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张书宇

 

 

1、基本信息:


姓名:张书宇

职称:特别研究员

电话:021-54747808

邮箱:zhangsy16@sjtu.edu.cn

主页:scce.sjtu.edu.cn

通讯地址:上海市东川路800号上海交通大学化学化工学院B329




2、教育经历

1998-2002:兰州大学化学化工学院,学士

2005-2010:兰州大学化学化工学院,博士(导师:涂永强院士)


3、工作经历

2002-2010:兰州大学化学化工学院,功能有机分子化学国家重点实验室

2010-2011:美国芝加哥大学(Chicago University)化学系,博士后(导师:何川教授)

2011-2014:美国宾夕法尼亚州立大学(Penn State University)化学系,博士后(导师:陈弓教授)

2015- :       上海交通大学化学化工学院,特别研究员


4、研究方向

1 以非活泼sp3C-H键活化反应为核心的天然产物及活性药物分子的全合成;

2 涉及多种化学键构建的非活泼sp3C-H键活化新反应及不对称反应的研究;

3 与化学生物学相结合的化学反应方法及仿生合成研究。


5、教育教学

本科生《Organometallic Chemistry

研究生《高等金属有机化学》


6、荣誉及奖励


2015 教育部自然科学一等奖(R5)

2016 上海市曙光计划

2016 国家自然科学二等奖(R5)




7、近期发表论文


1) Computational and Experimental Studies on Copper-Catalyzed Selective Cascade C-H/N-H Annulation of Electron-Deficient Acrylamide with Arynes

C. Chen, Y. Hao, T.-Y. Zhang, J.-L. Pan, J. Ding, H.-Y. Xiang, M. Wang, T.-M. Ding, A. Duan,* S.-Y. Zhang*

Chem. Commun. 2019, 55, 755. (Inside front cover designed by Chen Mao, freshman at SJTU)

2) Rhodium(III)-Catalyzed Redox-Neutral Cascade [3 + 2] Annulation of N‑Phenoxyacetamides with Propiolates via CH Functionalization/Isomerization/Lactonization

J.-L. Pan, P. Xie, C. Chen, Y. Hao, C. Liu, H.-Y. Bai, J. Ding, L.-R. Wang, Y. Xia,* and S.-Y. Zhang*

Org. Lett. 2018, 20, 7131.

3) A Facile Approach to Oximes and Ethers by aTandem NO+-Initiated Semipinacol Rearrangement and H-Elimination

J.-W. Dong, T.-M. Ding, S.-Y. Zhang,* Z.-M. Chen,* and Y.-Q. Tu*

Angew. Chem. Int. Ed. 2018, 57, 13192.

4) Transition Metal-Controlled Direct Regioselective Intermolecular Amidation of CH Bonds with Azodicarboxylates: Scope, Mechanistic Studies, and Applications

H.-Y. Bai, X. Fu, J.-L. Pan, H.-Q. Ma, Z.-M. Chen, T.-M. Ding,* and S.-Y. Zhang*

Adv. Synth. Catal. 2018, 360, 4205. (Full Paper)

5) Experimental and computational studies on H2O-promoted, Rh-catalyzed transient-ligand free ortho-C(sp2)–H amidation of benzaldehydes with dioxazolones

J. Ding, W. Jiang, H.-Y. Bai, T.-M. Ding, D. Gao, X. Bao* and S.-Y. Zhang *

Chem. Commun. 2018, 54, 8889.

6) Metal-Controlled, Regioselective, Direct Intermolecular α- or γ‑Amination with Azodicarboxylates

X. Fu, H.-Y. Bai, G.-D. Zhu, Y. Huang,*, and S.-Y. Zhang*

Org. Lett. 2018, 20, 3469.

7) Copper-Mediated Cascade CH/NH Annulation of Indolocarboxamides with Arynes: Construction of Tetracyclic Indoloquinoline Alkaloids

T.-Y. Zhang, C. Liu, C. Chen, J.-X. Liu, H.-Y. Xiang, W. Jiang, T.-M. Ding, S.-Y. Zhang*

Org. Lett. 2018, 20, 220.

8) Mechanistic insights into staphylopine-mediated metal acquisition

L. Song, Y. Zhang, W. Chen, T. Gu, S.-Y. Zhang, and Q. Ji*

PNAS, 2018, 115, 3942.

9) Recent progress in the isolation, bioactivity, biosynthesis, and total synthesis of natural spiroketals

F.-M. Zhang, S.-Y. Zhang and Y.-Q. Tu*

Nat. Prod. Rep. 2018, 35, 75.

10) Stereoselective Synthesis of Z Vinylsilanes via Palladium-Catalyzed Direct Intermolecular Silylation of C(sp2)H Bonds

J.-L. Pan, C. Chen, Z.-G. Ma, J. Zhou, L.-R. Wang, S.-Y. Zhang*

Org. Lett. 2017, 19, 5216.

11) Copper-Catalyzed Selective ortho-CH/NH Annulation of Benzamides with Arynes: Synthesis of Phenanthridinone Alkaloids

T.-Y. Zhang, J.-B. Lin, Q.-Z. Li, J.-C. Kang, J.-L. Pan, S.-H. Hou, C. Chen, S.-Y. Zhang*

Org. Lett. 2017, 19, 1764.

12) Palladium-Catalyzed Direct Intermolecular Amination of Unactivated Methylene C(sp3)H Bonds with Azodiformates via Bidentate-Chelation Assistance

H.-Y. Bai, Z.-G. Ma, M. Yi, J.-B. Lin, S.-Y. Zhang*

ACS Catal. 2017, 7, 2042.

13) Palladium-catalyzed direct intermolecular silylation of remote unactivated C(sp3)-H bonds

J.-L. Pan, Q.-Z. Li, T.-Y. Zhang, S.-H. Hou, J.-C. Kang, S.-Y. Zhang*

Chem. Commun. 2016, 52 , 13151.


*本科在读及毕设同学

感谢国家自然科学基金、上海市科委、上海市教委、上海交通大学经费支持!



8、代表性论文


1) S.-Y. Zhang, Q. Li, G. He, W. A. Nack, and G. Chen*

Pd-Catalyzed Monoselective ortho-C–H Alkylation of N-Quinolyl Benzamides: Evidence for Stereoretentive Coupling of Secondary Alkyl Iodides

J. Am. Chem. Soc. 2015, 137, 531. (ESI Highly Cited Paper, ESI Hot Paper)

2) S.-Y. Zhang, Q. Li, G. He, W. A. Nack, and G. Chen*

Stereoselective Synthesis of β-Alkylatedα-Amino Acids via Palladium-Catalyzed Alkylation of Unactivated Methylene C(sp3)-H Bonds with Primary Alkyl Halides

J. Am. Chem. Soc. 2013, 135, 12135. (ESI Highly Cited Paper)

3) S.-Y. Zhang, G. He, W. A. Nack, Y. Zhao, Q. Li, and G. Chen*

Palladium-Catalyzed Picolinamide-Directed Alkylation of Unactivated C(sp3)H Bonds with Alkyl Iodides

J. Am. Chem. Soc. 2013,135, 2124. (ESI Highly Cited Paper)

4) S.-Y. Zhang, G. He, Y. Zhao, K. Wright, W. A. Nack, and G. Chen*

Efficient alkyl ether synthesis via palladium-catalyzed, picolinamide-directed alkoxylation of unactivated C(sp3)-H and C(sp2)-H bonds at remote positions

J. Am. Chem. Soc. 2012, 134, 7313. (ESI Highly Cited Paper)

5) S.-Y. Zhang, F.-M. Zhang and Y.-Q. Tu*

Direct Sp3α-C-H activation and functionalization of alcohol and ether

Chem. Soc. Rev. 2011, 40, 1937. (ESI Highly Cited Paper)

6) S.-Y. Zhang, Y.-Q. Tu,* C.-A. Fan, F.-M. Zhang, and L. Shi

Iron-Catalyzed C(sp3)-C(sp3) Bond Formationvia sp3C-H Functionalization: A Cross-Coupling Reaction of Alcohols with Alkenes

Angew. Chem. Int. Ed. 2009, 48, 8761. (Angew Hot Paper, Most accessed)




9. 实验室动态


1)课题组2020年研究生招生已满。

2白贺元刘畅同学获得2018年度研究生奖学金。

32017级本科生何俊佳王训辉同学的大创项目IPP18080 正式立项。

4)本组第一位硕士研究生张婷玉同学(2015级,2.5年制)顺利按期毕业,张婷玉同学硕士研究生期间系统发展了铜催化的C-H/N-H串联环化反应,以第一作者在Org .Lett.上发表论文2篇,专利2项,获评2018上海市优秀毕业生称号。

本组目前有博士后职位,申请者请将个人简历及研究简介发到zhangsy16@sjtu.edu.cn, 近期的研究兴趣主要围绕有机化学方法学及全合成,以及与化学生物学相关的一系列反应研究,欢迎对有机化学、药物化学、以及化学生物学有兴趣的同学报考本组的硕士和博士研究生。 课题组对本科生开放并承担大创项目,接收爱好化学的本科同学加入课题组学习。

 

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上海交通大学化学化工学院

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地址:上海市东川路800号 200240

电话:021-54742571

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