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Changkun Li

Associate Professor

Department of:   Chemistry

Phone:  

Email:  chkli@sjtu.edu.cn


Education

2000-2004       B.S. Chemistry, Peking University, P. R. China.
2004-2010       Ph.D. Organic Chemistry, Peking University, P. R. China.
                           with Prof. Jianbo Wang and Yan Zhang

Working Experience

2016.03-now         Associate Professor, group leader
                              School of Chemistry and Chemical Engineering                     
                              Shanghai Jiaotong University, P. R. China

2012.10-2016.02   PostDoc, Humboldt Fellow
                              Institut für Organische Chemie,
                              Albert-Ludwigs-Universität Freiburg, Germany
                              Supervisor: Professor Bernhard Breit

2010.07-2012.10   PostDoc, JSPS Fellow
                              Department of Synthetic Chemistry and Biological  
                              Chemistry, Graduate School of Engineering,
                              Kyoto University, Japan
                              Supervisor: Professor Masahiro Murakami


Awards: 

2020 Thieme Chemistry Journal Award

2013 Humboldt Fellowship

2011 JSPS Fellowship

 


Fields of Interests

Organometalic Chemistry, Asymmetric Catalysis and Organic Synthesis
 
Publications

(14 Rh-Catalyzed Chemodivergent Regio- and Enantioselective Allylic Alkylation of Indoles
Minghe Sun, Min Liu, Changkun Li*

Chem. Eur. J. doi.org/10.1002/chem.202004613


(13Enantioselective Synthesis of 3-Allylindolizines via Sequential Rh-Catalyzed Asymmetric Allylation and Tschitschibabin Reaction
Ke Li, Changkun Li*

Org. Lett. 202022doi.org/10.1021/acs.orglett.0c03383




(12) Regio- and Enantioselective Allylic Alkylation of Terminal Alkynes by Synergistic Rh/Cu Catalysis

Wen-Yu Huang, Chun-Hua Lu, Samir Ghorai, Bing Li, Changkun Li*

J. Am. Chem. Soc. 2020, 142, 15276-15281.  


(11Desymmetrization construction of chiral lactones by synergistic Cu(II) complex and organic base

Murad Ali, Changkun Li*

Tetrahedron Lett. 2020, https://doi.org/10.1016/j.tetlet.2020.152106

 


(10) Cobalt/Bisoxazolinephosphine-Catalyzed Asymmetric Alkynylation of Isatins

Jia-Feng Chen, Changkun Li*

Org. Lett. 2020, 22, 12, 4686–4691



(9) Rh(I)-Catalyzed Regio- and Enantioselective Allylic Alkylation of Meldrum's Acid 

Min Liu, Haiying Zhao,* Changkun Li.*

Chin. Chem. Lett. 2020, 31, doi.org/10.1016/j.cclet.2020.04.009.


(8) Cobalt-Catalyzed Regio- and Enantioselective Allylic Alkylation of Malononitriles

Samir Ghorai, Sajid Ur Rehman, Wen-Bin Xu, Wenyu Huang, Changkun Li.*

Org. Lett. 2020, 22, 3519-3523.

 


(7) Rh(I)/Bisoxazolinephosphine-Catalyzed Regio- and Enantioselective Allylic Substitutions

Wen-Bin Xu, Samir Ghorai, Wenyu Huang, Changkun Li.*

ACS. Catal. 2020, 10, 4491-4496.

 


(6) Pd-Catalyzed Enantioselective Synthesis of 2-Methyl-3-methyleneindoline. 

Chun-Hua Lu, Sima, Darvishi, Vahid, Khakyzadeh, Changkun Li.*

Chin. Chem. Lett. 2020, 31, doi.org/10.1016/j.cclet.2020.02.056. 


(5) Cobalt-Catalyzed gem-Cross-Dimerization of Terminal Alkynes.

Jia-Feng Chen, Changkun Li.*

ACS. Catal. 2020, 10, 3881-3889. 


(4) Cobalt-Catalyzed Regio- and Enantioselective Allylic Amination. 

Samir Ghorai, Sahadev Shrihari Chirke, Wen-Bin Xu, Jia-Feng Chen, Changkun Li.*

J. Am. Chem. Soc. 2019, 141, 11430−11434.

 


(3) Construction of Vicinal Quaternary Carbon Centers via Cobalt-Catalyzed Asymmetric Reverse Prenylation.

Minghe Sun#, Jia-Feng Chen#, Shufeng Chen, Changkun Li.*

Org. Lett. 2019, 21, 1278-1281. (#, equal contribution)


(2) Enol Ester Synthesis via Cobalt-Catalyzed Regio- and Stereoselective Addition of Carboxylic Acids to Alkynes.

Jia-Feng Chen, Changkun Li.*

Org. Lett. 2018, 20, 6719-6724.


 


(1) Rh(I)-Catalyzed Carbonylative [3+1] Constrcution of Cyclobutenones

via C-C s-Bond Activation of Cyclopropenes.

Wen-Bin Xu, Changkun Li,* and Jianbo Wang

Chem. Eur. J. 2018, 24, 15786-15790.

 


Before 2016

(1) Rhodium-Catalyzed Chemo-, Regio-, and Enantioselective Addition of 2-Pyridones to Terminal Allenes

Changkun Li, Matthias Kähny and Bernhard Breit* Angew. Chem., Int. Ed. 2014, 53, 13780-13784.
(2) Rhodium-Catalyzed Chemo- and Regioselective Decarboxylative Addition of β-Ketoacids to Allenes: Efficient Construction of Tertiary and Quaternary Carbon Centers
Changkun Li, and Bernhard Breit* J. Am. Chem. Soc. 2014, 136, 862-865.
(3) Pyridine-Directed Palladium-Catalyzed Phosphonation of C(sp2)-H Bonds
Changkun Li, Takaaki Yano, Naoki Ishida, and Masahiro Murakami* Angew. Chem., Int. Ed. 2013, 52, 9801-9804.
(4) Gold(I)-Catalyzed Cycloisomerization of Enynes Containing Cyclopropenes
Changkun Li, Yi Zeng, Hang Zhang, Jiajie Feng, Yan Zhang, Jianbo Wang* Angew. Chem., Int. Ed. 2010, 49, 6413-6417.
 
Postdoctoral Positions available

Candidates with  organic synthesis, organometallic chemistry or inorgnic chemistry background are welcome to apply.

If you are interested, please send your CV to chkli@sjtu.edu.cn at any time.