@chem.ubc.ca

Education
09/1993-12/1998 Ph. D., Polymer Chemistry and Physics, Jilin University, P. R. China ,(Advisors: Profs. Jiacong Shen, Xi Zhang and Hermann Gaub)
09/1996 –09/1997 Joint training Ph.D. student, University of Munich, Germany, (Advisor: Prof. Hermann Gaub)
09/1989-07/1993 B. S., Polymer Engineering; Minor: Technical Economy and Management, Tianjin, University, P. R. China

Professional Experience
07/2013-present Professor, Department of Chemistry, University of British Columbia, Canada
10/2004-09/2014 Canada Research Chair (Tier II) in Molecular Nanoscience and Protein Engineering, Department of Chemistry, University of British Columbia, Canada
07/2009-06/2013 Associate Professor with tenure, Department of Chemistry, University of British, Columbia, Canada
08/2004-06/2009 Assistant Professor, Department of Chemistry, University of British Columbia, Canada
08/2002-08/2004 Associate Research Scientist, Columbia University, New York, NY, USA.
01/1999-08/2002 Research Fellow, Mayo Medical Center, Rochester, MN, USA, (Mentor: Prof. Julio Fernandez)

Honors and Awards
2017 Plenary Speaker, the 15th Pacific Polymer Congress
2016 Applied Chemistry Lectureship, Changchun Institute of Applied Chemistry
2012 Changjiang Scholar Distinguished Professor, Jilin University
2011 JILA Distinguished Visiting Fellowship
2011 Alexander von Humboldt Foundation Research Fellowship
2011 Charles A. McDowell Award for Excellence in Research
2010-2013 NSERC Discovery Accelerator Supplement Award
2006-2012 Career Investigator Award, Michael Smith Foundation for Health Research
2004-2014 Canada Research Chair (Tier II) in Molecular Nanoscience and Protein Engineering

Research Interests
Protein mechanics and engineering at the single molecule level, Protein-based biomaterials
Protein folding and unfolding dynamics


Selected Publications (since 2010)
1. Li, H. and Zheng, P. Curr. Opin Chem. Biol., 43, 58-67 (2018).
2. Lei, H., Guo, Y., Hu, X., Hu, C., Hu, X. and Li, H. B. J. Am. Chem. Soc. 139, 1358 (2017).
3. Lei, H., He, C., Hu, C., Li, J., Hu, X., Hu, X. and Li, H. Angew. Chem. Int. Ed., 56, 6117 (2017).
4. Lyu, S., Fang, J., Duan, T., Fu, L., Liu, J. and Li, H. Chem. Commun., 53, 13375 (2017).
5. Gao, X., Lyu, S. and Li, H. Biomacromolecules, 18, 3726-3732 (2017).
6. Gao, X., Fang, J., Xue, B., Fu, L. and Li, H. Biomacromolecules, 17, 2812−2819 (2016).
7. Zheng, P., Arantes, G. M., Field, M. J. and Li, H. B. Nature Commun., 6, 7569 (2015).
8. He, C., Hu, C., Hu, X., Hu, X., Xiao, A., Perkins, T.T. and Li, H. B. Angew. Chem. Intnl. Ed., 54, 9921 (2015).
9. Zheng, P., Wang, Y. and Li, H. Angew. Chem. Int. Ed. 53, 14060-14063 (2014).
10. Kong, N., Peng, Q. and Li, H., Adv. Funct. Mater. 24, 7310–7317 (2014).
11. He, C., Lamour, G., Xiao, A., Gsponer, J., Li, H. J. Am. Chem. Soc. 136, 11946−11955 (2014).
12. Fang, J., Mehlich, A., Koga, N., Huang, J., Koga, R., Gao, X., Hu, C., Jin, C., Rief, M., Kast, J., Baker, D., Li, H. Nature Commun., 4, 2974 (2013).
13. Zoldak, G. ; Stigler, J. ; Pelz, B. ; Li, H. ; Rief, M. Proc. Natl. Acad. Sci. USA., 110, 18156- 18161 (2013).
14. Zheng, P., Takayama, S.J., Mauk, A.G. and Li, H. B. J. Am. Chem. Soc., 134, 4124-4131(2012).
15. Zheng, P. and Li, H., J. Am. Chem. Soc. 133, 6791-6798 (2011).
16. Aioanei, D., Lv, S., Tessari, I., Rampioni, A. Bubacco, L., Li, H. Samori, B. and Brucale, M., Angew. Chem. Int. Ed. Engl. 50, 4394-4397 (2011).
17. Lv, S., Dudek, D.M., Cao, Y., Balamurali, M.M., Gosline, J. & Li, H. Nature, 465, 69-73 (2010)
18. Li, H. and Cao, Y., Acc. Chem. Res. 43, 1331-1341 (2010).



Mechanical Engineering of Protein-based Biomaterials: from single
molecule features to macroscopic traits
Hongbin Li
Department of Chemistry, University of British Columbia, Vancouver, BC V6T 1Z1, Canada
Email: Hongbin@chem.ubc.ca


Elastomeric proteins function as molecular springs in their biological settings to establish elastic connections, and provide mechanical strength, elasticity and extensibility. 



To fulfill their biological functions, elastomeric proteins have evolved to assume different structures, from simple random coil-like structure to more sophisticated beads-on-a-string conformation, and exhibit distinct mechanical properties. 


The development of single molecule force spectroscopy techniques has made it possible to directly probe the mechanical properties of such elastomeric proteins at the single molecule level and allowed to understand molecular design principles of these complex protein polymers. 


This knowledge has enabled us to engineer novel elastomeric proteins to achieve tailored and well-defined nanomechanical properties. 


Going a step further, we have started to employ these novel elastomeric proteins as building blocks to construct protein-based biomaterials,which in turn provide an ideal system to understand how single molecule anomechanical features are translated into biomechanical properties of macroscopic materials. 


These studies will pave the way to utilizing proteins as building blocks to engineer new generations of protein-based biomaterials for diverse applications in biomedical engineering as well as material sciences.





 


Reference
1. Lv, S., Dudek, D.M., Cao, Y., Balamurali, M.M., Gosline, J. & Li, H. Nature, 465, 69-73 (2010)
2. Li, H. and Cao, Y., Acc. Chem. Res. 43, 1331-1341 (2010).
3. Fang, J., Mehlich, A., Koga, N., Huang, J., Koga, R., Gao, X., Hu, C., Jin, C., Rief, M., Kast, J.,
Baker, D., Li, H. Nature Commun., 4, 2974 (2013).
4. Kong, N., Peng, Q. and Li, H., Adv. Funct. Mater. 24, 7310–7317 (2014).
5. Gao, X., Fang, J., Xue, B., Fu, L. and Li, H. Biomacromolecules, 17, 2812−2819 (2016).




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