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Associate Professor

Department of:   Chemistry

Phone:   (+1)-814-954-2758

Email:  shuyu16@gmail.com

Email: zhangsy16@sjtu.edu.cn
800 Dongchuan Road, B329 Chemistry Building, Shanghai, 200240, P.R.China



1998-2002        B.S. Chemistry, Lanzhou University, P. R. China.
2005-2010        Ph.D. Organic Chemistry, Lanzhou University, P. R. China.


Working Experience
2002-2010        Lanzhou University, State Key Lab. of Applied Org. Chem.
2010-2011        Postdoctor, Department of Chemistry, Chicago University, USA.
2011-2014        Postdoctor, Department of Chemistry, Penn State University, USA.
2015-                Associate Professor, School of Chemistry and Chemical Engineering,
                         Shanghai Jiao Tong University, P. R. China


Fields of Interests

Our current research program is interested in synthetic methodology, synthesis of natural products, medicinal chemistry, and Chemical biology.


Recent Publications


1) Highly atroposelective synthesis of nonbiaryl naphthalene-1,2-diamine N-C atropisomers through direct enantioselective C-H amination

H.-Y. Bai, F.-X. Tan, T.-Q. Liu, G.-D. Zhu, J.-M. Tian, T.-M. Ding, Z.-M. Chen, S.-Y. Zhang*

Nature Commun. 201910. 3063. (Editors' Highlights)

2) Electrochemical Halogenation/Semi-pinacol Rearrangement of Allylic Alcohols Using Inorganic Halide Salt: An Eco-friendly Route to Synthesis of β-halocarbonyls

C. Chen, J.-C. Kang, C. Mao, J.-W. Dong, Y.-Y. Xie, T.-M. Ding, Y.-Q. Tu, Z.-M. Chen* and S.-Y. Zhang*

Green Chem. 201921, 4014. (Inside front cover)

3) Asymmetric N-hydroxyalkylaltion of Indoles with Ethyl Glyoxalates Catalyzed by a Chiral Phosphoric Acid: Highly Enantioselective Synthesis of Chiral N,O-aminal Indole Derivatives

L. Wang, J. Zhou, T.-M. Ding, Z.-Q. Yan, G.-D. Zhu,* and S.-Y. Zhang*

Org. Lett. 201921, 2795.

4) Electrochemical Semipinacol Rearrangements of Allylic Alcohols: Construction of All-Carbon Quaternary Stereocenters

J.-C. Kang, Y.-Q. Tu, J.-W. Dong, C. Chen, J. Zhou, T.-M. Ding, J.-T. Zai, Z.-M. Chen,* and S.-Y. Zhang*

Org. Lett. 201921, 2536. (Most downloaded)

5) Dual Directing Groups-Assisted Redox-Neutral Annulation and Ring-Opening of N-Aryloxyacetamides with 1-Alkynylcyclobutanols via Rhodium(III)-Catalyzed C–H/C–C Activations

J.-L. Pan, C. Liu, C. Chen, T.-Q. Liu, M. Wang, Z. Sun* and S.-Y. Zhang*

Org. Lett. 201921, 2823.

6) Asymmetric Organocatalytic Synthesis of 2,3-Allenamides from Hydrogen Bond-Stabilized Enynamides

Z.-G. Ma, J.-L. Wei, J.-B. Lin, G.-J. Wang, J. Zhou, K. Chen, C.-A. Fan* and S.-Y. Zhang* 

Org. Lett. 201921, 2468.

7) Computational and Experimental Studies on Copper-Catalyzed Selective Cascade C-H/N-H Annulation of Electron-Deficient Acrylamide with Arynes

C. Chen, Y. Hao, T.-Y. Zhang, J.-L. Pan, J. Ding, H.-Y. Xiang, M. Wang, T.-M. Ding, A. Duan,* S.-Y. Zhang*

Chem. Commun. 201955, 755. (Inside front cover designed by Chen Mao, freshman at SJTU)


1) Rhodium(III)-Catalyzed Redox-Neutral Cascade [3 + 2] Annulation of N‑Phenoxyacetamides with Propiolates via CH Functionalization/Isomerization/Lactonization

J.-L. Pan, P. Xie, C. Chen, Y. Hao, C. Liu, H.-Y. Bai, J. Ding, L.-R. Wang, Y. Xia,* and S.-Y. Zhang*

Org. Lett. 201820, 7131.

2) A Facile Approach to Oximes and Ethers by aTandem NO+-Initiated Semipinacol Rearrangement and H-Elimination

J.-W. Dong, T.-M. Ding, S.-Y. Zhang,* Z.-M. Chen,* and Y.-Q. Tu*

Angew. Chem. Int. Ed. 201857, 13192.

3) Transition Metal-Controlled Direct Regioselective Intermolecular Amidation of CH Bonds with Azodicarboxylates: Scope, Mechanistic Studies, and Applications

H.-Y. Bai, X. Fu, J.-L. Pan, H.-Q. Ma, Z.-M. Chen, T.-M. Ding,* and S.-Y. Zhang*

Adv. Synth. Catal. 2018360, 4205. (Full Paper)

4) Experimental and computational studies on H2O-promoted, Rh-catalyzed transient-ligand free ortho-C(sp2)–H amidation of benzaldehydes with dioxazolones

J. Ding, W. Jiang, H.-Y. Bai, T.-M. Ding, D. Gao, X. Bao* and S.-Y. Zhang *

Chem. Commun. 201854, 8889.

5) Metal-Controlled, Regioselective, Direct Intermolecular α- or γ‑Amination with Azodicarboxylates

X. Fu, H.-Y. Bai, G.-D. Zhu, Y. Huang,* and S.-Y. Zhang*

Org. Lett. 201820, 3469.

6) Copper-Mediated Cascade CH/NH Annulation of Indolocarboxamides with Arynes: Construction of Tetracyclic Indoloquinoline Alkaloids

T.-Y. Zhang, C. Liu, C. Chen, J.-X. LiuH.-Y. XiangW. Jiang, T.-M. Ding, S.-Y. Zhang*

Org. Lett. 201820, 220.

7) Mechanistic insights into staphylopine-mediated metal acquisition

L. Song, Y. Zhang, W. Chen, T. Gu, S.-Y. Zhang, and Q. Ji*

PNAS, 2018115, 3942.

8) Recent progress in the isolation, bioactivity, biosynthesis, and total synthesis of natural spiroketals

F.-M. Zhang, S.-Y. Zhang and Y.-Q. Tu*

Nat. Prod. Rep. 201835, 75. 


1) Stereoselective Synthesis of Z Vinylsilanes via Palladium-Catalyzed Direct Intermolecular Silylation of C(sp2)H Bonds

J.-L. Pan, C. Chen, Z.-G. Ma, J. Zhou, L.-R. WangS.-Y. Zhang*

Org. Lett. 201719, 5216.

2) Copper-Catalyzed Selective ortho-CH/NH Annulation of Benzamides with Arynes: Synthesis of Phenanthridinone Alkaloids

T.-Y. Zhang, J.-B. Lin, Q.-Z. Li, J.-C. Kang, J.-L. Pan, S.-H. Hou, C. Chen, S.-Y. Zhang*

Org. Lett. 201719, 1764.

3) Palladium-Catalyzed Direct Intermolecular Amination of Unactivated Methylene C(sp3)H Bonds with Azodiformates via Bidentate-Chelation Assistance

H.-Y. Bai, Z.-G. Ma, M. Yi, J.-B. Lin, S.-Y. Zhang*

ACS Catal. 20177, 2042. 


1) Palladium-catalyzed direct intermolecular silylation of remote unactivated C(sp3)-H bonds

J.-L. Pan, Q.-Z. Li, T.-Y. Zhang, S.-H. Hou, J.-C. KangS.-Y. Zhang*

Chem. Commun. 201652 , 13151.

Selected Publications 

1) S.-Y. Zhang, Q. Li, G. He, W. A. Nack, and G. Chen*

Pd-Catalyzed Monoselective ortho-C–H Alkylation of N-Quinolyl Benzamides: Evidence for  Stereoretentive Coupling of Secondary Alkyl Iodides

J. Am. Chem. Soc. 2015, 137, 531. (ESI Highly Cited Paper, ESI Hot Paper)

2) S.-Y. Zhang, Q. Li, G. He, W. A. Nack, and G. Chen*

Stereoselective Synthesis ofβ-Alkylatedα-Amino Acids via Palladium-Catalyzed Alkylation of Unactivated Methylene C(sp3)-H Bonds with Primary Alkyl Halides

J. Am. Chem. Soc. 2013, 135, 12135. (ESI Highly Cited Paper)

3) S.-Y. Zhang,G. He, W. A. Nack, Y. Zhao, Q. Li, and G. Chen*

Palladium-Catalyzed Picolinamide-Directed Alkylation of Unactivated C(sp3)H Bonds with Alkyl Iodides

J. Am. Chem. Soc. 2013,135, 2124. (ESI Highly Cited Paper)

4) S.-Y. Zhang, G. He, Y. Zhao, K. Wright, W. A. Nack, and G. Chen*

Efficient alkyl ether synthesis via palladium-catalyzed, picolinamide-directed alkoxylation of unactivated C(sp3)-H and C(sp2)-H bonds at remote positions

J. Am. Chem. Soc. 2012, 134, 7313. (ESI Highly Cited Paper)

5) S.-Y. Zhang, F.-M. Zhang and Y.-Q. Tu*

Direct Sp3α-C-H activation and functionalization of alcohol and ether

Chem. Soc. Rev. 2011, 40, 1937. (ESI Highly Cited Paper)

6) S.-Y. Zhang, Y.-Q. Tu,* C.-A. Fan, F.-M. Zhang, and L. Shi

Iron-Catalyzed C(sp3)-C(sp3) Bond Formationvia sp3C-H Functionalization: A Cross-Coupling Reaction of Alcohols with Alkenes

Angew. Chem. Int. Ed. 2009, 48, 8761. (Angew Hot Paper, Most accessed)


Research Opportunities

We are always looking to recruit talented and committed scientists. If you are interested in working in our group, please feel free to contact me anytime.

Postdoctoral Positions

Postdoctoral position available at: (http://join.sjtu.edu.cn/ZPSpecialShow.aspx?id=510). Candidates must possess a PhD, less than 35 years old, and strong research skills and background in total synthesis, catalytic asymmetric, or organometallic chemistry.

Ph.D. Positions

PhD positions are available in our group two times each year, usually starting in April or September. For international students, see: http://isc.sjtu.edu.cn (Application periodDec. 1-Apr. 30). If you are interested in a PhD with our group, please contact me and send your CV and Statement to zhangsy16@sjtu.edu.cn anytime.