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薛白


1、基本信息
姓名:薛白
职称:助理研究员
电话:021-34203400 
邮箱:bxue79@sjtu.edu.cn
通讯地址:上海市闵行区东川路800号上海交通大学系统生物医学研究院D406

2、教育经历
1997-2001:南京大学生物科学与技术系,学士
2001-2004:南京大学生物科学与技术系,硕士
2005-2010:美国纽约州立大学布法罗分校生物科学系,博士

3、工作经历
2010-2012:美国临床药效学研究所,研究助理
2013-2016:复旦大学生命科学学院遗传工程国家重点实验室,博士后
2017-至今:上海交通大学化学化工学院,助理研究员

4、研究方向
1)糖尿病、癌症等疾病发病、进展及其后果的分子生物学机制研究,疾病模型的构建以及相关药物研发。
2)药物代谢动力学/药效学研究及其相关模型的建立和应用。
3)系统生物学、生物信息学和转化生物学的研究。

5、科研项目
参于国家重大科技专项重大新药创制课题。

6、代表性论文 
1. Shi L, Xu L, Wu C, Xue B, Jin X, Yang J, Zhu X. “Celecoxib-Induced Self-Assembly of Smart Albumin-Doxorubicin Conjugate for Enhanced Cancer Therapy”. ACS Appl Mater Interfaces. 2018 Mar 14; 10(10):8555-8565.
2. Xu L, Yang J, Xue B, Zhang C, Shi L, Wu C, Su Y, Jin X, Liu Y, Zhu X. “Molecular insights for the biological interactions between polyethylene glycol and cells”. Biomaterials. 2017 Dec; 147:1-13.
3. Mou Q, Ma Y, Pan G, Xue B, Yan D, Zhang C, Zhu X. “DNA Trojan Horses: Self-Assembled Floxuridine-Containing DNA Polyhedra for Cancer Therapy”. Angew Chem Int Ed Engl. 2017 Oct 2; 56(41):12528-12532.
4. Guo D, Xu S, Wang N, Jiang H, Huang Y, Jin X, Xue B, Zhang C, Zhu X. “Prodrug-embedded angiogenic vessel-targeting nanoparticle: A positive feedback amplifier in hypoxia-induced chemo-photo therapy”. Biomaterials. 2017 Nov; 144:188-198.
5. Xue B, Nie J, Wang X, DuBois DC, Jusko WJ, Almon RR. “Effects of High Fat Feeding on Adipose Tissue Gene Expression in Diabetic Goto-Kakizaki Rats”. Gene Regul Syst Bio. 2015 Aug 10; 9:15-26.
6. Nie J, DuBois DC, Xue B, Jusko WJ, Almon RR. “Effects of High-Fat Feeding on Skeletal Muscle Gene Expression in Diabetic Goto-Kakizaki Rats”. Gene Regul Syst Bio. 2017 May 29; 11
7. Xue B, Zhang C`s\vl VE`s\vl V Lu M, Li G, Cao Z, Huang Q. “A Novel Controlled-Release System for Antibacterial Enzyme Delivery Using Hydroxyapatite/Chitosan Composite Bone Cement”. PLoS One. 2014 Dec 2; 9(12):e113797.
8. Rubino CM, Xue B, Bhavnani SM, Prince WT, Ivezic-Schoenfeld Z, Wicha WW, Ambrose PG. “Population Pharmacokinetic Analyses for BC-3781 Using Phase 2 Data from Patients with Acute Bacterial Skin and Skin Structure Infections”. Antimicrob Agents Chemother. Epub 2014 Oct 27.
9. Bai Xue, Siddharth Sukumaran, Jing Nie, William Jusko, Debra DuBois, Richard Almon. “Adipose Tissue Deficiency and Chronic Inflammation in Diabetic Goto-Kakizaki Rats”. PLoS One. 2011 Feb 25; 6(2):e17386.
10. Richard R. Almon, Debra C. DuBois, Siddharth Sukumaran, Xi Wang, Bai Xue, Jing Nie, William J. Jusko. “Effects of High Fat Feeding on Liver Gene Expression in Diabetic Goto-Kakizaki Rats”. Gene Regul Syst Bio. 2012; 6:151-68. Epub 2012 Nov 28.
11. Jing Nie, Bai Xue, Siddharth Sukumaran, William J. Jusko, Debra C. DuBois, Richard R. Almon. “Differential Muscle Gene Expression as a Function of Disease Progression in Goto-Kakizaki Diabetic Rats”. Mol Cell Endocrinol. 2011 Feb 26.
12. Siddharth Sukumaran, Bai Xue, William J. Jusko, Debra C. Dubois, Richard R. Almon. “Circadian Variations in Gene Expression in Rat Abdominal Adipose Tissue and Relationship to Physiology”. Physiol Genomics. 2010 Oct; 42A(2):141-52. Epub 2010 Aug 3.
13. Almon RR, DuBois DC, Lai W, Xue B, Nie J, Jusko WJ. “Gene Expression Analysis of Hepatic Roles in Cause and Development of Diabetes in Goto-Kakizaki Rats”. J Endocrinol. 2009 Mar; 200(3):331-46.
14. C Landersdorfer, S Robertson, S Bihorel, B Xue, W Gao, C Keller, J Nie, R Almon, D DuBois, W Jusko. “Mechanistic Modeling of Genetic and Nutritional Influences on Growth in Normal Wistar (CON) and Type 2 Diabetic Goto-Kakizaki Rats (GK)”. The AAPS Journal. 2007; 9(S1): http://www.aapsj.org/.


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