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【20th.June】Precision Polymer Architectures and Conjugates to Enable Molecularly-Targeted and Cell-based Therapies

2017-06-20


TOPIC: Precision Polymer Architectures and Conjugates to Enable Molecularly-Targeted and Cell-based Therapies
SPEAKER: Prof.Craig L. Duvall, Vanderbilt University
TIME:June 20 (Tuesday)10:00am
LOCATION: Room 410, Chemistry Building B (化学B楼410会议室)
INVITER:A.Prof. Chuan Zhang  (张川特别研究员)


Seminar Abstract: The Duvall Advanced Therapeutics Laboratory in the Department of Biomedical Engineering at Vanderbilt University (Nashville, Tennessee, USA) specializes in design and application of smart polymer-based technologies for: (1) intracellular delivery of biological drugs such as peptides and nucleic acids, (2) proximity-activated targeting of drugs to sites of inflammation and matrix remodeling, and (3) long-term, “on-demand” drug release from localized depots. These delivery systems are designed to improve the therapeutic index of existing drugs and/or to serve as enabling technologies for manipulation of intracellular targets currently considered to be “undruggable”. To achieve optimal, finely-tuned therapeutic properties, polymers are utilized that respond to one or more environmental stimuli including pH, matrix metalloproteinases, reactive oxygen species, and temperature.  This talk will focus on the latest innovations from our group focused on development of molecularly-targeted. RNAi-based breast cancer therapies, improving longevity of autologous vascular bypass transplants, and development of cell and tissue-protective antioxidant biomaterials for tissue regenerative applications.  


Biography
Craig L. Duvall
Associate Professor and Director of Graduate Recruiting Department of Biomedical Engineering,Vanderbilt University, Nashville, TN, USA
Dr. Duvall completed his undergraduate studies at the University of Kentucky in 2001 and immediately started his doctoral studies in Biomedical Engineering at Georgia Tech and Emory University. His Ph.D. work was jointly directed by Dr. Robert Guldberg PhD, a mechanical/biomedical engineer from Georgia Tech, and Dr. W. Robert Taylor MD PhD, a cardiologist from Emory University. In 2007, Dr. Duvall joined the polymeric drug delivery technology labs of Dr. Patrick Stayton PhD and Dr. Allan Hoffman PhD in Bioengineering at the University of Washington for his NIH-funded postdoctoral fellowship. Based on the foundations built from these combined experiences, the Duvall Advanced Therapeutics Laboratory (ATL) was launched in the Vanderbilt Biomedical Engineering Department in 2010, and Dr. Duvall was promoted to Associate Professor in 2016. The Duvall Advanced Therapeutics Laboratory specializes in design and application of smart polymer-based technologies for: 
(1) intracellular delivery of biological drugs such as peptides and nucleic acids, 
(2) proximity-activated targeting of drugs to sites of inflammation and matrix remodeling, and 
(3) long-term, “on-demand” drug release from localized depots. These delivery systems are designed to improve the therapeutic index of existing drugs and/or to serve as enabling technologies for manipulation of intracellular targets currently considered to be “undruggable”. 


Dr. Duvall has won awards such as the PECASE, NSF CAREER Award, AHA Scientist Development Grant, Society for Biomaterials Young Investigator Award, and BMES Cellular and Molecular Bioengineering Young Innovator Award. His lab is funded by grants from NIH, DOD, NSF, AHA, and ADA.




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